Protein Alignment HIPK2 and Dyrk3

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Alignment Length: 841
• Identity: 220/841 - (26%)
• Similarity: 348/841 - (41%)
• Gaps: 208/841 - (24%)

Human   156 GLQEATLENKC-QVLKRLNIE------SPPDLAVPLPGMASHVQVFS----PHTLQSSAFCSVKK 209
            |||..|   :| :.|..||..      .|.:.....||....:.:|.    ..::|:.:..:|
  Fly    79 GLQYLT---RCFEPLAMLNDSKEDFPTQPSNNIANYPGDIQILPIFDCCEISESIQAISLPNV-- 138

Human   210 LKIEPSSNWDMTGYGSHS-KVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIV 273
              ..||...|:.|....: ...|:||:.|..:...:...:|:...:..|.:||.|
  Fly   139 --TSPSKTKDVPGLFLRTISENSKSKSEPECESLISVKESSVMENHTFLFHEQII---------- 191

Human   274 VTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMI--QNN 336
                    ::||                    |||.|..|.:       |.::.....||  .|.
  Fly   192 --------MSGQ--------------------QKCELHEKPK-------VLVVSPQQVMILYMNK 221

Human   337 AS----------------GATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLG 385
            .:                ||...........:.:...|.:|.|..|.|:   .:...||:|:.:|
  Fly   222 LTPYERTEILTYPQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRYEMLKIIG 283

Human   386 RGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDY---NFVRAYECFQ 447
            :|:||||:|.:...|:|.||:||::|...:.||.|.|:.||..|...  |.|   |.:..::.|.
  Fly   284 KGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRH--DKYNTMNIIHMFDYFT 346

Human   448 HKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLV 512
            .:||||:.||:|..|||:.:|:|.|....|:.:|.....:...|..|....:||.|:||||::|.
  Fly   347 FRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLK 411

Human   513 DPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGW 577
            ...|.  .:|||||||:...::.: .||:|||:|||||:|||..:..|||||||||::|||..|.
  Fly   412 QQGRS--GIKVIDFGSSCFENQRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGH 473

Human   578 PLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSP--YPLW-RLKTPDD------- 632
            .|:||.:|.||:..|.:..|:|.:.:|::..::..||     ||  ||.: .::|..|
  Fly   474 ALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF-----SPKGYPRYCTVRTMSDGMVVLIG 533

Human   633 HEAETGIK-----SKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDAD 692
            .::..|.:     ||...|.:..|.|.:                       |::.::..|..|||
  Fly   534 GQSRRGKQRGPPCSKSLSKALDGCKDPL-----------------------FLNFIRGCLEWDAD 575

Human   693 KRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTST 757
            ||:||.|.|.||:  :...|..|.|:. ..|.....:|..|       |:|         |.|..
  Fly   576 KRLTPSEALKHPW--LRRRLPRPPSSS-SGCGGVSGLCSSR-------NES---------PVTGQ 621

Human   758 NLTMTFNNQLTTVHNQAPSSTSATISLANPEVSI-LNY---PSTLYQ-----PSAASMAAVAQRS 813
            |......   ||..:.:.:|.|.||...|...|: |::   |.|.::     |..:|.|.    .
  Fly   622 NRNFAAE---TTASSTSATSISLTIKRENSHSSLRLHHGAVPETDFKLIKSVPEGSSTAT----K 679

Human   814 MPLQTGTAQICARPDPFQQALIVCPP-------GFQGLQA---SPSKHAGYSVRME--------- 859
            .|:....    ..|:.|:|..:|.|.       |...|.|   .||::..|....|
  Fly   680 EPMMNSD----ILPESFRQTTVVSPSKHSADSGGMSCLSAVDVGPSRYYPYMNNNENNRLFSSSL 740

Human   860 ----NAVPIVTQAP-----GAQPLQIQPGLLAQQ---AWPSGTQQILLPPAWQQLTGVATH 908
                |::..:.||.     |.......|.||::.   ::.||:  |.:..|.:.|..:|::
  Fly   741 NSSANSLSHLEQATKLDALGEYSASTTPNLLSKNTGYSFNSGS--INIDVAQESLVNIASN 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	128/371 (35%)
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	134/415 (32%)