DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GRIK5 and Ir41a

DIOPT Version :9

Sequence 1:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens
Sequence 2:	NP_995744.4	Gene:	Ir41a / 2768714	FlyBaseID:	FBgn0040849	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	103/474 - (21%)
Similarity:	166/474 - (35%)	Gaps:	105/474 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   412 LANKTLVVTTILENPYVMRRPNF------QALSGNERFEGFCVDMLRELAELLRF--RYRLRLVE 468
            |..:.:::......||.:.:.|.      ..:||...|:...:|. .|...:|.|  ::...:..
  Fly   208 LQGREVIIAGFDYPPYTVIKHNMSTNAQDMGVSGESDFKNVYIDG-TETRIVLNFCEQFNCTIQI 271

Human   469 DGL----YGAPEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVH 529
            |..    :|...||.|..|.:|.|||| |||:.:.|.....|....:|.|...:..||:.|....
  Fly   272 DSSAANDWGKVYPNMSGDGALGMLINR-KADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAP 335

Human   530 MGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYT-- 592
            : |...::..|:||...:|..:||...|.:..|.||        |.....|...|...|..:|
  Fly   336 L-RLTSWYLPLEPFKETLWAAILLCLCAEATGLVLA--------YKSEQALYVLPGYREGWWTCT 391

Human   593 -LGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESA 656
             .|....|.:  |:.|.......:|:.|.:....:...|||.|.|...||:.||:..|:   |:|
  Fly   392 SFGVCTTFKL--FISQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMD---EAA 451

Human   657 DDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAF- 720
            |                 |:|     |.:.::..|........|....|.|..:..:|.:.:.:
  Fly   452 D-----------------TVT-----RLRFHRLQWAANSEAWVSAIRASDEALVKDILYNFHIYS 494

Human   721 ---LLESTMNEYHRRLNCNLTQIGGLLDTKGYG---IGMPLGSPFRDEITLAILQLQENNRLEIL 779
               ||....:::.|        ||..::...:|   ||..||....|::.:....:.....:..:
  Fly   495 DDELLRLAQDQHMR--------IGFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFV 551

Human   780 KRKW------------WEGGRCPKEEDHRAKG-------------------------LGMENIGG 807
            .|.|            |......|..::|...                         |||.|..|
  Fly   552 PRLWPLLDKLNTLIYSWHSSGFDKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAG 616

Human   808 IFIVLICGLIIAVFVAVME 826
            ..||.|.|..||....::|
  Fly   617 FIIVWILGSAIATLTFLLE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389
		ANF_receptor	42..379	CDD:279440
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	87/404 (22%)
		Lig_chan	546..816	CDD:278489	63/316 (20%)
Ir41a	NP_995744.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156217
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840