DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK5 and Ir8a

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	968	Identity:	227/968 - (23%)
Similarity:	381/968 - (39%)	Gaps:	263/968 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     5 LLLLLIVAFASPS-----------------------CQVLSSLRMAAILDDQTVCGRGERLALAL 46
            |:|||.:.||...                       .:.|.:||:...:||.|         |.|
  Fly     6 LVLLLALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELDALRLDVKVDDTT---------LTL 61

Human    47 AREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICG 111
            .|.:               |..::||         .|:||            |...||.|
  Fly    62 TRSE---------------DGLDMQR---------FCEIL------------STVGASAV----- 85

Human   112 EKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEE 176
                                             :.|..|...:.:|     |:.:.....:|||.
  Fly    86 ---------------------------------IDLTYSHWEEGYN-----LVRSLGIGYVRLER 112

Human   177 LVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHL-----------ILRKA 230
            ::|.||        .|..|      .:::.|.:.|:.:.::|..::..:           ::..|
  Fly   113 IMRPFL--------DMFGD------FMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDA 163

Human   231 SELGMTSAFYKYILTTMDFP--------ILHLDGIVEDSSNILGFSMFNTSHPFYPEFV----RS 283
            |:......|.:.|.:....|        ...::||.|   .:....:|  ..|....||    |.
  Fly   164 SQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFE---KVQKADLF--QRPLEWHFVFLDTRD 223

Human   284 LNMSWRENCEAST--YLGP-ALSAALMFDAVH----------VVVSAVREL-NRSQEIGVKPLA- 333
            ....:|...|..|  .|.| |:..::....::          ::::.:|.| |.:|.....|||
  Fly   224 RVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLAI 288

Human   334 -------CTSANIW-PHGTSLMNYLRMVEYDGLTG--------RVEFNSKGQRTNYTLRI----L 378
                   .:|:.:. |......|:|.||.:.....        :.:|.|......:.:.|    .
  Fly   289 YQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYY 353

Human   379 EKSRQGHREIGVWYSNRTLAMNATTLDINLSQTL--ANKTLVVTTILENP--YVMRRPNFQAL-- 437
            ....:...::..|.|...:.:        |::|:  |.:...:.|....|  |:.|......|
  Fly   354 SSEHEAKTDLAAWSSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIR 410

Human   438 --SGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQKADLAVAA 500
              ||...:||:|:|.:..|::.|.|.:.:...|.|..|.....|.|.|:||:|: |.:.|.|:||
  Fly   411 DRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLV-RGETDFAIAA 474

Human   501 FTITAEREKVIDFSKPFM-TLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFL 564
            ..:.:|||:||||..|:. ..||||..|..: |:...|.|:......|||.::.|.:..:.:::.
  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWF 538

Human   565 AARLSPYEWYN-----PHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGV 624
            ..:.|||...|     |:.|         .::||..|.||.:..|..||....|:|:|.|.:...
  Fly   539 MDKYSPYSSRNNRQAYPYAC---------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAA 594

Human   625 WWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRY--QTY 687
            :|.|.:::::::||||||||||:||:.||:|.:.||.|:.|.|..:....|..:|.|.::  .|.
  Fly   595 YWLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTL 659

Human   688 QRMWNYM-----------------------------QSKQPSVFVKSTEEGIARV---LNSRYAF 720
            .|||..:                             .|.||   |...:||.|.|   .|:.|||
  Fly   660 YRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAF 721

Human   721 LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE 785
            :.:|...:|....|||||::|.:...:.|.:.:..||...||::.|||:||::...|.||.|:|.
  Fly   722 IHDSAEIKYEITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWN 786

Human   786 GG---RCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEET 840
            ..   .||..||.  :|:.:|::||:||..:.||::|:....||.::..::....|.|
  Fly   787 QSNLPNCPLSEDQ--EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALEIT 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	69/431 (16%)
		ANF_receptor	42..379	CDD:279440	63/394 (16%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	129/416 (31%)
		Lig_chan	546..816	CDD:278489	96/311 (31%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	129/416 (31%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	96/311 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910