Protein Alignment HIPK2 and ppk15

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_593830.1
• Gene: ppk15 / 2542228
• PomBaseID: SPAC823.03
• Length: 534
• Species: Schizosaccharomyces pombe
• Alignment Length: 603
• Identity: 196/603 - (32%)
• Similarity: 280/603 - (46%)
• Gaps: 111/603 - (18%)

Human   231 SQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLG------- 288
            |.|..:|||.             ||  |..:|........|....|:|.|::...|..
pombe     3 SDSPILPLSN-------------NP--PAARTHDHSQRNNHARHVSSSGTTLFAPVKPATKKYNY 52

Human   289 ---GPH----NLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHP--PMIQNNASGATVAT 344
               .||    :.:...||.|.|||..|..|.:...          |::|  |:
pombe    53 RRVSPHGSYISPLEAMTVKLADTYSICNPKFQFSS----------EQNPRRPL------------ 95

Human   345 ATTSTATSKNSGSNSEG------DYQLVQHEVL-CSMTNTYEVLEFLGRGTFGQVVKCWKRGTNE 402
                  |..:.|.::.|      ||.|..:::| ......|.:|:.||.||||||.:|....|.:
pombe    96 ------TKPSEGVHNHGFDNVNHDYVLYVNDLLGTDEGRKYLILDTLGHGTFGQVARCQDLKTQQ 154

Human   403 IVAIKILKNHPSYARQGQIEVSILARLST--ESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYD 465
            |||||::||.|::..|..:|||||..|:.  :..|..:.:|.|:.|.||||.|||||:|..|||:
pombe   155 IVAIKVIKNKPAFYNQCVMEVSILELLNNKYDPEDKRHLIRLYDQFMHKNHLCLVFELLSINLYE 219

Human   466 FLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSAS 530
            .:|||:|..|.|..:|....|:.:....||...:||.|||||||:|.|.| .|. |||||||||.
pombe   220 LIKQNQFRGLHLSLVRSFATQLLSCTSLLKQARIIHCDLKPENILLQDLS-SPI-VKVIDFGSAC 282

Human   531 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQT 595
            |..:.| .||:|||:||:||:||||.:...||||||||::||||||.||:||.|||:|:..|...
pombe   283 HERQTV-YTYIQSRFYRSPEVILGLHYNCGIDMWSLGCILAELFLGLPLFPGNSEYNQLCRIVDM 346

Human   596 QGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 660
            .|.|..::|..|..:.:::|....:....:.||:.:....|.....:..::|......|...:|.
pombe   347 LGNPPTWMLEMGKNSKKYYNSGFVNGRKTYELKSIEQFSIENNKTEQPGKQYFGEKTLDAIVLNY 411

Human   661 TTDLEGSDMLVEKADRRE-FIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCF 724
            ........:..|:.:.|. |||.:|:.|.::..||.||.:..||||:|             .:.|
pombe   412 PRRKTTPKLTPEEHEERLCFIDFIKQFLELNPLKRWTPDQAKNHPFIT-------------GASF 463

Human   725 QNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQA---PSSTSATISLAN 786
            ....|.|::            |.:|          |....|:..|:.|||   ||...|:..::|
pombe   464 SQYCIDKQK------------PLLT----------TQRTRNRSHTIGNQAVVPPSLQRASTYVSN 506

Human   787 -PEVSILNYPSTLYQPSA 803
             ||..:...|...|.|.|
pombe   507 EPEEFVHTRPLPQYYPPA 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	145/357 (41%)
ppk15	NP_593830.1	PKc_YAK1	130..458	CDD:271114	139/330 (42%)