DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRIK5 and Nmdar2

DIOPT Version :9

Sequence 1:XP_011525167.1 Gene:GRIK5 / 2901 HGNCID:4583 Length:982 Species:Homo sapiens
Sequence 2:NP_001014714.1 Gene:Nmdar2 / 31107 FlyBaseID:FBgn0053513 Length:1083 Species:Drosophila melanogaster


Alignment Length:1086 Identity:249/1086 - (22%)
Similarity:425/1086 - (39%) Gaps:256/1086 - (23%)


- Green bases have known domain annotations that are detailed below.


Human     2 PAELLLLLIVAFA---SPSCQVL------SSLRMAA----------ILDDQTVCGRGERLALALA 47
            |..||||.::...   :.|||.|      .||...|          ::...|..|:.|.|     
  Fly    59 PISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYL----- 118

Human    48 REQINGIIEVPAKAR----------------VEVDIFELQRDSQYETTDTMC-QILPKGVVSVLG 95
             ..||..:....|.|                :..|:..| ..|......|:| :.|...|.::|.
  Fly   119 -RSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSL-TPSPTAILSTLCKEFLRVNVSAILY 181

Human    96 PSS------SPASASTVSHICGEKEIPHI----------KVGPEETPRLQYLRFASVSLYPSNED 144
            ..:      |.|||.....:.|...||.|          :...:.|.:||        |.||.|.
  Fly   182 MMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQ--------LAPSIEH 238

Human   145 VSLAVSRILKSFNYPSASLIC-----------AKAECLLRLEELVRGFLISKETLSVRMLDDSRD 198
            .|.|:..||:.:.:...|::.           |..|.:..::|..: |.|....:..|..|    
  Fly   239 QSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFK-FTILNSIVVTRTSD---- 298

Human   199 PTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSN 263
                |.|:.:.:...:::.|..:.:..|||.|.|:.:|...|.::::         ..::|... 
  Fly   299 ----LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVS---------QSVIEKKD- 349

Human   264 ILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIG 328
                     :|..:|..:..::..     .:|..|...:|.|:...:..|........||.:.:.
  Fly   350 ---------AHSQFPVGMLGVHFD-----TSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLT 400

Human   329 VKPLAC--TSANIWPHGTSLMNYLRMVEYDGLTGR--VEFNSKGQRTNYTLRILEKSRQGH---- 385
            .:.|:|  .....|.:|.....|||.|..:|...:  :||.:.|...:..|:|:......:    
  Fly   401 TQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNL 465

Human   386 --REIGVWYSNRTLAMNATTLDIN----------LSQTLANK-TLVVTTILENPYVMRRPNFQAL 437
              .|||||.|..|     ..|||.          ..|.:..| .|.:|.:.|.||:...| ...:
  Fly   466 VWEEIGVWKSWET-----QKLDIRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSP-ADPV 524

Human   438 SG-----------------------------NERF----EGFCVDMLRELAELLRFRYRLRLVED 469
            ||                             ||.|    .|||:|:|.:.||.|.|.|.|..|||
  Fly   525 SGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVED 589

Human   470 GLYGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKP 534
            |.:|..| ||.|.|::.:|:|| |.|:.:.:..|..|||.|:|||:|||..||:|:    :.::.
  Fly   590 GKWGTLE-NGKWNGLIADLVNR-KTDMVLTSLMINTEREAVVDFSEPFMETGIAIV----VAKRT 648

Human   535 GYFS---FLDPFSPAVWLFM-LLAYLAVSCVLFLAARLSPYEWYNPH----PCLRARPHILENQY 591
            |..|   ||:||..|.|:.: ::|..|.:.::||      :||.:|.    .......::...::
  Fly   649 GIISPTAFLEPFDTASWMLVGIVAIQAATFMIFL------FEWLSPSGYDMKLYLQNTNVTPYRF 707

Human   592 TLGNSLWFPVGGFMQQGSEI-MPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVES 655
            :|..:.|.......|....: .||..::|.::.||..|.::.::.||||||||:..:........
  Fly   708 SLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSG 772

Human   656 ADD------LADQTNIEYGTI---HAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIA 711
            .:|      .:.:.:.::|||   |..||:       ::.:..|.|||:....:    |..:|:|
  Fly   773 LNDSRLVHPFSHKPSFKFGTIPYSHTDSTI-------HKYFNVMHNYMRQYNKT----SVADGVA 826

Human   712 RVLNSRY-AFLLESTMNEY--HRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQEN 773
            .|||... :|:.:.|:.:|  .:..:|.|..:|......|||:.....|.:.......:|:.:.|
  Fly   827 AVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRAN 891

Human   774 NRLEILKRKWWEGGRCPKEEDHRAKG-LGMENIGGIFIVLICGLIIAVFVAVMEFIW-------- 829
            ..||.|:|.|..|...|.:::|::.. |.:|.....|::|:.|:::|..:.::|.::        
  Fly   892 GDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRL 956

Human   830 -------------------STRRSAESEETPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQ 875
                               .|.|.|..|.|..|....|       ..|:.:..:..||     .:
  Fly   957 AKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKHRC-------NDPICDTHLWKVK-----HE 1009

Human   876 VAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCHFSSLKPSPDL 921
            :..||..:||:...:.:|.:.:.....|::..:..| ..||..|.|
  Fly  1010 LDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNH-HHLKERPPL 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRIK5XP_011525167.1 PBP1_iGluR_Kainate_KA1_2 25..399 CDD:107389 85/437 (19%)
ANF_receptor 42..379 CDD:279440 74/384 (19%)
Periplasmic_Binding_Protein_Type_2 414..785 CDD:304360 118/425 (28%)
Lig_chan 546..816 CDD:278489 67/288 (23%)
Nmdar2NP_001014714.1 PBP1_iGluR_NMDA_NR2 99..490 CDD:107373 87/443 (20%)
PBP2_iGluR_NMDA_Nr2 502..908 CDD:270436 119/429 (28%)
Lig_chan 665..928 CDD:278489 64/279 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156245
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.