Protein Alignment HIPK2 and Dyrk2

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 806
• Identity: 209/806 - (25%)
• Similarity: 342/806 - (42%)
• Gaps: 186/806 - (23%)

Human   222 GYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQV 286
            |.|:.:...:.:.||.....::||.|::......|.....:....||:|:    |||||. :|::
  Fly    97 GNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGN----SASSTG-SGEL 156

Human   287 LGG----PHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATT 347
            ...    |..|:::....|.|.        :.||::....|....:|.....|..:
  Fly   157 KCNTPMTPSELVKKFRNYLTDL--------EFEELKVYKEVWYFGQHASKNYNKPA--------- 204

Human   348 STATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 411
            .||.:.|.| .:..|:|::::|:   .:...||:||.:|:|:||||::.....||..|||||::|
  Fly   205 PTANTTNLGYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRN 266

Human   412 HPSYARQGQIEVSILARLSTESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPL 475
            ...:..|..:|::||..|..:.|| .:|.:...:....:.|.|:.||::..|||:.:|:|.::..
  Fly   267 KKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGF 331

Human   476 PLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTY 540
            .:..||.....:...|..|....:||.|||||||:|  ..|....:|||||||:.:|.:.: .||
  Fly   332 SMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL--KQRGSSSIKVIDFGSSCYVDRKI-YTY 393

Human   541 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLS 605
            :|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|||.:.|:|
  Fly   394 IQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLIS 458

Human   606 AGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARK---------YIFNCLDDMAQVNMT 661
            ...:...||                |..:|...|.:.:.||         :|.:|.|
  Fly   459 VARRRRLFF----------------DSRDAPRCITNTKGRKRSPGSKSLAHILHCQD-------- 499

Human   662 TDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQN 726
                           |.|||.|::.|..|..:|:||.|..:|.|      |....|:..:||..:
  Fly   500 ---------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF------LQPSASSRHRSCRMS 543

Human   727 MEICKRRVNMYDTVNQSKTPF-ITHVAPSTS----TNLTMTFNNQLTTVHN----------QAPS 776
            .......:|   :|:|..:.: .:.::|.|:    .::|.|     |.|||          |.|.
  Fly   544 SSSSSSGLN---SVSQKSSCYSFSEISPGTNGPVVASITST-----TAVHNAAIATTTKSRQQPP 600

Human   777 STSATISLAN---PEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCP 838
            |.|...:.:|   |::.:  ..|..|.    ||..||.||..    |:.:.......|.:|...
  Fly   601 SQSHGHAQSNGHLPDIKL--SASDKYN----SMQKVAVRSKI----TSSVSDLESVQQYSLHRI- 654

Human   839 PGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLT 903
              :.|:.:..:.|...:...::       .||.     ..|::...:...|:.           |
  Fly   655 --YGGVGSGSTHHVSSAATRKH-------LPGT-----GSGIVGAMSSKYGSS-----------T 694

Human   904 GVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAH 968
            ....|.:|.|......|:|.|        ||.|..|..
  Fly   695 LAHNHHNVTHHNASTATIATT--------THHHHHHGG--------------------------- 724

Human   969 VMRQQPTSTTSSRKSKQHQSSVRNVS 994
             .:||.:|:.:|..:..|..|..:||
  Fly   725 -QQQQQSSSGASTMAMSHSQSTGDVS 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	122/363 (34%)
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	129/402 (32%)