DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK5 and Ir75d

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	148/710 - (20%)
Similarity:	267/710 - (37%)	Gaps:	163/710 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   197 RDPTP-----------LLKEIRDDKV-STIIIDANASISHLILRKASELGMTSAFYKYILTTMDF 249
            :||.|           |:...|...| |.:::..:..|:...|.|..:....:.||..:.|....
  Fly    34 QDPDPKTRWGNQLPDMLVAYYRHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFYVQVSTESSL 98

Human   250 -PILHLDGIVE--DSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAV 311
             .:.|:|.:.|  |:.....|...|::|             |.     :::|.|||...:
  Fly    99 RDLQHVDALDEHKDAPPPKSFHANNSTH-------------WE-----TSFLLPALPYKM----- 140

Human   312 HVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLR 376
                 .:..|..|.|..:..|..::|:...:.|:...:|.:.|..|....:|........:..||
  Fly   141 -----GILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLLEDPEIFIPPDSELR 200

Human   377 ILEKSRQGH--------REIGVWYS-NRTLA-----------------MNATTLDINLSQTLANK 415
            :|.....|:        .::..|.. .|||.                 .:|.|...:|...:.|.
  Fly   201 VLHYENVGNFSCSLIDLYKVAAWKPLKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNS 265

Human   416 TLVVT--TILENPYVMRRPNFQALSG-NERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP 477
            .:|:.  .:..|...:...:...:|. |.|       ::.|||..|...|......:  ||..:|
  Fly   266 AIVIAFPDLFTNIEDLSLRHIDTISKVNHR-------LMLELANRLNMSYNTYQTVN--YGWRQP 321

Human   478 NGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMG---RKPGYFS- 538
            |||:.|::|. ..|.:.|||..|..:..:|..::||        ::..|||..|   |:|...:
  Fly   322 NGSFDGLMGR-FQRYELDLAQLAIFMRLDRIALVDF--------VAETYRVRAGIMFRQPPLSAV 377

Human   539 ---FLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFP 600
               |..||...||:.:|:..:..:.||.|....||:.            |.:....|| |.:|
  Fly   378 ANIFAMPFENDVWVSILMLLIITTVVLVLELFFSPHN------------HDMSYMDTL-NFVW-- 427

Human   601 VGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD--QT 663
             |...|||..:..|..|.|.:....:...|.:.:|::||:.|.|     :.|.::...|:|  |:
  Fly   428 -GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL-----QSPSDAIQSLSDLGQS 486

Human   664 NIEYGTIHAGSTMTFFQNSRYQTYQRMWN-YMQSKQPSVFVKSTEEGIARVLNSRYAFLLE---- 723
            .:|.|.........:|..|.....:.::: .:.||..:::::.. .|:.::....:|:.:|
  Fly   487 PLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPL-LGMEKMRTGLFAYQVELQAG 550

Human   724 -----STMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAIL---QLQENNRLEIL- 779
                 .|.:|..:   |      ||::.:.:.:.| |..|.|.......|   ||:....:.::
  Fly   551 YQIVSDTFSEPEK---C------GLMELEPFQLPM-LAIPTRKNFPYKELIRRQLRWQREVSLVN 605

Human   780 --KRKWWEGGRCPKEEDHRAKGLGMENIG--------GIFIVLICGLIIAVFVAVMEFIW 829
              :|||     .|::........|..:||        |||   .||..::..:.:.|||:
  Fly   606 REERKW-----IPQKPKCEGGVGGFVSIGITECRYALGIF---GCGAAVSFVLFLFEFIF 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	43/242 (18%)
		ANF_receptor	42..379	CDD:279440	37/196 (19%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	90/398 (23%)
		Lig_chan	546..816	CDD:278489	62/295 (21%)
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	58/215 (27%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	62/295 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840