Protein Alignment HIPK2 and Dyrk2

DIOPT Version :9

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 810
• Identity: 209/810 - (25%)
• Similarity: 343/810 - (42%)
• Gaps: 194/810 - (23%)

Human   222 GYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQV 286
            |.|:.:...:.:.||.....::||.|::......|.....:....||:|:    |||||. :|::
  Fly    97 GNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGN----SASSTG-SGEL 156

Human   287 LGG----PHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATT 347
            ...    |..|:::....|.|.        :.||::....|....:|.....|..:
  Fly   157 KCNTPMTPSELVKKFRNYLTDL--------EFEELKVYKEVWYFGQHASKNYNKPA--------- 204

Human   348 STATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 411
            .||.:.|.| .:..|:|::::|:   .:...||:||.:|:|:||||::.....||..|||||::|
  Fly   205 PTANTTNLGYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRN 266

Human   412 HPSYARQGQIEVSILARLSTESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPL 475
            ...:..|..:|::||..|..:.|| .:|.:...:....:.|.|:.||::..|||:.:|:|.::..
  Fly   267 KKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGF 331

Human   476 PLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTY 540
            .:..||.....:...|..|....:||.|||||||:|  ..|....:|||||||:.:|.:.: .||
  Fly   332 SMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL--KQRGSSSIKVIDFGSSCYVDRKI-YTY 393

Human   541 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLS 605
            :|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|||.:.|:|
  Fly   394 IQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLIS 458

Human   606 AGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARK---------YIFNCLDDMAQVNMT 661
            ...:...||                |..:|...|.:.:.||         :|.:|.|
  Fly   459 VARRRRLFF----------------DSRDAPRCITNTKGRKRSPGSKSLAHILHCQD-------- 499

Human   662 TDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQN 726
                           |.|||.|::.|..|..:|:||.|..:|.|      |....|:..:||..:
  Fly   500 ---------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF------LQPSASSRHRSCRMS 543

Human   727 MEICKRRVNMYDTVNQSKTPF-ITHVAPSTS----TNLTMTFNNQLTTVHN----------QAPS 776
            .......:|   :|:|..:.: .:.::|.|:    .::|.|     |.|||          |.|.
  Fly   544 SSSSSSGLN---SVSQKSSCYSFSEISPGTNGPVVASITST-----TAVHNAAIATTTKSRQQPP 600

Human   777 STSATISLAN---PEVSILNYPSTLYQPSAA----SMAAVAQRSMPLQTGTAQICARPDPFQQAL 834
            |.|...:.:|   |::.:          ||:    ||..||.||..    |:.:.......|.:|
  Fly   601 SQSHGHAQSNGHLPDIKL----------SASDKYNSMQKVAVRSKI----TSSVSDLESVQQYSL 651

Human   835 IVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW 899
            ...   :.|:.:..:.|...:...::       .||.     ..|::...:...|:.
  Fly   652 HRI---YGGVGSGSTHHVSSAATRKH-------LPGT-----GSGIVGAMSSKYGSS-------- 693

Human   900 QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNV 964
               |....|.:|.|......|:|.|        ||.|..|..
  Fly   694 ---TLAHNHHNVTHHNASTATIATT--------THHHHHHGG----------------------- 724

Human   965 GVAHVMRQQPTSTTSSRKSKQHQSSVRNVS 994
                 .:||.:|:.:|..:..|..|..:||
  Fly   725 -----QQQQQSSSGASTMAMSHSQSTGDVS 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	122/363 (34%)
		S_TKc	378..706	CDD:214567	118/337 (35%)
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	129/402 (32%)
		S_TKc	233..529	CDD:214567	119/343 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840