Protein Alignment GRIK5 and Ir84a

DIOPT Version :10

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 698
• Identity: 153/698 - (21%)
• Similarity: 272/698 - (38%)
• Gaps: 191/698 - (27%)

Human   243 ILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMS-------------WRENC-- 292
            |:.|....:|.::.|   ::|.|..:.|.       :|:||.::|             |:..|
  Fly    14 IILTAFLRVLQIESI---NTNFLELAAFE-------DFLRSEHLSHVLVVRGDDADGDWKIECHQ 68

Human   293 -------------------EASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSAN 338
                               |...:.|...:|.|:.::.||:|       |.|..||
  Fly    69 KLLANYRVQFYRPEMSANFEDLMFYGSPRTAVLVLNSEHVLV-------RRQVFGV--------- 117

Human   339 IWPHGTSLMNYLRMVEYDGLTGRVEFNS--------KGQRTNYTLRILEKSRQGHREIGVWYSNR 395
                 .|...|              ||:        .|:.:....:::::...|:| :|: .::.
  Fly   118 -----ASEAGY--------------FNNSLAWFILGSGRESLPVEQLIDQLLSGYR-MGI-DADI 161

Human   396 TLAM----NATTL--DINLSQTLANKTLVVTT--------------ILENPYVMRRPNF--QALS 438
            |:|:    ||:.|  |:......||..|::..              ..:|.:|:||.||  ..|.
  Fly   162 TVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLI 226

Human   439 GN----ERFEGFCVDM--------LRELAELLRFRYRL-RLVE-----------DGLYGAPEPNG 479
            |:    |:..|| .||        |::|..:.|..|:| :|||           ...:|....||
  Fly   227 GSTVLTEKPPGF-GDMEYLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLTDKWGELLDNG 290

Human   480 SWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFS 544
            ||:|::|::.:|: ||.||.......:|:..:.:|....|..|..|:| |..|......|.:|.|
  Fly   291 SWSGVMGQVTSRE-ADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFR-HPRRSHIKNIFFEPLS 353

Human   545 PAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFP-VGGFMQQG 608
            ..|| :.:||.:..|.:|.|.           |..|......:||:::.   :||. :..::|||
  Fly   354 NQVW-WCVLALVTGSTILLLF-----------HVRLERMLSNMENRFSF---VWFTMLETYLQQG 403

Human   609 --SEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD-----QTNIE 666
              :||. |..|||.:..:...|:.:::..|.|.:...|.       .|||..:.:     .:|:.
  Fly   404 PANEIF-RLFSTRLLISLSCIFSFMLMQFYGAFIVGSLL-------SESARSIVNLQALYDSNLA 460

Human   667 YGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAF----------L 721
            .|..:.......|.|:..|..:.::.....|.....:.|.::|..|::..|:||          |
  Fly   461 IGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIMSLQQGAERIIQGRFAFHTAIDRMYRLL 525

Human   722 LESTMNEYHRRLNCNLTQIGGLLDTKGYGIG--MPLGSPFRDEITLAILQLQENNRLEILKRKWW 784
            ||..|:|..   .|:|.::   :....|..|  ||.|||:|:.:..|:|..:....|:...:||.
  Fly   526 LELQMDEAE---FCDLQEV---MFNLPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWM 584

Human   785 -EGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI--W 829
             ....|...:..:|: :.:|:.......|...::.:..|.::|..  |
  Fly   585 VRRPDCSLFKTSQAE-VDLEHFAPALFALALAMVASALVFLLELFLHW 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	34/203 (17%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	107/431 (25%)
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	9/64 (14%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	23/74 (31%)
		Lig_chan	353..602	CDD:459656	64/278 (23%)