DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GRIK4 and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	860	Identity:	345/860 - (40%)
Similarity:	517/860 - (60%)	Gaps:	55/860 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     5 SAPLVLLPAWLVMVACS-------PHSLRIAAIL---DDPMECSRGERLSITLAKNRINRAPERL 59
            |:.:::||..|:.:..:       |..::|..:.   ||..|      |:...|.:|||.....|
  Fly     3 SSGVLVLPLLLLQLILNCRKAQSLPDIIKIGGLFHPADDHQE------LAFRQAVDRINADRSIL 61

Human    60 GKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPE 124
            .::|:...|..:.....:...:.:|.:|..||.|:.||.||..:|. :.:||...|:||.    |
  Fly    62 PRSKLVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASH-VQSICDNMEIPHL----E 121

Human   125 EFVKFQFQRFTTL-NLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDT 188
            ....::.:|.:.| ||:|....:|.|...|:..:...|..:|....:.::.|::||:...::...
  Fly   122 NRWDYRLRRESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKAHGMTPFP 186

Human   189 LSVRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQ 253
            ::||.|.|:.|..||||:|::...|.|::..:....|.:|.:|.::||:|.|::|:.|:|:....
  Fly   187 ITVRQLSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTV 251

Human   254 RMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDH------VPFTGPALSSALLFDAV 312
            .:|.......||.||.:.|      ::....:.:.|  :.|.      ...|.....:||::|||
  Fly   252 NLDEFRYGGTNITGFRLIN------EKIVSDVVRQW--SIDEKGLLRSANLTTVRSETALMYDAV 308

Human   313 YAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALK 377
            :....|:.:|:.||:|.:.|:||.....||||.||:||:::||::|||..|:|:.:|.|:::.|.
  Fly   309 HLFAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLD 373

Human   378 ILQFTRNGFRQIGQWH--VAEGLSMDSHLYA---SNISDTLFNTTLVVTTILENPYLMLKGNHQE 437
            |::.|..|.|:||.|:  :.:|::. :..::   ..|...|.|.||||||||.|||.|.|.:...
  Fly   374 IVELTPAGIRKIGTWNSTLPDGINF-TRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIP 437

Human   438 MEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVGELIARKADLAVAGL 501
            :.|||::||:.||::.|:::.|.|||||:||.||.|| :.:..|.|.||:.||:.::||||:|.|
  Fly   438 LSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADL 502

Human   502 TITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVA 566
            |||.|||:.:||:.|||.||:|||||..:.:.|..||||.|.|..||::|..|||.||.:||::|
  Fly   503 TITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILA 567

Human   567 RLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLI 631
            :.||||| ..:..|.|  ..:.:|::|.|.:||.:|..||||....|:|||||.|:|:||.||||
  Fly   568 KFTPYEW-PAYTDAHG--EKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLI 629

Human   632 IISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYS 696
            :||||||||||||||:|||.||||.:|||.||.|:||.:.|||:..||::|:..||||||::|.|
  Fly   630 MISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMES 694

Human   697 KQPSVFVKSTEEGIARVL--NSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVF 759
            .:||||..|..||:.||.  ..:||||:|||..||..:|||.|||:||:||||.|||..|..|.:
  Fly   695 ARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPY 759

Human   760 RDEFDLAILQLQENNRLEILKRKWWE----GGKCPKE---EDHRAKGLGMENIGGIFVVLICGLI 817
            |...:..||:|||..:|.|||.|||:    ||||..|   ....|..||:.|:||:||||:.|:.
  Fly   760 RTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMG 824

Human   818 VAIFMAMLEFLWTLR 832
            ||..:|:.||:|..|
  Fly   825 VACVIAVCEFVWKSR 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	111/385 (29%)
		ANF_receptor	43..382	CDD:279440	100/345 (29%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	203/372 (55%)
		Lig_chan	547..816	CDD:278489	148/277 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	111/384 (29%)
		ANF_receptor	42..378	CDD:279440	101/354 (29%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	203/372 (55%)
		Lig_chan	547..823	CDD:278489	148/278 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830