Protein Alignment GRIK5 and Ir75c

DIOPT Version :10

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Alignment Length: 476
• Identity: 104/476 - (21%)
• Similarity: 180/476 - (37%)
• Gaps: 109/476 - (22%)

Human   397 LAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALS--GNERFEGFCVDMLRELAELLR 459
            ||...:.|.||.|:         ..:||.....|..:..::|  ||.        ::....|:|.
  Fly   200 LAALVSVLPINSSE---------EELLEFLNSDRDSHMDSISRIGNR--------LIMHTQEILG 247

Human   460 FRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAF-------------TITAEREKVI 511
            |  :|..:..|.:...:..|   |.:|.|.| :.|:|....|             |..|:...|.
  Fly   248 F--KLHYIWCGTWSVQDAFG---GAIGMLTN-ESAELCTTPFVPSWNRLHYLHPMTEQAQFRAVC 306

Human   512 DFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNP 576
            .|..|.           :.|.|...  ||:||.|:||.......:....:|::...|..: |.
  Fly   307 MFRTPH-----------NAGIKAAV--FLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERH-WM-- 355

Human   577 HPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISS------ 635
            ..||...|.:|       :|.....|....|||.:||::...|.      ||..::::|
  Fly   356 QRCLDFIPSLL-------SSCLISFGAACIQGSYLMPKSAGGRL------AFIAVMLTSFLMYNY 407

Human   636 YTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNY-MQSKQ- 698
            ||:.:.:.|....:...:.:...||| ::::.|......|.|:..:|.....:.::.. ::||:
  Fly   408 YTSIVVSTLLGSPVRSNIRTIQQLAD-SSLDVGFDTVPFTKTYLVSSPRPDIRSLYKQKVESKRD 471

Human   699 PSVFVKSTEEGIAR-------VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLG 756
            |:....|.|||:.|       |..|..:|:.......|..|...:|.:|....::..||: :.|.
  Fly   472 PNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIILRPESAVYGM-VHLN 535

Human   757 SPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAK------------GLGMENIGGIF 809
            |.:|..:|    |||.         :..|.|...|:....:|            .:|||....:|
  Fly   536 STYRQLLT----QLQV---------RMLETGITSKQSRFFSKTKLHTFSNSFVIQVGMEYAAPLF 587

Human   810 IVLICGLIIAVFVAVMEFIWS 830
            |.|:....:|:.:.::|..|:
  Fly   588 ISLLVAYFLALLILILEICWA 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	2/3 (67%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	85/400 (21%)
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	41/196 (21%)