Protein Alignment GRIK2 and GluRIIC

DIOPT Version :10

• Sequence 1: NP_068775.1
• Gene: GRIK2 / 2898
• HGNCID: 4580
• Length: 908
• Species: Homo sapiens
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 946
• Identity: 277/946 - (29%)
• Similarity: 456/946 - (48%)
• Gaps: 149/946 - (15%)

Human    19 LLLCLLWIGY----SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYD 79
            |||..:|..:    |:|  ..:..|..| |.:...:   |..|...||.||...:
  Fly     6 LLLGCMWSAFFMCRSRG--QQINIGAFF-YDDELEL---EKEFMTVVNAINGPES---------- 54

Human    80 TQKINLY----------DSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134
            .|.:..|          .|....:.|||.:..|||||||||..::::.|..:||:.|:|||:
  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIE--- 116

Human   135 KHQVSDN-------KDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVY--DDSTGLIRLQELIK 190
             ..:||.       .....::|||..:.||:|..|:||.|.|:..|:||  ||:....|||:|::
  Fly   117 -FDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ 180

Human   191 APSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYI 255
            ....:|..:::|:...| .|.:.:.|.: || |..|:.||...|...:|..:...|:..:|.|..
  Fly   181 LREVHNDVVRVRKFHKD-DDFRVMWKSI-RG-ERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIF 242

Human   256 FTTLDLF-------ALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
            .|.|:.:       |.|.|.:   .||:|..|:|..                   |..|...|..
  Fly   243 LTNLETYTDHLEELAADNETF---AVNITAARLLVN-------------------PDPPPYSLPY 285

Human   314 GFMTTDAALMYDA-------VH-VVSVAVQQFPQ------------MTVSSLQC----NRHKPWR 354
            |::|....::|::       :| ::..|:|.|.|            |.|..:.|    :..:.|.
  Fly   286 GYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWA 350

Human   355 FGTRFMSLIKEAHWEGLTGRITFNKTN-----------GLRTDFDLDVISLKEEGLEKIG--TWD 406
            .|.....|:|     |.:|   .|.||           |.|..|:::|.    :.|:.||  .||
  Fly   351 MGRYLARLMK-----GTSG---VNNTNFRTSILQFDEDGQRITFNIEVY----DPLDGIGIAIWD 403

Human   407 PASGLNMTESQKGKPANITDSLSNRSLI--VTTILEEPYVLFKKSDKP--LYGNDRFEGYCIDLL 467
            |...:....         .|..:.:.:|  |.|.:..||..:.::.:.  |.||..::||.:||:
  Fly   404 PRGQITQLN---------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLI 459

Human   468 RELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
            ..::..:||.|....|.|.:||..|....||||::.|:|::.|.:.:..|.||..|:..:||:.|
  Fly   460 DAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVP 524

Human   533 FMTLGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCN 596
            ||.||:||| |:.|: ....:.::|.|...::|::||::...::.:..::||.|..:|.||||||
  Fly   525 FMQLGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCN 588

Human   597 PDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTV 661
            .|.:|:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:|||||||||||.
  Fly   589 RDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTS 653

Human   662 ERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQ 726
            .:||..|.:..||:.|.|:::|.:..|:|......|..:.|...:..|::...|...|.|.||:.
  Fly   654 SKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVD 718

Human   727 RVLTS--DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEG 789
            ||..:  ||.||||:||:|:..::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|
  Fly   719 RVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERG 783

Human   790 KLHMMKEKWWR--GNGCPEEESKEASA-LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQ 851
            :|:.:|:|||:  ...|.||...:|:. :..:.:.|||..|.||::::..:.:.|||...::.|.
  Fly   784 ELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVAL 848

Human   852 LEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKT 887
            .|:.:|..|..:|:|..|......|     |::..|
  Fly   849 EERLTFKDAFKKEIRFVLCVWNNRK-----PIVAGT 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK2	NP_068775.1	PBP1_iGluR_Kainate	37..414	CDD:380605	112/439 (26%)
		Periplasmic_Binding_Protein_Type_2	430..800	CDD:473866	134/376 (36%)
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	112/437 (26%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	133/371 (36%)
		Lig_chan	554..827	CDD:459656	98/272 (36%)