Protein Alignment GRIK5 and Ir25a

DIOPT Version :9

• Sequence 1: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 923
• Identity: 233/923 - (25%)
• Similarity: 402/923 - (43%)
• Gaps: 182/923 - (19%)

Human    51 INGIIEVPAKARVEVDIFELQRDSQY---------ETTDTMCQILPKGVVS-------------- 92
            ||.:...||...|||.:..|:::.:|         |...:..::|.:.:.:
  Fly    41 INEVDNEPAAKAVEVVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHL 105

Human    93 VLGPSSSPASASTVSHICGEKEIPHIKV--GPE---------ETPRLQYLRFASVSLYPSNEDVS 146
            :|..:.|..::.||........:|.|..  |.:         :..:.:||    :.:.|..:.:.
  Fly   106 ILDTTKSGIASETVKSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYL----LQVMPPADIIP 166

Human   147 LAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKV 211
            .|:..|:...|..:|:::...:..:....:.:...:.::..::....|..|:....::::|:..:
  Fly   167 EAIRSIVIHMNITNAAILYDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDI 231

Human   212 STIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPF 276
            :...|........::|...........|..:.:|..:..|    ....|::.|:  .|...::..
  Fly   232 NNFFILGTLQSIRMVLESVKPAYFERNFAWHAITQNEGEI----SSQRDNATIM--FMKPMAYTQ 290

Human   277 YPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWP 341
            |.:.:..|..::..|.|      |.||:|..||........::|:.:|             ..||
  Fly   291 YRDRLGLLRTTYNLNEE------PQLSSAFYFDLALRSFLTIKEMLQS-------------GAWP 336

Human   342 HGTSLMNYLRMVEYDG-------LTGRVEFNSKGQRTNY-TLRILEKSRQ---GH---------- 385
            ..   |.||...::.|       |..|..|....:.|:| |..::.:|.|   ||
  Fly   337 KD---MEYLNCDDFQGGNTPQRNLDLRDYFTKITEPTSYGTFDLVTQSTQPFNGHSFMKFEMDIN 398

Human   386 ------------REIGVWYSNRTLAMNATTL---DINLSQTLANKTLVVTTILENPYVMRRPNFQ 435
                        :.||.|.|    .:|:..:   :..:....|:....:.|:::.|::||..
  Fly   399 VLQIRGGSSVNSKSIGKWIS----GLNSELIVKDEEQMKNLTADTVYRIFTVVQAPFIMRDE--- 456

Human   436 ALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500
              :..:.::|:|:|::.|:|.::.|.|.::.||||.:|..:.||.|.|:|.:|:::| ||:.:.:
  Fly   457 --TAPKGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENGQWNGIVKKLMDKQ-ADIGLGS 518

Human   501 FTITAEREKVIDFSKPFMTL-GISILYRVHMGRKP----GYFSFLDPFSPAVWLFMLLAYLAVSC 560
            .::.||||.||||:.|:..| ||:|     |.::|    ..|.||......|||.:|.||...|.
  Fly   519 MSVMAEREIVIDFTVPYYDLVGITI-----MMQRPSSPSSLFKFLTVLETNVWLCILAAYFFTSF 578

Human   561 VLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW 625
            ::::..|.|||.:.|...  :.:....:.::.|...|||.:.....||....|:.||.|.|:..|
  Fly   579 LMWIFDRWSPYSYQNNRE--KYKDDEEKREFNLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATW 641

Human   626 WAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSR------Y 684
            |.|..|||:||||||||||||.|::.||||.||||.|..|.|..::..|.||:|:...      |
  Fly   642 WLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSAMTYFERMSNIEQMFY 706

Human   685 Q----------------------------TYQRMWNYMQ-SKQPSVFVKSTEEGIARVLNSR--- 717
            :                            .|.:||..|| :|.|:    :.:|.:|||.||.
  Fly   707 EIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQEAKLPA----TLDEAVARVRNSTAAT 767

Human   718 -YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKR 781
             :|||.::|...|.:..||:|..:|.....|.|.|.:..||..:|:...|||.|....:||.||.
  Fly   768 GFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAILTLLNKRQLEKLKE 832

Human   782 KWWEG----GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRR--------- 833
            |||:.    .:|.|.|| ::.|:.::||||:|||:..|:.:|....|.|:.|...|
  Fly   833 KWWKNDEALAKCDKPED-QSDGISIQNIGGVFIVIFVGIGMACITLVFEYWWYRYRKNPRIIDVA 896

Human   834 SAESEETPAL-HP 845
            .|.:|.:.|. ||
  Fly   897 EANAERSNAADHP 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	68/414 (16%)
		ANF_receptor	42..379	CDD:279440	60/369 (16%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	139/414 (34%)
		Lig_chan	546..816	CDD:278489	109/312 (35%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	69/420 (16%)
		PBP2_iGluR_putative	438..836	CDD:270435	139/414 (34%)
		Lig_chan	565..870	CDD:278489	109/311 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840