Protein Alignment GRIK5 and Ir76a

DIOPT Version :10

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 122/683 - (17%)
• Similarity: 206/683 - (30%)
• Gaps: 256/683 - (37%)

Human   323 RSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTN-YTLRILEKSRQGHR 386
            |.:.:...||.....:.|.:.:....|...::.|      ||..||...| :|||:.....:.|.
  Fly    40 RLETVHPMPLIIMDWHRWANRSDQDVYDYKIKED------EFEGKGIPYNDWTLRLTVAIERSHC 98

Human   387 E---------------------IGVWYSNRTLAMNATTLD---------------------INLS 409
            |                     ..:|.|.|...|...|.:                     :..|
  Fly    99 ETFIAFQEQIPEFARYFYHASIYSIWRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITS 163

Human   410 QTLANKTLVVTT--------ILENP-----YVMRRPNFQA-------------------LSGNE- 441
            |.|.:.|..:.|        ..:||     |:::|  |.|                   |.|.|
  Fly   164 QYLNSSTFEIKTNRFVGPRNFNKNPEPVEFYILQR--FDAKGTKATWETQSAMSSKMRNLKGREV 226

Human   442 -----------------------RF--------EGFCVDMLRELAELLRFRYRLRLVEDGLYGAP 475
                                   ||        :|..:.::....||.....::...|...:|..
  Fly   227 VIGIFDYKPFMLLDYEKPPLYYDRFMNTTDVTIDGTDIQLMLIFCELYNCTIQVDTSEPYDWGDI 291

Human   476 EPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 540
            ..|.|..|:||.:::|:. |..|....:..|..:.:|.:......|::.|... ..|...:...|
  Fly   292 YLNASGYGLVGMILDRRN-DYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPA-PNRLISWTLLL 354

Human   541 DPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWF------ 599
            .||...:|:.::|..|..|..|.:..|     |  .|..:.|           ||| |.
  Fly   355 RPFQFVLWMCVMLCLLLESLALGITRR-----W--EHSSVAA-----------GNS-WISSLRFG 400

Human   600 ---PVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD 661
               .:..|:.|.:..:..:.:.|.|....:...:|:.:.|:..|||.||:..:|...:|...|.|
  Fly   401 CISTLKLFVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFD 465

Human   662 QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTM 726
            ...|..||..|..|                                     .::.|.|..:...:
  Fly   466 HKLIWTGTSQAWIT-------------------------------------TIDERSADPVLLGL 493

Human   727 NEYHRRLNCNL-------TQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILK---- 780
            .|::|..:.||       .|:|.:::...:|   .||:          .:|.||:.|:.||
  Fly   494 MEHYRVYDANLISAFSHTEQMGFVVERLQFG---HLGN----------TELIENDALKRLKLMVD 545

Human   781 ------------RKW------------WEGGRCPK----------EEDHRAK------------- 798
                        |.|            |......|          ...||..
  Fly   546 DIYFAFTVAFVPRLWPHLNAYNDFILAWHSSGFDKFWEWKIAAEYMNAHRQNRIVASEKTNLDIG 610

Human   799 --GLGMENIGGIFIVLICGLIIAVFVAVMEFIW 829
              .||::|..|:.::...|:|.::...:.| :|
  Fly   611 PVKLGIDNFIGLILLWCFGMICSLLTFLGE-LW 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	20/99 (20%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	86/478 (18%)
Ir76a	NP_001097647.3	None