Protein Alignment GRIK5 and Ir68a

DIOPT Version :10

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 123/642 - (19%)
• Similarity: 222/642 - (34%)
• Gaps: 205/642 - (31%)

Human   355 YDGLTGRVEFNSKGQ--------RTNYTLRILEKSR-------------------------QGHR 386
            ||    |:.|.|.|:        |||.:..:...||                         |..|
  Fly    66 YD----RIFFESVGRRVIPFFVMRTNESDDLQRPSRQVELFVKAIKSSDCELNVITILNGWQVQR 126

Human   387 EIGVWYSNRTLAMN--------------------ATTLD-INLSQTLANK----TLVVTTILENP 426
            .:|..|.||:|.|.                    :..:| |.|.:.|.||    |:....||...
  Fly   127 FLGYIYDNRSLNMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGV 191

Human   427 YVMRR-PNFQ---ALSG--------------------------------NERFEGFCVDMLRELA 455
            .||:. .|::   .|:|                                .:.|:|..|:::..|.
  Fly   192 LVMKNIANWELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWANATKSFQGVEVEIMNALG 256

Human   456 ELLRFR---YRLRLVE-------DG----LYGAPEPNG-SWTG-----MVGELINRQKADLAVAA 500
            :.|.|:   |:....|       ||    .||:..|:| :..|     |:.:.:....|..|:..
  Fly   257 KALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGD 321

Human   501 FTITAEREKVIDFSKP-------FMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAV 558
            ..:.....|:::.|.|       |:|        ........:.:|:.|||..:|:.:||:...|
  Fly   322 LHLFQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGMWVGVLLSLFVV 378

Human   559 SCVLFLAARLSPY-------EWYNPHPCLRAR------------------------------PHI 586
            ..|.:..:.|:..       |::.   |||..                              |..
  Fly   379 GTVFYAISFLNAIINGNVSSEFFR---CLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRD 440

Human   587 LENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEV 651
            |.:.||  |.:.......:......|||....|.::|.:|.:.::::::|.|:..|.|......|
  Fly   441 LFDGYT--NCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARV 503

Human   652 PVESADDLADQTNIEYGTIHAGST--MTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVL 714
            .:::.:||. :::|...|   |:|  ..||..:..:..:::...|:     ||..| ::..:|:.
  Fly   504 TIDTLEDLL-RSHIPPST---GATENRQFFLEANDEVARKVGEKME-----VFGYS-DDLTSRIA 558

Human   715 NSRYAFLLESTMNEYHRRLNCNLTQIGGLLD-TKGYGIGMPL------GSPFRDEITLAILQLQE 772
            ..:.|:.    .||::.|......:.|..|. .|...:.||:      .|..:..:..:|..|.|
  Fly   559 KGQCAYY----DNEFYLRYLRVADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAE 619

Human   773 NNRLEILKRKWWEGG--RCPKEEDHRAKGL-GMENIGGIFIVLICGLIIAVFVAVME 826
            ..    |..||.:..  ..|.|...:.:.| .::.....|:.|:.|.:|::...:.|
  Fly   620 GG----LIAKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAE 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	19/98 (19%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	92/483 (19%)
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	60/316 (19%)