DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK5 and GluRIIE

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	880	Identity:	291/880 - (33%)
Similarity:	439/880 - (49%)	Gaps:	81/880 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    19 QVLSSLRMAAILDDQTVCGRGERLALALAREQINGI----IEVPAKARVEVDIFELQRD----SQ 75
            |.|.|:.:..:.|..|              ||:|.:    |:| |...|...:..|:.:    ..
  Fly    34 QSLESVPIGLLTDQNT--------------EQMNIVFDHAIDV-ANQEVGTSLTSLKEEVNYGDA 83

Human    76 YETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYP 140
            |::...:|::|..|:..|.||||...:...:| ||...:||||.....|...       ..:|:|
  Fly    84 YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICDAMDIPHIYSYMSENAE-------GFNLHP 140

Human   141 SNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT--PLL 203
            ...|::.|:..::..||:.....:...||.|..|.||......|...::|...|...:..  .:|
  Fly   141 HPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVL 205

Human   204 KEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFS 268
            :.:|....:.|::..::......|.:|.::|:.:..||||:..:||....|:......:||.|..
  Fly   206 RRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270

Human   269 MFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLA 333
            :|:.......|.:..|.....::...:......:..||.:|||.:....::.|      ..||:.
  Fly   271 LFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL------PFKPMP 329

Human   334 --CT--SANIWPHGTSLMNYLRMVEYDG--LTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVW- 391
              |:  :.::...|:|..||:|.:....  |||.:.|.. ..|..|.|.::|....|..::|.|
  Fly   330 QNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVIELQPSGIVKVGTWD 393

Human   392 ----YSNRTLAMNATTLDINLSQTLANKTLVVTTILEN-PYVMRRPNFQALSGNERFEGFCVDML 451
                |..:.||......| ::..:|||||.::...:.| ||......::.|.||.::||:.||::
  Fly   394 EDRQYRPQRLAPTTAQFD-SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLI 457

Human   452 RELAELLRFRYRLRLVEDGL-YGA--PEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDF 513
            :|||:.|.|.:  ..|..|. ||:  ...|.| |||:.|::. .:||||:...|||:|||:.:||
  Fly   458 KELADKLGFNF--TFVNGGNDYGSYNKSTNES-TGMLREIMT-GRADLAITDLTITSEREQALDF 518

Human   514 SKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHP 578
            :.|||.|||:|||.......|..|:|:||||..||.|:..::|.||...|:..||||.||.||:|
  Fly   519 TIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYP 583

Human   579 CLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAF 643
            |:. .|..||||:|||||:||..|..:||||||.|:|||||.|:..||.||||::||||||||||
  Fly   584 CIE-EPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAF 647

Human   644 LTVQRMEVPVESADDLAD-QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTE 707
            ||:::.:..:.|.||||| :..:.||....|||..||..|..:.|::| |...|:.|....:...
  Fly   648 LTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKM-NKFMSENPQYLTEDNM 711

Human   708 EGIARV-LNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQ 771
            ||:.|| .|:.||||:|||..||:.:..|||.:||..||.|||||.|....|.|.:...|:|:||
  Fly   712 EGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQ 776

Human   772 ENNRLEILKRKWWE---GGRCPKEED-HRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTR 832
            |...||.:|.|||.   .|.|..:|| ..|..|.|.|:.|:|.||:.|...|:...::.::....
  Fly   777 EQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVM 841

Human   833 RSAESEETPALHPAACQCSALGPRTPLKEPSMLLV 867
            :.|.....|.             |..|||....::
  Fly   842 KKAHHYRVPL-------------RDALKEEFQFVI 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	88/394 (22%)
		ANF_receptor	42..379	CDD:279440	80/352 (23%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	175/376 (47%)
		Lig_chan	546..816	CDD:278489	132/275 (48%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	86/383 (22%)
		ANF_receptor	51..382	CDD:279440	80/346 (23%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	175/376 (47%)
		Lig_chan	551..824	CDD:278489	132/274 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155979
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.760