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Protein Alignment GRIK2 and GluRIIC

DIOPT Version :9

Sequence 1:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	277/946 - (29%)
Similarity:	456/946 - (48%)	Gaps:	149/946 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    19 LLLCLLWIGY----SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYD 79
            |||..:|..:    |:|  ..:..|..| |.:...:   |..|...||.||...:
  Fly     6 LLLGCMWSAFFMCRSRG--QQINIGAFF-YDDELEL---EKEFMTVVNAINGPES---------- 54

Human    80 TQKINLY----------DSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134
            .|.:..|          .|....:.|||.:..|||||||||..::::.|..:||:.|:|||:
  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIE--- 116

Human   135 KHQVSDN-------KDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVY--DDSTGLIRLQELIK 190
             ..:||.       .....::|||..:.||:|..|:||.|.|:..|:||  ||:....|||:|::
  Fly   117 -FDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ 180

Human   191 APSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYI 255
            ....:|..:::|:...| .|.:.:.|.: || |..|:.||...|...:|..:...|:..:|.|..
  Fly   181 LREVHNDVVRVRKFHKD-DDFRVMWKSI-RG-ERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIF 242

Human   256 FTTLDLF-------ALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
            .|.|:.:       |.|.|.:   .||:|..|:|..                   |..|...|..
  Fly   243 LTNLETYTDHLEELAADNETF---AVNITAARLLVN-------------------PDPPPYSLPY 285

Human   314 GFMTTDAALMYDA-------VH-VVSVAVQQFPQ------------MTVSSLQC----NRHKPWR 354
            |::|....::|::       :| ::..|:|.|.|            |.|..:.|    :..:.|.
  Fly   286 GYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWA 350

Human   355 FGTRFMSLIKEAHWEGLTGRITFNKTN-----------GLRTDFDLDVISLKEEGLEKIG--TWD 406
            .|.....|:|     |.:|   .|.||           |.|..|:::|.    :.|:.||  .||
  Fly   351 MGRYLARLMK-----GTSG---VNNTNFRTSILQFDEDGQRITFNIEVY----DPLDGIGIAIWD 403

Human   407 PASGLNMTESQKGKPANITDSLSNRSLI--VTTILEEPYVLFKKSDKP--LYGNDRFEGYCIDLL 467
            |...:....         .|..:.:.:|  |.|.:..||..:.::.:.  |.||..::||.:||:
  Fly   404 PRGQITQLN---------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLI 459

Human   468 RELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
            ..::..:||.|....|.|.:||..|....||||::.|:|::.|.:.:..|.||..|:..:||:.|
  Fly   460 DAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVP 524

Human   533 FMTLGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCN 596
            ||.||:||| |:.|: ....:.::|.|...::|::||::...::.:..::||.|..:|.||||||
  Fly   525 FMQLGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCN 588

Human   597 PDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTV 661
            .|.:|:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:|||||||||||.
  Fly   589 RDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTS 653

Human   662 ERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQ 726
            .:||..|.:..||:.|.|:::|.:..|:|......|..:.|...:..|::...|...|.|.||:.
  Fly   654 SKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVD 718

Human   727 RVLTS--DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEG 789
            ||..:  ||.||||:||:|:..::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|
  Fly   719 RVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERG 783

Human   790 KLHMMKEKWWR--GNGCPEEESKEASA-LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQ 851
            :|:.:|:|||:  ...|.||...:|:. :..:.:.|||..|.||::::..:.:.|||...::.|.
  Fly   784 ELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVAL 848

Human   852 LEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKT 887
            .|:.:|..|..:|:|..|......|     |::..|
  Fly   849 EERLTFKDAFKKEIRFVLCVWNNRK-----PIVAGT 879

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.