Protein Alignment HIPK2 and Hipk2

DIOPT Version :10

• Sequence 1: XP_011514379.1
• Gene: HIPK2 / 28996
• HGNCID: 14402
• Length: 1377
• Species: Homo sapiens
• Sequence 2: NP_034563.2
• Gene: Hipk2 / 15258
• MGIID: 1314872
• Length: 1196
• Species: Mus musculus
• Alignment Length: 1193
• Identity: 1153/1193 - (96%)
• Similarity: 1168/1193 - (97%)
• Gaps: 4/1193 - (0%)

Human   186 GMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSL 250
            ||||||||||||||||||||||||||:|||||||||||||||||||||||||.||||:|||||||
Mouse     7 GMASHVQVFSPHTLQSSAFCSVKKLKVEPSSNWDMTGYGSHSKVYSQSKNIPPSQPASTTVSTSL 71

Human   251 PVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSE 315
            |:|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    72 PIPNPSLPYEQTIIFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSE 136

Human   316 EIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEV 380
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   137 EIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEV 201

Human   381 LEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYEC 445
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   202 LEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYEC 266

Human   446 FQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIM 510
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   267 FQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIM 331

Human   511 LVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL 575
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   332 LVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFL 396

Human   576 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIK 640
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   397 GWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIK 461

Human   641 SKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 705
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Mouse   462 SKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRVTPIETLNHPF 526

Human   706 VTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTV 770
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   527 VTMTHLLDFPHSAHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTV 591

Human   771 HNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALI 835
            |||||:::|||:||||||||||||.|.|||||||||||||.||||||||||||||||||||||||
Mouse   592 HNQAPTTSSATLSLANPEVSILNYQSALYQPSAASMAAVAPRSMPLQTGTAQICARPDPFQQALI 656

Human   836 VCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQ 900
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.|.||||||||||
Mouse   657 VCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPGGAQQILLPPAWQ 721

Human   901 QLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVG 965
            ||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   722 QLTGVATHTSVQHAAVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVG 786

Human   966 VAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPAC 1030
            |||||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
Mouse   787 VAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVTSSQAISSPQRSKRVKENTPPRCAMVHSSPAC 851

Human  1031 STSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVI 1095
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   852 STSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVI 916

Human  1096 SCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLV 1160
            |||||||||||||||||||||||||.|||..|..||||.||||||||||||||||||||||||||
Mouse   917 SCVTVHDSPYSDSSSNTSPYSVQQRTGHNGTNTLDTKGGLENHCTGNPRTIIVPPLKTQASEVLV 981

Human  1161 ECDSLVP-VNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQ 1224
            |||||.| ::.||||||:||||||.||||||||||||||||.|||||||||||||||||||||||
Mouse   982 ECDSLGPAISASHHSSSFKSKSSSTVTSTSGHSSGSSSGAIAYRQQRPGPHFQQQQPLNLSQAQQ 1046

Human  1225 HITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAA 1289
            |:..||||||||||||||||||||||:|||||||||||||||   ||||||||||||||||||.|
Mouse  1047 HMAADRTGSHRRQQAYITPTMAQAPYTFPHNSPSHGTVHPHL---AAAAHLPTQPHLYTYTAPTA 1108

Human  1290 LGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISA 1354
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1109 LGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISA 1173

Human  1355 SPASTVYTGYPLSPAKVNQYPYI 1377
            |||||||||||||||||||||||
Mouse  1174 SPASTVYTGYPLSPAKVNQYPYI 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	352/353 (100%)
Hipk2	NP_034563.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..69		16/18 (89%)
		Transcriptional corepression	97..230		132/132 (100%)
		STKc_HIPK2	183..537	CDD:271129	352/353 (100%)
		Interaction with DAXX. /evidence=ECO:0000250	189..520		329/330 (100%)
		Interaction with SKI and SMAD1. /evidence=ECO:0000250	539..844		292/304 (96%)
		Interaction with DAZAP2. /evidence=ECO:0000250|UniProtKB:Q9H2X6	600..800		192/199 (96%)
		Interaction with POU4F1. /evidence=ECO:0000269|PubMed:15492043	752..897		143/144 (99%)
		Interaction with CTBP1. /evidence=ECO:0000269|PubMed:14567915	774..876		100/101 (99%)
		Interaction with HMGA1. /evidence=ECO:0000269|PubMed:11593421	787..897		108/109 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	792..847		53/54 (98%)
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	802..805		2/2 (100%)
		Nuclear localization signal 2 (NLS2). /evidence=ECO:0000250	832..835		2/2 (100%)
		Interaction with TP53 and TP73. /evidence=ECO:0000269|PubMed:11780126	839..934		94/94 (100%)
		Localization to nuclear speckles	873..980		100/106 (94%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	873..980		100/106 (94%)
		Interaction with UBE2I. /evidence=ECO:0000269|PubMed:10535925	873..907		33/33 (100%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	884..908		23/23 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..963		65/71 (92%)
		Interaction with AXIN1. /evidence=ECO:0000269|PubMed:15526030	935..1050		99/114 (87%)
		Autoinhibitory domain (AID). /evidence=ECO:0000250	984..1196		198/214 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	991..1058		58/66 (88%)