DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIK3 and Ir8a

DIOPT Version :9

Sequence 1:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens
Sequence 2:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster

Alignment Length:	882	Identity:	229/882 - (25%)
Similarity:	364/882 - (41%)	Gaps:	198/882 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   162 AILDLVQYLKWRSA-TVVYDDSTGLIRLQELI----------MAPSRYNIRLKIRQLPIDSDDSR 215
            |::||. |..|... .:|.....|.:||:.::          |...|.|   .:..:.:::.|:.
  Fly    84 AVIDLT-YSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRAN---NVAMVFMNARDAV 144

Human   216 PLLKEMKRGREFR-IIFDCSHTMAAQ-----------------ILKQAMAMGMMTE--------- 253
            ..:::|..|..|| :|.|.|.|...|                 :..:|.||..:.|
  Fly   145 EAMQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQ 209

Human   254 ---YYHFIFTTLDLYALDLE----PYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSE 311
               .:||:|       ||..    .||......|.|.:    ||.  ||.....|..|...
  Fly   210 RPLEWHFVF-------LDTRDRVFKYRRQAELCTRFTL----NPR--AICRSMPMPDLYCG---- 257

Human   312 SGLLDGVMMTDAALLYDAVHIVSV--------------CYQRAPQMTVNSLQCHRHKAWRFGGRF 362
                .|..|..|.||.....:::.              |...|....|:.........|.....:
  Fly   258 ----SGFTMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVHW 318

Human   363 MNFIKEA--------QWE----GLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLN 415
            .||:..|        |::    |||  ...|.::|        ..|.:.:....:..||
  Fly   319 SNFLAYAPPLPHIQDQFQSPVPGLT--FAVNISAG--------YYSSEHEAKTDLAAWS------ 367

Human   416 ITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSD------RTLYGNDRFEGYCIDLLKELA 474
              .|.:.|..|.|.|...|...:.|....|:...|:.:      |...|...:||||||.:..|:
  Fly   368 --SVGEMRLLNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLS 430

Human   475 HILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFM-TL 538
            ..|.|.:||...|.|..|..::.|:|:|:|.:|:..:.|.|:|.|.:...||:.|||..|:. ..
  Fly   431 QKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQT 495

Human   539 GVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYD---AHP--CN 598
            |:||..||| ....|:|.|:..|..::|:.::.|.:|.:.:::.:.::|||...:   |:|  |
  Fly   496 GISIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC- 558

Human   599 PGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTV 663
                   ..|||..||||.:.|...||....|||:|.|::...:|.|.:::::::||||||||||
  Fly   559 -------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTV 616

Human   664 ERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKIS--TFEKMW------------------ 708
            |||::|:.|.:.||:|::|.|..|||..|..:|...|.:  |..:||
  Fly   617 ERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWD 681

Human   709 ------------AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLID 761
                        |..||:|.|..|.....:.....||||.:.:|..|:|...||||||::|.:..
  Fly   682 YPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFA 746

Human   762 SKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGS---GCPEEENKEASALGIQKIGG 823
            .:.|.:....||...|:::.|||:||::.....:|.|:|..|   .||..|::|  .:.::.:||
  Fly   747 EQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE--GITLESLGG 809

Human   824 IFIVLAAGLVLSVLVAVGEFVY-----------KLRKTAEREQRSFCSTVADEIRFSLTCQR--- 874
            :||....||||:::....|.:|           ::|...:.......|:.|.....|.|.|.
  Fly   810 VFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQVRPVNDSSGSGGNSSTAPPTATSTTKQAWHI 874

Human   875 ---RVKHKP---QPPMMVKTDAVINMHTFNDRRLPGK 905
               ..:.||   .||...:|      .||..::||.:
  Fly   875 PVLEAEEKPAKVSPPPSFET------ATFRGKKLPAR 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	62/325 (19%)
		ANF_receptor	55..398	CDD:279440	60/306 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	131/411 (32%)
		Lig_chan	564..832	CDD:278489	96/307 (31%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	131/411 (32%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	96/307 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810