Protein Alignment GRIK4 and Ir8a

DIOPT Version :10

• Sequence 1: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Sequence 2: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Alignment Length: 821
• Identity: 204/821 - (24%)
• Similarity: 342/821 - (41%)
• Gaps: 172/821 - (20%)

Human   179 LRQFLISKDTLSVRMLDDTRDP-TPLLKEIRDDKTAT--IIIHANASMSHTILLKA--AELGMVS 238
            ::|.|:.....::.|.....|| ...|:.||..:.|.  |.:.|.|:..:.|..|.  |:|....
  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRP 211

Human   239 AYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHVPF----- 298
            ..:.::|.:..           |||    |....|:     |.......:.:..|..:|.
  Fly   212 LEWHFVFLDTR-----------DRV----FKYRRQA-----ELCTRFTLNPRAICRSMPMPDLYC 256

Human   299 -TGPALSSALLFDAVYAVVTAV-----------QELN---RSQEIGVKPLSCGSAQIWQHGTSLM 348
             :|..:..|:|.:.:.:::.|.           |:.|   .|.|:. .||....          .
  Fly   257 GSGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVS-DPLEKDD----------Y 310

Human   349 NYLRMVELEGLTG------HI--EFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLY 405
            |:|.||.......      ||  :|.|......:|:.|         ..|.:........|...:
  Fly   311 NWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNI---------SAGYYSSEHEAKTDLAAW 366

Human   406 ASNISDTLFNTTLV-------VTTILENPYLMLKGNH------QEMEGNDRYEGFCVDMLKELAE 457
            :|.....|.|.|:.       :.|....|:..|:...      ::..|...:||:|:|.:..|::
  Fly   367 SSVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQ 431

Human   458 ILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFM-TLG 521
            .|.|.::|.....|..|.....|.|.|:||:|:..:.|.|:|.|.:.:|||:||||..|:. ..|
  Fly   432 KLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTG 496

Human   522 ISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYS-----PHPCAQ 581
            |||..|..: |:...|.|:......|||.::.|.:..:.:::.:.:.:||...:     |:.|
  Fly   497 ISIAIRKPV-RRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC-- 558

Human   582 GRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTV 646
                   .:::|..|.||.:..|..||...||:|:|.|.:...:|.|.:::::::||||||||||
  Fly   559 -------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616

Human   647 QRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRY--QTYQRMWNYM--------------- 694
            :||..|::|::.||.|:.|.|..:....:..:|.|.::  .|..|||..:
  Fly   617 ERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWD 681

Human   695 --------------YSKQPSVFVKSTEEGIARV---LNSNYAFLLESTMNEYYRQRNCNLTQIGG 742
                          .|.||   |...:||.|.|   .|::|||:.:|...:|...||||||::|.
  Fly   682 YPIKEQYGHILLAINSSQP---VADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGE 743

Human   743 LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGG---KCPKEEDHRAKGLGMEN 804
            :...:.|.:.:..||...||...|||:||::...|.||.|:|...   .||..||.  :|:.:|:
  Fly   744 VFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQ--EGITLES 806

Human   805 IGGIFVVLICGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVP 869
            :||:|:..:.||::|:....:|.|:..:...|.|       :|::|.:   .||.......:..|
  Fly   807 LGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE-------ITQVRPV---NDSSGSGGNSSTAP 861

Human   870 PPR----------PPIPEERRPR--------GTATLSNGKL 892
            |..          |.:..|.:|.        .|||....||
  Fly   862 PTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKL 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	46/255 (18%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	124/422 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889		8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	122/415 (29%)