DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KLF15 and cbt

DIOPT Version :9

Sequence 1:	XP_011511045.1	Gene:	KLF15 / 28999	HGNCID:	14536	Length:	435	Species:	Homo sapiens
Sequence 2:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	104/346 - (30%)
Similarity:	145/346 - (41%)	Gaps:	105/346 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   142 PEFPLGDPDDVPRPFQPTL----------------EEIEEFLEENMEPGVKEVPEGNSKDLDACS 190
            ||..:  |:..||..||.:                |.:...:..|....|    ..:|:|.::.|
  Fly    66 PEIAV--PNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAV----SSSSQDENSSS 124

Human   191 QLSAGPHKSHLHPGSSGRERCSPPPGGASAGGAQGPGGGPTPDGPIP---VLLQIQPVPVKQESG 252
            ..|.....|:.:..:|     |.|               ||.:...|   |...::....::.:.
  Fly   125 STSCCSSSSNTNTSTS-----SVP---------------PTVEDDYPEANVWRNLKFKMNRKRAA 169

Human   253 TGPASPGQAPENVKVAQLLVNIQGQTFALVPQVVPSSNLNLPSKFVR---IAPV--PIAAKPVGS 312
            .....|.|.|| ..||:|              |.|.:    |::.::   |.|:  ||...||.|
  Fly   170 EVALPPVQTPE-TPVAKL--------------VTPPA----PAECIKEEEIKPILTPIYVSPVAS 215

Human   313 ------------GPLGPGPAGLLMGQKFPKNP----------------AAELIKMHKCTFPGCSK 349
                        ....|.|.        ||.|                ||...::::|:||.|.|
  Fly   216 SASQLILLSTVAAQQSPTPV--------PKTPTMSEEKLTTRITAAQAAATRSRIYECSFPDCGK 272

Human   350 MYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDH 414
            .|.||||||||.|.||||:||.|.|..|..|||||||||||:|:|:|.|.:||.||:|||.||||
  Fly   273 NYFKSSHLKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDH 337

Human   415 LSKHIKVHRFPRSSRSVRSVN 435
            ||||:|.|...:::...|.|:
  Fly   338 LSKHVKRHNKDKANGVNRHVS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KLF15	XP_011511045.1	zf-C2H2	340..364	CDD:278523	15/23 (65%)
		zf-C2H2_8	342..421	CDD:292531	54/78 (69%)
		C2H2 Zn finger	342..364	CDD:275368	15/21 (71%)
		zf-H2C2_2	356..383	CDD:290200	17/26 (65%)
		C2H2 Zn finger	372..394	CDD:275368	15/21 (71%)
		zf-H2C2_2	386..411	CDD:290200	16/24 (67%)
		C2H2 Zn finger	402..422	CDD:275368	15/19 (79%)
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	15/23 (65%)
		C2H2 Zn finger	265..287	CDD:275368	15/21 (71%)
		COG5048	<270..362	CDD:227381	55/89 (62%)
		zf-H2C2_2	279..306	CDD:290200	17/26 (65%)
		C2H2 Zn finger	295..317	CDD:275368	15/21 (71%)
		zf-H2C2_2	309..332	CDD:290200	14/22 (64%)
		zf-C2H2	323..345	CDD:278523	16/21 (76%)
		C2H2 Zn finger	325..345	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940