Protein Alignment GRIK5 and Ir40a

DIOPT Version :9

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 784
• Identity: 143/784 - (18%)
• Similarity: 259/784 - (33%)
• Gaps: 225/784 - (28%)

Human   167 KAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKAS 231
            :::..:.|.::|||  :.:.:|::..|     |:..|.:....|...:.:|......|....|:.
  Fly    29 ESDTAIALTQIVRG--LQQSSLAILAL-----PSLALSDGVCQKERNVYLDDFLQRLHRSNYKSV 86

Human   232 ELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILG--FSMFNTSHPFYPEFVRSLNMSWRENCEA 294
            ....|..|:::|..       :|.|..|..|.||.  ..:.|:.|
  Fly    87 VFSQTELFFQHIEE-------NLQGANECISLILDEPNQLLNSLH-------------------- 124

Human   295 STYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLT 359
            ..:||..||..:.:....                           ||..:.::.:...:....:|
  Fly   125 DRHLGHRLSLFIFYWGAR---------------------------WPPSSRVIRFREPLRVVVVT 162

Human   360 G------RVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLAN---K 415
            .      |:.:|.....::..|:::.           ||....|.:....|........||   :
  Fly   163 RPRKKAFRIYYNQARPCSDSQLQLVN-----------WYDGDNLGLQRIPLLPTALSVYANFKGR 216

Human   416 TLVVTTILENPYVMRRPNFQALSGNERFE--------------------GFCVDMLRELAELLRF 460
            |..| .:..:|     |.|.....|..||                    |....:|..|::.:.|
  Fly   217 TFRV-PVFHSP-----PWFWVTYCNNSFEEDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNF 275

Human   461 RYR-----------LRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFS 514
            |::           :| .|||    .:.|.|:||.:| |:...:||..:....::.||.|.|:||
  Fly   276 RFKYIEAPGRTQGSMR-SEDG----KDSNDSFTGGIG-LLQSGQADFFLGDVGLSWERRKAIEFS 334

Human   515 KPFMTLGISILYRVHMGRKPG-YFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW----- 573
              |.||..|..:..|..|:.. ..:.:.||...:|..::|. :..|..:|......||.|
  Fly   335 --FFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPHLILT-IIFSGPIFYGIIALPYIWRRRWA 396

Human   574 --------------------------YNPHPCLRAR--PHILENQYTLGNSLWFPVGGFMQQGSE 610
                                      ..|...|.|.  ||.|     ....:||.:..|::|...
  Fly   397 NSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQL-----FQKCIWFTLRLFLKQSCN 456

Human   611 IMPRALSTRCVSGVWW-AFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAG- 673
            .:......:.::.|:| |.|.::...|:|.|.:.......|.|:.:..      .::...||.|
  Fly   457 ELHNGYRAKFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQ------RLQAAMIHDGY 515

Human   674 --------STMTFFQNSR---YQTYQRMWNYMQSKQPSVFVKSTEEGI---------ARVLNSRY 718
                    |::...:|..   .|.|..|...:.:.....|:.|.|.||         ..||..|.
  Fly   516 RLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRE 580

Human   719 AFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRL------- 776
            ....  .:.:|    ..|..|:...|.|:...:.:.:|.||...:...::||.|:..|
  Fly   581 TLFF--NVQQY----GSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAE 639

Human   777 ------EILKRKWWEGGRCPKEEDHRAK----------GLGMENIGGIFIVLICGLIIAVFVAVM 825
                  |:...:.::|....|..:..::          .|.:..:.|.||.|..|.:.|..:.::
  Fly   640 YAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLL 704

Human   826 EFIW 829
            |.::
  Fly   705 EIVF 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	36/239 (15%)
		ANF_receptor	42..379	CDD:279440	33/219 (15%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	95/473 (20%)
		Lig_chan	546..816	CDD:278489	62/347 (18%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	32/135 (24%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	28/97 (29%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	30/152 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840