DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK5 and Ir64a

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	699	Identity:	126/699 - (18%)
Similarity:	217/699 - (31%)	Gaps:	226/699 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   275 PFYPEFVRSLNMSWRENCEASTYLGPALS-AALMFDAVHVVVSAVRELNRSQEIGVKPLACTSAN 338
            |....|:..:|:          |:...|: |..|.:|.|.                     |..:
  Fly   230 PSIESFLGGMNL----------YMNTELTLAKRMSEAAHY---------------------TLFD 263

Human   339 IWPHGTSLMNYLRMVEY------DGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTL 397
            :|..|.:...::.:.|.      :|:.....|     ||..|:|.....:.......|..:|:.:
  Fly   264 VWNPGLNYGGHVNLTEIGSFTPTEGIQLHTWF-----RTTSTVRRRMDMQHARVRCMVVVTNKNM 323

Human   398 AMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRY 462
               ..||...|:.|::..   :.|       |.|.||..|..           :|::     |.:
  Fly   324 ---TGTLMYYLTHTMSGH---IDT-------MNRFNFNLLMA-----------VRDM-----FNW 359

Human   463 RLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYR 527
            ...|.....:|..: ||.:.||:|.|| |.:.|:..|......||.|.||.:....:.....::|
  Fly   360 TFVLSRTTSWGYVK-NGRFDGMIGALI-RNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFR 422

Human   528 VHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSC---VLFLAARLSPYEW-YNPH-------PCLR 581
            .....:.....||.||:..||:      |.|.|   .:|:...|:..|| ..||       |...
  Fly   423 HPRSTQKDRIVFLQPFTNDVWI------LIVGCGVLTVFILWFLTTIEWKLVPHDGSALIKPKGG 481

Human   582 ARPH------------------------------ILENQYTLGNS-------LW----------- 598
            |.|.                              :.|.|....:|       ||
  Fly   482 APPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYI 546

Human   599 ----------------------FPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLA 641
                                  |.||...|||.......:|.||:......|:..|...|:|::.
  Fly   547 KDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIV 611

Human   642 AFLTVQRMEVPVESADDLA----------------------DQTNIEYGTIHAGSTMTFFQNSR- 683
            ..|.:::.:. :::..||.                      |..::|.......|..|..:|..
  Fly   612 GTLLMEKPKT-IKTLSDLVHSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEAD 675

Human   684 --------------YQTYQRMWNYMQSKQPSVFVKST--------EEGIARVLNSRYAF------ 720
                          .::|:   :.:.|.:.....|..        |.|:.|.|.  :||
  Fly   676 EDEPVDPNPVSTDPAKSYR---DIVHSHETGAHAKDNAASNWLDPETGLLRHLG--FAFHVDVAA 735

Human   721 ---LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRK 782
               ::..|.:|..   .|:||::......|...| |...||.|..|:..:.::.|...|......
  Fly   736 AYKIIAETFSEQD---ICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHFNV 796

Human   783 WW-EGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWS 830
            |. ....|.|:.:.....:.|:.:....::|:....|.:.:...|.::|
  Fly   797 WHSRKPPCVKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILYS 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	21/130 (16%)
		ANF_receptor	42..379	CDD:279440	19/110 (17%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	94/506 (19%)
		Lig_chan	546..816	CDD:278489	68/405 (17%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	31/137 (23%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	48/274 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840