DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GRIK5 and Ir68b

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_648548.1	Gene:	Ir68b / 39378	FlyBaseID:	FBgn0036250	Length:	635	Species:	Drosophila melanogaster

Alignment Length:	391	Identity:	81/391 - (20%)
Similarity:	136/391 - (34%)	Gaps:	104/391 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   438 SGNERFEGFCVDMLRELAELLRFRYRLRLVEDG-LYGAPEPNGSWTGMVGELINRQKADLAVAAF 501
            :|.:..:|...   |.:.|:|.........||. .||...|||::||:|.::         |...
  Fly   213 AGYQAVDGVAA---RVVGEMLNASVTYVFPEDNESYGRCLPNGNYTGVVSDI---------VGGH 265

Human   502 TITAEREK-VIDFSKPFMTLGISILY-----RVHM-----GRKPGYFSFLDPFSPAVWLFMLLAY 555
            |..|...: |:|...|    .:.:||     .:|:     ..:|.|..|:..|...||..:|:..
  Fly   266 THFAPNSRFVLDCIWP----AVEVLYPYTRRNLHLVVPASAIQPEYLIFVRVFRRTVWYLLLVTL 326

Human   556 LAVSCVLFLAARLSPYEWYNPHPCLRARPH--ILENQYTLGNSLWFPV------------GGFMQ 606
            |.|..|.::..||.           |..|.  :::.|.|     |:.:            .|.:.
  Fly   327 LVVVLVFWVMQRLQ-----------RRIPRRGVIQFQAT-----WYEILEMFGKTHVGEPAGRLS 375

Human   607 QGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIH 671
            ..|       |.|.....|..|:.::.:.|.|.|.:.......|..|:..|||.      :..:|
  Fly   376 SFS-------SMRTFLMGWILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDLV------HLDVH 427

Human   672 AGSTMTFFQNSRYQTYQRMWNYMQSKQ---PSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRL 733
            ..:..|.:...|....:..:..::::.   |.....|..:.:.|..:.|.||:    |.::|.|.
  Fly   428 IYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFI----MRDFHARD 488

Human   734 NCNLTQIGGLLDTKGYGIG------------MPLGSPFRDEITLAILQLQENNRLEILKRKWWEG 786
            ...:| .....:...|.|.            :|.||||.             :|||.|...:.|.
  Fly   489 FLAIT-YDSQAERPAYHIAREYLRSMICTYILPRGSPFL-------------HRLESLYSGFLEH 539

Human   787 G 787
            |
  Fly   540 G 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389
		ANF_receptor	42..379	CDD:279440
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	79/387 (20%)
		Lig_chan	546..816	CDD:278489	53/271 (20%)
Ir68b	NP_648548.1	Lig_chan	333..607	CDD:278489	47/255 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840