DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK5 and Nmdar1

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	901	Identity:	229/901 - (25%)
Similarity:	381/901 - (42%)	Gaps:	171/901 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    51 INGII-EVPAKARVEVDIFELQRDSQY-------------------ETTDTMC-QILPKGVVSVL 94
            |.|:: ...::......|..|..|.||                   :|...:| :::...|.:|:
  Fly    41 IGGVLSNSDSEEHFSTTIKHLNFDQQYVPRKVTYYDKTIRMDKNPIKTVFNVCDKLIENRVYAVV 105

Human    95 ---GPSSSPASASTVSHICGEKEIPHIKVGPEETP------RLQYLRFASVSLYPSNEDVSLAVS 150
               ..:|...|.:.||:..|...||.|.:...:..      .:.:||  :|..|....||.|
  Fly   106 VSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLR--TVPPYYHQADVWL--- 165

Human   151 RILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLD--DSRDPTPLLKEIRDDKVST 213
            .:|..|.|....:|.:.       :...|..|...:|.|....|  |.|....|:.|. :.|:.:
  Fly   166 EMLSHFAYTKVIIIHSS-------DTDGRAILGRFQTTSQTYYDDVDVRATVELIVEF-EPKLES 222

Human   214 I---IID------------ANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSN 263
            .   :||            |:...:.:|.|.|.|..||...:.:|:|..
  Fly   223 FTEHLIDMKTAQSRVYLMYASTEDAQVIFRDAGEYNMTGEGHVWIVTEQ---------------- 271

Human   264 ILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIG 328
                ::|:.:   .|:.|..|.:....:.:..           :.|:|:|:.||::|:..::.|.
  Fly   272 ----ALFSNN---TPDGVLGLQLEHAHSDKGH-----------IRDSVYVLASAIKEMISNETIA 318

Human   329 VKPLAC-TSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQR--TNYTLRILEKSRQGHREIGV 390
            ..|..| .||..|..|..|..||:.....|.||:|.|:..|.|  ..|.:..:.:.::.| .:|.
  Fly   319 EAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKH-VVGK 382

Human   391 W-YSNRTLAMNATTLDINLSQ-------------TLANKTLVVTTILENPYVM------------ 429
            : |.:....|.   :.||.|:             .:....|.:.||.|.|:|.
  Fly   383 FSYDSMRAKMR---MRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCE 444

Human   430 --RRP-----NFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLY---------GAPEPN 478
              .||     |..|.:......|:|:|:|.||::.:.|.|.|.|..||.:         ||....
  Fly   445 PDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLR 509

Human   479 GSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPF 543
            ..|||::|||:| ::||:.||..||..||.:.|:|||||...||:||.: ...|.....|||.||
  Fly   510 KEWTGLIGELVN-ERADMIVAPLTINPERAEYIEFSKPFKYQGITILEK-KPSRSSTLVSFLQPF 572

Human   544 SPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQG 608
            |..:|:.::::...|:.||:|..|.||:..:.    |.......|....|.:::||..|..:..|
  Fly   573 SNTLWILVMVSVHVVALVLYLLDRFSPFGRFK----LSHSDSNEEKALNLSSAVWFAWGVLLNSG 633

Human   609 -SEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLA---DQTNIEYGT 669
             .|..||:.|.|.:..||..|.:||::||||||||||.::|.:..:...:|..   ...|:...|
  Fly   634 IGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCAT 698

Human   670 IHAGSTMTFFQ-----NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEY 729
            :...|...:|:     ::.|:|.:.. ||..::|.   ::..::|      ...||:.:|:..||
  Fly   699 VKGSSVDMYFRRQVELSNMYRTMEAN-NYATAEQA---IQDVKKG------KLMAFIWDSSRLEY 753

Human   730 HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKE-- 792
            ....:|.|...|.|....|||||:..|||:.|.:|||||:..|:..:|.|.::|...|...:.
  Fly   754 EASKDCELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKLDKQWIFHGHVQQNCE 818

Human   793 -EDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEETPALHPAA 847
             .:.....||::|:.|:||::..|:...|.:.::|.|:...:..:.:.......||
  Fly   819 LFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYKKHQVKKQKRLDIARHAA 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	82/398 (21%)
		ANF_receptor	42..379	CDD:279440	79/377 (21%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	130/407 (32%)
		Lig_chan	546..816	CDD:278489	81/281 (29%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	86/414 (21%)
		ANF_receptor	58..371	CDD:279440	77/359 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	131/416 (31%)
		HisJ	451..>558	CDD:223904	41/108 (38%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	49/140 (35%)
		Lig_chan	575..838	CDD:278489	80/276 (29%)
		CaM_bdg_C0	854..882	CDD:287524	3/21 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910