DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIK4 and GluRIIC

DIOPT Version :9

Sequence 1:NP_001269399.1 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens
Sequence 2:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster


Alignment Length:967 Identity:259/967 - (26%)
Similarity:431/967 - (44%) Gaps:110/967 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     8 LVLLPAWLVMVACSPHSLRI---AAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIF 69
            |:|...|.....|.....:|   |...||.:|..: |.:::.   |.|| .||    ::..:..:
  Fly     6 LLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEK-EFMTVV---NAIN-GPE----SEQTMRFY 61

Human    70 ELLR-----DSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFV 127
            .|::     |......|..|.::..||.|:.||||. |:|.|::.:|....:||  |.::.|...
  Fly    62 PLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSK-AASDIVALVCNSTGIPHIEFDISDEGIQ 125

Human   128 KFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLI--CAKAECLLNLEKLLRQFLISKDTLS 190
            ..:.....||||:|:...:|.|.|.|:..|......::  ...|.....|:.||:...:..|.:.
  Fly   126 AEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVR 190

Human   191 VRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRM 255
            ||......|...:.|.||.::  .:::....:|...:|..:.|.|:...|.....||||.....:
  Fly   191 VRKFHKDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHL 253

Human   256 DSLVDDR----VNILGFSIF-NQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAV 315
            :.|..|.    |||....:. |.....:     ||...:....|::.:........|:.|.::..
  Fly   254 EELAADNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDLIHDA 313

Human   316 VTAVQELNRS------QEIGVKPLSCGSA----QIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQ 370
            :....:..|:      ..:.|..::|..|    :.|..|    .||..: ::|.:|       ..
  Fly   314 LQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMG----RYLARL-MKGTSG-------VN 366

Human   371 RSNYALKILQFTRNGFR---QIGQWHVAEGLSM-----DSHLYASNISDTLFNTTLV--VTTILE 425
            .:|:...||||..:|.|   .|..:...:|:.:     ...:...|: |......::  |.|.:.
  Fly   367 NTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQITQLNV-DVKAQKKMIYRVATRIG 430

Human   426 NPYLMLKGNHQEME--GNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVG 487
            .||.......:|:.  ||..|:|:.||::..:|..:.|.|....|.|..|| :.:....|.|::|
  Fly   431 PPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIG 495

Human   488 ELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISIL-YR-VHMGRKPGYFSFLDPFSPGVWLF 550
            |:|...|.:.:..||||..|:..:||:.|||.||:||| |: .|:.:.  ..::|.||...||::
  Fly   496 EIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYLAPFGGEVWIW 558

Human   551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRA 615
            :|::...::.:..:|||::..:|.:||||.:.. .:|.||:.:.|:.|..|...|..|..|.||:
  Fly   559 ILISVFVMTFLKTIVARISKMDWENPHPCNRDP-EVLENQWRIHNTGWLTVASIMTAGCDILPRS 622

Human   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQ 680
            ...|.....||.|.:||.:|||||||||||..:|:..|.::.||:.|..:::|||:|||:.....
  Fly   623 PQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLA 687

Human   681 NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQRNCNLTQIGGL 743
            :|....|:..:|.|.:..||.:.|...||:.||..:  :|.||:|:|..||:|::||:|..:|..
  Fly   688 DSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEK 752

Human   744 LDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE--GGKCPKEEDHRA-KGLGMENI 805
            ...|.|.|.:|.|:.:|....:|||:|.|...|..||:|||:  ...|.:|.|..| ..:..|.:
  Fly   753 FGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEEL 817

Human   806 GGIFVVLICGLIVAIFMAMLEFL----------------------------WTLRHSEATEVSVC 842
            .|||..|..|:::|..:.:.|||                            |..|........:.
  Fly   818 RGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPIS 882

Human   843 QEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPD 899
            ....|..||:....|......||..:......:.|..:..|:::.||.  .|.||.:
  Fly   883 SVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNN--AGRGEKE 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GRIK4NP_001269399.1 PBP1_iGluR_Kainate_KA1_2 26..400 CDD:107389 90/403 (22%)
ANF_receptor 43..382 CDD:279440 79/362 (22%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 133/378 (35%)
Lig_chan 547..816 CDD:278489 99/273 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
GluRIICNP_608557.4 PBP1_iGluR_Kainate 26..404 CDD:107377 89/406 (22%)
Periplasmic_Binding_Protein_Type_1 <279..363 CDD:299141 14/93 (15%)
PBP2_iGluR_Kainate 423..794 CDD:270432 133/373 (36%)
Lig_chan 554..828 CDD:278489 99/274 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155757
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60082
OrthoDB 1 1.010 - - D60688at33208
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.960

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