Protein Alignment HIPK2 and hipk2

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: XP_005159048.2
• Gene: hipk2 / 557551
• ZFINID: ZDB-GENE-031125-4
• Length: 1230
• Species: Danio rerio
• Alignment Length: 1234
• Identity: 978/1234 - (79%)
• Similarity: 1050/1234 - (85%)
• Gaps: 52/1234 - (4%)

Human   186 GMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSL 250
            ||||.||||||||||||||.||||||:|.|.||||||||:|||||||:....:|.........||
Zfish     7 GMASQVQVFSPHTLQSSAFFSVKKLKVEQSCNWDMTGYGTHSKVYSQNSKQSVSVAPVGINGASL 71

Human   251 PVPNPSLPYEQTIVFPGSTGHIVVTSASSTS-VTGQVLG---------GPHNLMRRSTVSLLDTY 305
            .|.|.||.|||.::||..:|||||.|||||| ..||:||         |.|||.|||||||||||
Zfish    72 QVSNSSLSYEQALLFPAGSGHIVVASASSTSGAAGQLLGSTGSSGSGSGGHNLTRRSTVSLLDTY 136

Human   306 QKCGLKRKSEEIENT------SSVQIIEEH---PPMIQNNA-SGATVATATTS-TATSKNSGSNS 359
            |:|||||||||::|.      |||.::||.   .||||||. |||||||||.| ||||||||:||
Zfish   137 QRCGLKRKSEELDNNNGSGSGSSVHVVEEQQPPAPMIQNNVQSGATVATATASTTATSKNSGANS 201

Human   360 EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVS 424
            ||||||:||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Zfish   202 EGDYQLLQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVS 266

Human   425 ILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVAT 489
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
Zfish   267 ILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVAT 331

Human   490 ALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 554
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Zfish   332 ALMKLKSLGLIHADLKPENIMLVDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILG 396

Human   555 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTD 619
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Zfish   397 LPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPD 461

Human   620 SPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLK 684
            |.|||||||||:|||||||||||||||||||||||||||||||||||||||.||||||||||||.
Zfish   462 STYPLWRLKTPEDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLAEKADRREFIDLLT 526

Human   685 KMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFIT 749
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   527 KMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFIT 591

Human   750 HVAPSTSTNLTMTFNNQLTTVHNQ----APSSTSATISLANPEVSILNYPSTLYQPSAASMAAVA 810
            ||||||||||||||||||.|||:|    ||||||||:||.||:||||||.|.|||||||.|||||
Zfish   592 HVAPSTSTNLTMTFNNQLNTVHSQATNLAPSSTSATLSLTNPDVSILNYQSALYQPSAAPMAAVA 656

Human   811 QRSMPLQTGTAQIC-ARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPL 874
            .|:||||.|..|:| |||||||||||||||||||||||||||.||||||||||||||||||||||
Zfish   657 PRTMPLQPGAPQLCAARPDPFQQALIVCPPGFQGLQASPSKHTGYSVRMENAVPIVTQAPGAQPL 721

Human   875 QIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSH 939
            |||||||.||||||||||||||||||||    ||||||||||||::|..:|.||:|||:|.||||
Zfish   722 QIQPGLLTQQAWPSGTQQILLPPAWQQL----THTSVQHATVIPDSMTSSQPLANWRNSHPHGSH 782

Human   940 YNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAI 1004
            |||||||||||.||||||..|||||||||||||...:.::|:|:||||.:.||:|..:|||:|.:
Zfish   783 YNPIMQQPALLAGHVTLPPQQPLNVGVAHVMRQPSNNQSNSKKNKQHQMNNRNMSAYDVSSTQPV 847

Human  1005 SSPQRSKRVKENTPPRCAMVHSSP--ACSTSVTC---GW-GDVASSTTRERQ------RQTIVIP 1057
            :|||||||||||||||||:|.:.|  .|..|.||   || |:.|.||||:..      ||||:||
Zfish   848 TSPQRSKRVKENTPPRCAVVQNGPPSTCVPSQTCTGGGWGGEQACSTTRDHHGQHNPPRQTIIIP 912

Human  1058 DTPSPTVSVITISSDTDEEEEQKH-APTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRA 1121
            |||||.||:||||||||||::.|. ..|||.|||||||||||||||||.|| |||||||:|..|.
Zfish   913 DTPSPAVSIITISSDTDEEDDLKQPTNTSTSSKQRKNVISCVTVHDSPDSD-SSNTSPYAVDSRT 976

Human  1122 GHNNANAFDTKGS-LENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNV 1185
            ...|||.:|:||: |:|:..|||||||:||||:|.||.|.|||.|:|...:|.:|:||.|:|:..
Zfish   977 NGPNANGYDSKGAVLDNYSNGNPRTIIIPPLKSQTSENLGECDRLLPDVMNHQNSTYKFKTSNGG 1041

Human  1186 TSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMA-QAP 1249
            .|.:.|:||..:|...|||||.|||..|||||||||||||:..:|.|.||||||||||||| ||.
Zfish  1042 FSGNNHTSGGVTGGGAYRQQRTGPHPFQQQPLNLSQAQQHMAVERNGGHRRQQAYITPTMATQAQ 1106

Human  1250 YSFPHNSPSH-GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHT 1313
            ||| ||||:| ..|||||    ||.|||.|||||||||||||||||||||||||||||||.|||.
Zfish  1107 YSF-HNSPTHTANVHPHL----AAPHLPGQPHLYTYTAPAALGSTGTVAHLVASQGSARHAVQHA 1166

Human  1314 AYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI 1377
            :||..||||||||||.|||||||:|..||.|||||||||||||||||||||||||.|:|||||:
Zfish  1167 SYPPGIVHQVPVSMGHRVLPSPTLHHGQYQAQFAHQTYISASPASTVYTGYPLSPTKMNQYPYL 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	344/353 (97%)
hipk2	XP_005159048.2	None