Protein Alignment HIPK2 and Hipk

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Alignment Length: 1462
• Identity: 515/1462 - (35%)
• Similarity: 672/1462 - (45%)
• Gaps: 455/1462 - (31%)

Human   202 SAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFP 266
            |.|||               |.|:...|.:.|.....:..|||..:.........|..:|
  Fly    23 SGFCS---------------GLGAGLSVRATSFYGDQTVTATTDGTRHQEQQQQQLQQQQ----- 67

Human   267 GSTGHIVVTSASSTSVTGQVLGGPHNLMRRST---VSLLDTYQKCGLKRKSEEIENTSSVQIIEE 328
              ..||:...|:|.| |..|.....:..:|.|   ...:|:|             |:|
  Fly    68 --QQHILRQPATSAS-TSSVAAAATSKRKRQTDCDCGCVDSY-------------NSS------- 109

Human   329 HPPMIQNNASGA-----------------------TVATATTSTAT----------SKNSGSNSE 360
            |.|.:|.::|.|                       ::.||.|..||          ||.|.|.::
  Fly   110 HGPPVQQDSSAAAGAGSVGSKAGSGPGPDGIGPISSLKTAHTKVATSGGHANTQPPSKRSSSGAD 174

Human   361 GDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSI 425
            |||||||||||.|::..|||||||||||||||||||||||:||||||||||||||||||||||||
  Fly   175 GDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIEVSI 239

Human   426 LARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATA 490
            |:|||.|:||::|||||:|||||||||||||||||||||||||||||||||||||||:|:||.||
  Fly   240 LSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTA 304

Human   491 LMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGL 555
            |:|||.||||||||||||||||||.|||||||||||||||||||.||:|||||||||||||||||
  Fly   305 LLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCNTYLQSRYYRAPEIILGL 369

Human   556 PFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDS 620
            ||||||||||||||:||||||||||||:||:|||||||||||||.|::|::.:||::||.||.||
  Fly   370 PFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDS 434

Human   621 PYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKK 685
            .||.|||||.::|||||..|||||||||||||||:.|||:.|||||..:|.||.||||||||||:
  Fly   435 TYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKR 499

Human   686 MLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITH 750
            |||||.::|:||.|.|||.|..:|||:|:.:..:||:..|.||:|:|  ..:.||..:.| .:|:
  Fly   500 MLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEVCRR--GDFHTVQPAST-LVTN 561

Human   751 VAPSTSTNLTMTFNNQLTT-----VHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVA 810
            ..||::.|:|.|.|||||:     |.:..|.:......:.|.......||.|
  Fly   562 FVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEGLYQIYNGRSVARQYPQT------------- 613

Human   811 QRSMPLQTGTAQICARPDPFQQAL---IVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQ 872
                           |.|.||..|   |:|||.:|.: .||:||.           :|..|....
  Fly   614 ---------------RTDSFQHQLVSNILCPPSYQTM-PSPTKHV-----------VVGSATMQP 651

Human   873 PLQIQPG--------------------LLAQQ------AWPSGTQQILLPPAWQQLTGVATHTSV 911
            |||:.|.                    ||..:      |||...:|:.|.|:|.|       .:.
  Fly   652 PLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQ-------QAP 709

Human   912 QHATVIPET-MAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPT 975
            .|:.::..| :...:::        :..|             |:.||.........||.:.:..:
  Fly   710 AHSLIVDSTPLFNVEEI--------YPKH-------------HLNLPRNDLKKESPAHHIAKGNS 753

Human   976 STTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP------RCAMVHSSPACSTSV 1034
            ......:.|:||.                .||.: |||||::||      |.|  |.||......
  Fly   754 YRVPRHEKKEHQQ----------------LSPVK-KRVKESSPPHQQRYQRAA--HVSPQYHAHH 799

Human  1035 TCGWGD-----------VASSTT------------------------------------------ 1046
            .|.:|:           ||||..
  Fly   800 NCNYGNGSGYSASAGSVVASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANG 864

Human  1047 -------------------------------RERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ- 1079
                                           :..::.||.|.|||||| :|||||...||..|.
  Fly   865 GAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPT-AVITISDSEDEGGEAG 928

Human  1080 ----------------------KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAG 1122
                                  :|||:|:.|:.        :.|..|:        |:..||:..
  Fly   929 GAQVPVLKQRAHAQSQTSGSLLQHAPSSSCSRS--------SAHQQPH--------PHPQQQQQQ 977

Human  1123 HNNANAFDTKGSLENH------CTGNPR--------TIIVPPLKTQ--------ASEVLVECDSL 1165
            ..|....|.:.:...|      ..|:|:        ....||.:.|        ..:||.:..
  Fly   978 QINYGDHDPEDARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQ-- 1040

Human  1166 VPVNTSHHSSSYKSKSSSNVTSTSGH-----SSGSSSGAITY--RQQRPG---PHFQQQQPLNLS 1220
             |........|.|.:..:...|..|:     |..|||.::.:  .:|.|.   |.:....|..|.
  Fly  1041 -PSIKYEPGQSQKKRILAMAQSECGYQPQVPSQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLD 1104

Human  1221 QAQQHITTDRTGS--------HRRQQA-------YITPTMA-QAPYSFPHNSPSHGTVHPHLAAA 1269
            ..:.......:||        |.:::|       |:.|::| ...:|...::.|..::....|||
  Fly  1105 TKRSSWAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAA 1169

Human  1270 AAAA------------------HLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYP 1316
            ||||                  ..|:||      .|.::|..|:.....:|.....|...|..:.
  Fly  1170 AAAAAAAAASVGPPSWGPPQVYRQPSQP------PPGSVGLPGSTQPPPSSVAPHPHHHSHGHHH 1228

Human  1317 ASIVHQV-------PVSMGPRVLPSPTIH--------PSQYPAQ------FAHQTYISASPA--- 1357
                ||.       |.|.....|..|.|:        |:.:.:|      :|::..::..||
  Fly  1229 ----HQAGTPLGGSPSSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAYANRAVVAPPPAHNS 1289

Human  1358 -----------------STVYTGY-PLSPAKV 1371
                             .|.|:.: |||||:|
  Fly  1290 SSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQV 1321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	290/353 (82%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	274/327 (84%)
		PHA03378	<1080..1327	CDD:223065	50/252 (20%)