Protein Alignment HIPK2 and hpk-1

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_741761.1
• Gene: hpk-1 / 180695
• WormBaseID: WBGene00001994
• Length: 846
• Species: Caenorhabditis elegans
• Alignment Length: 944
• Identity: 376/944 - (39%)
• Similarity: 475/944 - (50%)
• Gaps: 244/944 - (25%)

Human   285 QVLGGPHNLMRRSTVSLL----------------DTYQKCGLKRKSEEIEN--------TSSV-- 323
            ::|..|..|:.:|.::|.                |..|:...:|..||..|        |||.
 Worm    26 RILAPPQALLVQSQLNLTAPANPFSIQKAPGTSSDNEQRAPKRRADEEAVNAVPKNLLTTSSTFA 90

Human   324 -QIIEEHPPMIQNN---ASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCS-MTNTYEVLEF 383
             .:|...|.:...|   |..:..|||.|:|...|.||   ||:|||:::||||| ..|.||||||
 Worm    91 RAVIPAAPAISSANNKMAPQSVTATAKTTTNRGKVSG---EGEYQLIKNEVLCSPYGNQYEVLEF 152

Human   384 LGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQH 448
            ||:||||||||.||:||:|||||||||.|||||||||||||||:|||.|:::::|||||:|||.|
 Worm   153 LGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNFVRAFECFNH 217

Human   449 KNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD 513
            |:||||||||||||||||||||||.||||..|||:|.||.|||:|||||||||||||||||||||
 Worm   218 KSHTCLVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVD 282

Human   514 PSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWP 578
            |.:|||||||||||||||.||||.:|||||||||||||||||||.|:||||||||||||||||||
 Worm   283 PQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWP 347

Human   579 LYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNR-DTDSPY------PLWRLKTPDDHEAE 636
            ||||:|||||||:|.||||||...:|.:.:|..|||.. .::||.      ..:||||.:::||.
 Worm   348 LYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEAS 412

Human   637 TG-IKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIET 700
            :. .||||.||||||.:||:::|....:.:..:.|.::.||:||:|:|||||.::.|.||||.|.
 Worm   413 SSTAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEG 477

Human   701 LNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNN 765
            |...||||||:..:..:.:|....:.||||::             |......|..:.|:.    .
 Worm   478 LESKFVTMTHINGYNFANYVHEAHKRMEICRK-------------PGPAMATPYRAANVA----T 525

Human   766 QLTTVHN-QAPSSTSATISLANPEVSIL---------NYPSTLYQPSAAS-MAAVAQRSMPLQTG 819
            .:|.|.. .||       .|..|.:::|         |.|....||...: |...:|  |...||
 Worm   526 PITPVEKPPAP-------KLQQPMIAVLPQLNQIAATNIPPVPTQPDLTNLMHHYSQ--MAAATG 581

Human   820 TAQICAR-------PDP-FQQALI-----VCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGA 871
            :|...|:       |.| ||.|.:     ..||.|..| |:||.                ..|..
 Worm   582 SAATAAQFFYQPLPPAPLFQYAQLHHPFAARPPHFLSL-ATPSH----------------MVPQF 629

Human   872 QPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAH 936
            .|:.|....:.|..||        |.|.||...:|
 Worm   630 VPVPIMDPSMLQGQWP--------PGAAQQFAVLA------------------------------ 656

Human   937 GSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQH-QSSVRNVSTCEVSS 1000
                |.||:          :||.|.:|        |...||..:....|. .||:.:.:|....:
 Worm   657 ----NDIMR----------VPAPQGIN--------QMFASTPQTFSLPQFLSSSIPSATTAFNGN 699

Human  1001 SQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGW--GDVASSTTRERQRQTIVI------- 1056
            :..|..|:      ||:                   .|  |..|....::.||...:|
 Worm   700 APNIPFPE------ENS-------------------SWALGTAAQQQQQQAQRAQSMINGNVKVK 739

Human  1057 -----PDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYS 1116
                 |...||..||||:|||.|.                         :.:..|:|.|.|
 Worm   740 PLAAQPKKNSPAPSVITLSSDEDS-------------------------NGAGSSNSGSTT---- 775

Human  1117 VQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPP 1150
               |.|..|....||   |....|.....|:|||
 Worm   776 ---RTGAVNPVRNDT---LPMGNTIKTEDILVPP 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	249/362 (69%)
hpk-1	NP_741761.1	Protein Kinases, catalytic domain	147..483	CDD:473864	234/335 (70%)
		Atrophin-1	<498..>758	CDD:460830	79/387 (20%)