Protein Alignment HIPK2 and mnb

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Alignment Length: 1106
• Identity: 250/1106 - (22%)
• Similarity: 400/1106 - (36%)
• Gaps: 328/1106 - (29%)

Human   206 SVKKLKIEPSSNWDMTGYGS-------------------HSKVYSQSKNIPLSQPATTTVSTSLP 251
            |..::|.|.:..:.|:.|||                   |:.:|.:..:           :..||
  Fly   145 SSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVD-----------AEDLP 198

Human   252 VPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCG------L 310
            ..:..:.:..:  .|.|:..:....|...:...:...||   :|:.:|.|:.||:...      .
  Fly   199 ATHRDVMHHHS--SPSSSSEVRAMQARIPNHFREPASGP---LRKLSVDLIKTYKHINEVYYAKK 258

Human   311 KRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEG-DYQLVQHEVLCSM 374
            ||::::.:....                     ::........|.|.:.:. ||.:...|   ..
  Fly   259 KRRAQQTQGDDD---------------------SSNKKERKLYNDGYDDDNHDYIIKNGE---KF 299

Human   375 TNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADD-YN 438
            .:.||:...:|:|:||||||.:.......|||||:||...:..|.||||.:|..::...|:: |.
  Fly   300 LDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYY 364

Human   439 FVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS--LGLIH 501
            .|:....|..:||.|||||:|..||||.|:...|..:.|...|...||:.|||:.|.:  |.:||
  Fly   365 IVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIH 429

Human   502 ADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSL 566
            .|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::||:.:..|||||||
  Fly   430 CDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVLLGIQYDLAIDMWSL 491

Human   567 GCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR-DTDSPYPLWRLKTP 630
            ||::.|:..|.||:.|.:|.||:..|.:..|:|.:|||....||.:||:: ..|..|.|
  Fly   492 GCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDKIVADGSYVL------ 550

Human   631 DDHEAETGIKSKEARKYI---FNCLDDMAQVNMTTDLEGSDMLVEK----ADRREFIDLLKKMLT 688
                    .|::..|||.   ...|.|:  :.:.|...|...|.|.    :|..:|.||:.:||.
  Fly   551 --------KKNQNGRKYKPPGSRKLHDI--LGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLD 605

Human   689 IDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAP 753
            .|...|:||...|.|.|.                        ||
  Fly   606 FDPKTRVTPYYALQHNFF------------------------KR--------------------- 625

Human   754 STSTNLTMTFNNQLTTVHNQAPSSTSAT-----------ISLANPEVSILNYPSTLYQPSAASMA 807
             |:...|.|.....|.......|.:|..           :..:|.....:: .|:...|:||:.|
  Fly   626 -TADEATNTSGAGATANAGAGGSGSSGAGGSSGGGVGGGLGASNSSSGAVS-SSSAAAPTAATAA 688

Human   808 AVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYS--VRMENAVPIVTQAPG 870
            |.|                               .|...|.|...|.|  .:.:.|:|:    |.
  Fly   689 ATA-------------------------------AGSSGSGSSVGGGSSAAQQQQAMPL----PL 718

Human   871 AQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHA 935
            ..||.:.|     .|.|.|...       .|..|:..|      :|....|.....|:...|.|
  Fly   719 PLPLPLPP-----LAGPGGASD-------GQCHGLLMH------SVAANAMNNFSALSLQSNAH- 764

Human   936 HGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVM--------RQQPTSTTSSRKSKQHQSSVRN 992
                     ..|:|...|.:..:...||    |:.        ....:|..::|.|:.:.|::.|
  Fly   765 ---------PPPSLANSHHSTNSLGSLN----HISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVN 816

Human   993 V----STCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQT 1053
            :    ::...::..:||.|...:......||.....|.                      |.|..
  Fly   817 MVGHHNSGSSNNHNSISYPHAMECDPPQMPPPPPNGHG----------------------RMRVP 859

Human  1054 IVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQ 1118
            .::...|:                  .:||.|.                 ||..:.|::|..:..
  Fly   860 AIMQLQPN------------------SYAPNSV-----------------PYYGNMSSSSVAAAA 889

Human  1119 QRAGHNNANAFDTKGSL----------------ENHCTGNPRTIIVP--PLKTQASEVLVECDSL 1165
            ..|....::...|..|:                :|..|.:....:.|  |..|.....|.....|
  Fly   890 AAAAAAASHLMMTDSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDL 954

Human  1166 ---------VPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQ 1221
                     ||:.....|||..|..|::|     .|.|...|.:..|:...||..|    :.:||
  Fly   955 PLPMPLPMSVPLQLPPSSSSSVSSGSASV-----GSGGVGVGVVGQRRHITGPAAQ----VGISQ 1010

Human  1222 A 1222
            :
  Fly  1011 S 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	133/364 (37%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	136/406 (33%)