Protein Alignment HIPK2 and YAK1

DIOPT Version :9

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_012394.1
• Gene: YAK1 / 853300
• SGDID: S000003677
• Length: 807
• Species: Saccharomyces cerevisiae
• Alignment Length: 659
• Identity: 199/659 - (30%)
• Similarity: 306/659 - (46%)
• Gaps: 105/659 - (15%)

Human   192 QVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKV--YSQSKNIPLSQPATTTVSTSLPVPN 254
            ||:....:..|.|.|    :..||. :|...:.....:  .:.|.|.......|...:.|:||.:
Yeast   175 QVYQQGAIHPSQFGS----RFVPSL-YDRQDFQRRQSLAATNYSSNFSSLNSNTNQGTNSIPVMS 234

Human   255 PSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVS----LLDTYQKCGLKRKSE 315
               ||.:...:|.|              |...|..|...:||..|.    .:...|.|..|...:
Yeast   235 ---PYRRLSAYPPS--------------TSPPLQPPFKQLRRDEVQGQKLSIPQMQLCNSKNDLQ 282

Human   316 EIENTSSVQIIEEHPPMIQNNASGATVATATTST----------------ATSK----------- 353
            .:.|.:        |...:.:.:..|::...:.|                .|||
Yeast   283 PVLNAT--------PKFRRASLNSKTISPLVSVTKSLITTYSLCSPEFTYQTSKNPKRVLTKPSE 339

Human   354 ---NSG-SNSEGDYQLVQHEVL-CSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 413
               |:| .|...||.|..::|| ......|.||:.||:|||||||||....|.||:|:|::|:..
Yeast   340 GKCNNGFDNINSDYILYVNDVLGVEQNRKYLVLDILGQGTFGQVVKCQNLLTKEILAVKVVKSRT 404

Human   414 SYARQGQIEVSILARLS--TESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLP 476
            .|..|...|..||..|:  .:..:.::|:|.|:.|.||||.|||||:|..|||:.||||||..|.
Yeast   405 EYLTQSITEAKILELLNQKIDPTNKHHFLRMYDSFVHKNHLCLVFELLSNNLYELLKQNKFHGLS 469

Human   477 LKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYL 541
            ::.||....|:..:|..||...|||.|||||||:|..|.:.  .:|:|||||:...::.| .||:
Yeast   470 IQLIRTFTTQILDSLCVLKESKLIHCDLKPENILLCAPDKP--ELKIIDFGSSCEEARTV-YTYI 531

Human   542 QSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSA 606
            |||:|||||||||:|:..:||||||||::||||||.|::||||||:|:..|..|.|.|..:::..
Yeast   532 QSRFYRAPEIILGIPYSTSIDMWSLGCIVAELFLGIPIFPGASEYNQLTRIIDTLGYPPSWMIDM 596

Human   607 GTKTTRFFNR----DTDSPYPLWRLKTPDDHEAETGIKSKEARKYI-FNCLDDMAQ-VNMTTDLE 665
            |..:.:|..:    ::.|.....|:||.::...|..|..|.:::|. :..|.|:.: ......::
Yeast   597 GKNSGKFMKKLAPEESSSSTQKHRMKTIEEFCREYNIVEKPSKQYFKWRKLPDIIRNYRYPKSIQ 661

Human   666 GSDMLV--EKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLD--FPHSTHVKSCFQN 726
            .|..|:  |..:|...|..|..:|.::..:|.||.:.:.|||:|......  ||..:.:....:.
Yeast   662 NSQELIDQEMQNRECLIHFLGGVLNLNPLERWTPQQAMLHPFITKQEFTGEWFPPGSSLPGPSEK 726

Human   727 MEICKRRVNMYDTVNQSKT----PFITHVAPSTST----------------NLTMTFNNQLTTVH 771
            .:..|.:.:.|.:.|.|..    .::.:  ||::|                |.:...:|.....|
Yeast   727 HDDAKGQQSEYGSANDSSNNAGHNYVYN--PSSATGGADSVDIGAISKRKENTSGDISNNFAVTH 789

Human   772 NQAPSSTSA 780
            :.....|||
Yeast   790 SVQEGPTSA 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	148/366 (40%)
		S_TKc	378..706	CDD:214567	140/337 (42%)
YAK1	NP_012394.1	PKc_YAK1	369..704	CDD:271114	140/337 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I367
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940