DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK5 and Ir84a

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_649720.2	Gene:	Ir84a / 40891	FlyBaseID:	FBgn0037501	Length:	644	Species:	Drosophila melanogaster

Alignment Length:	698	Identity:	153/698 - (21%)
Similarity:	272/698 - (38%)	Gaps:	191/698 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   243 ILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMS-------------WRENC-- 292
            |:.|....:|.::.|   ::|.|..:.|.       :|:||.::|             |:..|
  Fly    14 IILTAFLRVLQIESI---NTNFLELAAFE-------DFLRSEHLSHVLVVRGDDADGDWKIECHQ 68

Human   293 -------------------EASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSAN 338
                               |...:.|...:|.|:.::.||:|       |.|..||
  Fly    69 KLLANYRVQFYRPEMSANFEDLMFYGSPRTAVLVLNSEHVLV-------RRQVFGV--------- 117

Human   339 IWPHGTSLMNYLRMVEYDGLTGRVEFNS--------KGQRTNYTLRILEKSRQGHREIGVWYSNR 395
                 .|...|              ||:        .|:.:....:::::...|:| :|: .::.
  Fly   118 -----ASEAGY--------------FNNSLAWFILGSGRESLPVEQLIDQLLSGYR-MGI-DADI 161

Human   396 TLAM----NATTL--DINLSQTLANKTLVVTT--------------ILENPYVMRRPNF--QALS 438
            |:|:    ||:.|  |:......||..|::..              ..:|.:|:||.||  ..|.
  Fly   162 TVALRGPDNASMLFYDVYRISRQANTPLIIEKKGLWTHSGGYQKFGNFKNTWVIRRRNFLNVTLI 226

Human   439 GN----ERFEGFCVDM--------LRELAELLRFRYRL-RLVE-----------DGLYGAPEPNG 479
            |:    |:..|| .||        |::|..:.|..|:| :|||           ...:|....||
  Fly   227 GSTVLTEKPPGF-GDMEYLADDKQLQQLDPMQRKTYQLFQLVERMFNLSLAISLTDKWGELLDNG 290

Human   480 SWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFS 544
            ||:|::|::.:|: ||.||.......:|:..:.:|....|..|..|:| |..|......|.:|.|
  Fly   291 SWSGVMGQVTSRE-ADFAVCPIRFVLDRQPYVQYSAVLHTQNIHFLFR-HPRRSHIKNIFFEPLS 353

Human   545 PAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFP-VGGFMQQG 608
            ..|| :.:||.:..|.:|.|.           |..|......:||:::.   :||. :..::|||
  Fly   354 NQVW-WCVLALVTGSTILLLF-----------HVRLERMLSNMENRFSF---VWFTMLETYLQQG 403

Human   609 --SEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD-----QTNIE 666
              :||. |..|||.:..:...|:.:::..|.|.:...|.       .|||..:.:     .:|:.
  Fly   404 PANEIF-RLFSTRLLISLSCIFSFMLMQFYGAFIVGSLL-------SESARSIVNLQALYDSNLA 460

Human   667 YGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAF----------L 721
            .|..:.......|.|:..|..:.::.....|.....:.|.::|..|::..|:||          |
  Fly   461 IGMENISYNFPIFTNTSNQLVRDVYVKKICKSGEHNIMSLQQGAERIIQGRFAFHTAIDRMYRLL 525

Human   722 LESTMNEYHRRLNCNLTQIGGLLDTKGYGIG--MPLGSPFRDEITLAILQLQENNRLEILKRKWW 784
            ||..|:|..   .|:|.::   :....|..|  ||.|||:|:.:..|:|..:....|:...:||.
  Fly   526 LELQMDEAE---FCDLQEV---MFNLPYDSGSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWM 584

Human   785 -EGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI--W 829
             ....|...:..:|: :.:|:.......|...::.:..|.::|..  |
  Fly   585 VRRPDCSLFKTSQAE-VDLEHFAPALFALALAMVASALVFLLELFLHW 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	33/197 (17%)
		ANF_receptor	42..379	CDD:279440	29/177 (16%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	107/431 (25%)
		Lig_chan	546..816	CDD:278489	65/290 (22%)
Ir84a	NP_649720.2	nt_trans	<54..>112	CDD:294020	9/64 (14%)
		Periplasmic_Binding_Protein_Type_2	222..583	CDD:304360	97/392 (25%)
		Lig_chan	355..602	CDD:278489	63/276 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840