Protein Alignment GRIK5 and GluRIA

DIOPT Version :10

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Alignment Length: 1005
• Identity: 317/1005 - (31%)
• Similarity: 491/1005 - (48%)
• Gaps: 178/1005 - (17%)

Human    13 FASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYE 77
            |...:..|.|:.:.|.:..:..|..|         |.::...::|...|    |.|:|.|
  Fly    46 FEQGTDDVQSAFKYAMLNHNLNVSSR---------RFELQAYVDVINTA----DAFKLSR----- 92

Human    78 TTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG-PEE--TPRLQYLRFASVSLY 139
               .:|....:||.|:|| :.||.|..|:.......::|.:... ||:  .|....|.|| :|:.
  Fly    93 ---LICNQFSRGVYSMLG-AVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFA-ISMR 152

Human   140 PSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT---- 200
            |   |...|:...::.:.:.|...:....:.||||:::.:......||..|:|:....:.|
  Fly   153 P---DYHQAIIDTIQYYGWQSIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIE 214

Human   201 --PLLKEIRDDKVSTIIIDANASIS-HLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSS 262
              ..|:::.......|::|..|.:: .:|::...::.:....|.|:|:          |:|.|:.
  Fly   215 FLHTLEDLGRFSKKRIVLDCPAEMAKEIIVQHVRDIKLGRRTYHYLLS----------GLVMDNH 269

Human   263 -----------NILGFSMFNTSHPFYPEF------VRSLNMSWRENCEASTYLGPALS--AALMF 308
                       ||.||.:.:::.....:|      :.....|..:|......| ||:|  ||||:
  Fly   270 WPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEPSGQSQSQNAGGPNSL-PAISAQAALMY 333

Human   309 DAVHVVVSAV-------------RELNRSQEIGVKPLACTSAN----------------IWPHGT 344
            |||.|:|.|.             ..|.|....|....:.|..|                .|..|.
  Fly   334 DAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGE 398

Human   345 SLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS-RQGHREIGVW-------------YSNR 395
            .:...||.||.|||:|.:.|:..|:|.||||.::|.| ....:::..|             |::.
  Fly   399 KISRVLRKVEIDGLSGEIRFDEDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASS 463

Human   396 TLAMNATTLDINLSQTLANKTLVVTTILENPYV-MRRPNF-QALSGNERFEGFCVDMLRELAELL 458
            :.:.:|:|.|.:     .|.|.:|:::||.||: :::..: ::|.||:||||:|.|:...||..|
  Fly   464 SRSASASTGDYD-----RNHTYIVSSLLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQL 523

Human   459 RFRYRLRLVEDGLYGAPE--PNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLG 521
            ..:|.:|||:||.|||..  ..|.|.||||||| |::||:|::|.|||||||:||||||||||||
  Fly   524 GIKYEIRLVQDGNYGAENQYAPGGWDGMVGELI-RKEADIAISAMTITAERERVIDFSKPFMTLG 587

Human   522 ISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW---YNPHPCLRAR 583
            |||:.:..:.:.||.||||:|.|..:|:.::|:|:.||.||:...|..||||   ..|.....|:
  Fly   588 ISIMIKKPVKQTPGVFSFLNPLSQEIWISVILSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQ 652

Human   584 ------------------PHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTL 630
                              |.:..|::|:.||.|:.:..|||||.:|.|.:::.|..:.|||.||:
  Fly   653 QPPGIIGGATLSEPQAHVPPVPPNEFTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTI 717

Human   631 IIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQ 695
            |:||||||||||||||:||..|:::.:||..||::.|||:..|||..||:.|:...:.:||.||.
  Fly   718 ILISSYTANLAAFLTVERMVAPIKTPEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMN 782

Human   696 SKQPSVFVKSTEEGIARVLNS--RYAFLLESTMNEY-HRRLNCNLTQIGGLLDTKGYGIGMPLGS 757
            :.|.. .|.:.:|||.||..|  :||.|:||..||| :.|..|:..::|..:||||:|:..|:||
  Fly   783 ANQHH-SVHTYDEGIRRVRQSKGKYALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGS 846

Human   758 PFRDEITLAILQLQENNRLEILKRKWW-EGGRCP-KEEDHRAKGLGMENIGGIFIVLICGLIIAV 820
            |.|..:..|:|.|:||..|..::.||| :...|. .:|......|.:.|:.||:.:||.||::||
  Fly   847 PLRKRLNEAVLTLKENGELLRIRNKWWFDKTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAV 911

Human   821 FVAVMEFIWSTRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQVAFSRTSLRQ 885
            .||:|||....:       ||.|.......||.|              ||.......:.|.||..
  Fly   912 IVAIMEFFCRNK-------TPQLKSPGSNGSAGG--------------VPGMLASSTYQRDSLSD 955

Human   886 VCPFLLQH-------QLSSLYWIQATNVQI 908
            .    :.|       |.||.|..:...|::
  Fly   956 A----IMHSQAKLAMQASSEYDERLVGVEL 981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	99/449 (22%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	178/399 (45%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	101/446 (23%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	178/403 (44%)
		Lig_chan	610..906	CDD:459656	115/296 (39%)