DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRIK5 and GluRIA

DIOPT Version :9

Sequence 1:XP_011525167.1 Gene:GRIK5 / 2901 HGNCID:4583 Length:982 Species:Homo sapiens
Sequence 2:NP_476855.1 Gene:GluRIA / 38742 FlyBaseID:FBgn0004619 Length:991 Species:Drosophila melanogaster


Alignment Length:1005 Identity:317/1005 - (31%)
Similarity:491/1005 - (48%) Gaps:178/1005 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    13 FASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYE 77
            |...:..|.|:.:.|.:..:..|..|         |.::...::|...|    |.|:|.|     
  Fly    46 FEQGTDDVQSAFKYAMLNHNLNVSSR---------RFELQAYVDVINTA----DAFKLSR----- 92

Human    78 TTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYLRFASVSLY 139
               .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  .|....|.|| :|:.
  Fly    93 ---LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFA-ISMR 152

Human   140 PSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT---- 200
            |   |...|:...::.:.:.|...:....:.||||:::.:......||..|:|:....:.|    
  Fly   153 P---DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIE 214

Human   201 --PLLKEIRDDKVSTIIIDANASIS-HLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSS 262
              ..|:::.......|::|..|.:: .:|::...::.:....|.|:|:          |:|.|:.
  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLS----------GLVMDNH 269

Human   263 -----------NILGFSMFNTSHPFYPEF------VRSLNMSWRENCEASTYLGPALS--AALMF 308
                       ||.||.:.:::.....:|      :.....|..:|......| ||:|  ||||:
  Fly   270 WPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSL-PAISAQAALMY 333

Human   309 DAVHVVVSAV-------------RELNRSQEIGVKPLACTSAN----------------IWPHGT 344
            |||.|:|.|.             ..|.|....|....:.|..|                .|..|.
  Fly   334 DAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGE 398

Human   345 SLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS-RQGHREIGVW-------------YSNR 395
            .:...||.||.|||:|.:.|:..|:|.||||.::|.| ....:::..|             |::.
  Fly   399 KISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASS 463

Human   396 TLAMNATTLDINLSQTLANKTLVVTTILENPYV-MRRPNF-QALSGNERFEGFCVDMLRELAELL 458
            :.:.:|:|.|.:     .|.|.:|:::||.||: :::..: ::|.||:||||:|.|:...||..|
  Fly   464 SRSASASTGDYD-----RNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQL 523

Human   459 RFRYRLRLVEDGLYGAPE--PNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLG 521
            ..:|.:|||:||.|||..  ..|.|.||||||| |::||:|::|.|||||||:||||||||||||
  Fly   524 GIKYEIRLVQDGNYGAENQYAPGGWDGMVGELI-RKEADIAISAMTITAERERVIDFSKPFMTLG 587

Human   522 ISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW---YNPHPCLRAR 583
            |||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:...|..||||   ..|.....|:
  Fly   588 ISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQ 652

Human   584 ------------------PHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTL 630
                              |.:..|::|:.||.|:.:..|||||.:|.|.:::.|..:.|||.||:
  Fly   653 QPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTI 717

Human   631 IIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQ 695
            |:||||||||||||||:||..|:::.:||..||::.|||:..|||..||:.|:...:.:||.||.
  Fly   718 ILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMN 782

Human   696 SKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGS 757
            :.|.. .|.:.:|||.||..|  :||.|:||..||| :.|..|:..::|..:||||:|:..|:||
  Fly   783 ANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGS 846

Human   758 PFRDEITLAILQLQENNRLEILKRKWW-EGGRCP-KEEDHRAKGLGMENIGGIFIVLICGLIIAV 820
            |.|..:..|:|.|:||..|..::.||| :...|. .:|......|.:.|:.||:.:||.||::||
  Fly   847 PLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAV 911

Human   821 FVAVMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQVAFSRTSLRQ 885
            .||:|||....:       ||.|.......||.|              ||.......:.|.||..
  Fly   912 IVAIMEFFCRNK-------TPQLKSPGSNGSAGG--------------VPGMLASSTYQRDSLSD 955

Human   886 VCPFLLQH-------QLSSLYWIQATNVQI 908
            .    :.|       |.||.|..:...|::
  Fly   956 A----IMHSQAKLAMQASSEYDERLVGVEL 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRIK5XP_011525167.1 PBP1_iGluR_Kainate_KA1_2 25..399 CDD:107389 99/445 (22%)
ANF_receptor 42..379 CDD:279440 92/394 (23%)
Periplasmic_Binding_Protein_Type_2 414..785 CDD:304360 178/399 (45%)
Lig_chan 546..816 CDD:278489 114/295 (39%)
GluRIANP_476855.1 PBP1_iGluR_AMPA 41..453 CDD:107375 101/443 (23%)
ANF_receptor 53..434 CDD:279440 97/417 (23%)
PBP2_iGluR_AMPA 477..879 CDD:270433 178/403 (44%)
Lig_chan 612..907 CDD:278489 114/295 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155751
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60082
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100167
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7871
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.780

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