DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GRIK2 and Ir8a

DIOPT Version :9

Sequence 1:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens
Sequence 2:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster


Alignment Length:1025 Identity:242/1025 - (23%)
Similarity:406/1025 - (39%) Gaps:257/1025 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNR--------------- 68
            ||:.||          .|||.           |:|.|...|.:..:.|..               
  Fly     5 LLVLLL----------ALRFA-----------GSEVLKITFWIEPVQRAEFDTDIAMVLKELDAL 48

Human    69 ---TLLPNTTLTYDTQKINLYDSFEASKKACDQLS-LGVAAIFGPSHS---SSANAVQSICNALG 126
               ..:.:||||....:..|     ..::.|:.|| :|.:|:...::|   ...|.|:|    ||
  Fly    49 RLDVKVDDTTLTLTRSEDGL-----DMQRFCEILSTVGASAVIDLTYSHWEEGYNLVRS----LG 104

Human   127 VPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKA 191
            :.:::.       :.....::.::.||....||          ..|.:|:      :..::.::|
  Fly   105 IGYVRL-------ERIMRPFLDMFGDFMRQKRA----------NNVAMVF------MNARDAVEA 146

Human   192 PSRYNLRLKIRQLPADTKDAKP------LLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTE 250
            ..:..:....|.|..|.....|      .::.::....:..:|..:..| .||.::.....:...
  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAM-NGIFEKVQKADLFQR 210

Human   251 --YYHYIFTTLDLFALD----VEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDS 309
              .:|::|       ||    |..||......|.|    |.|.:..          .::.|.||.
  Fly   211 PLEWHFVF-------LDTRDRVFKYRRQAELCTRF----TLNPRAI----------CRSMPMPDL 254

Human   310 GLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ-CNRHKPWRFGTRFMSLIKE-------- 365
            ....|| |...|::.:.:..:..|.|..|...::..| ||       .|...|.:.:        
  Fly   255 YCGSGF-TMQRAMLLNVLRSLINAAQVSPGYPLAIYQDCN-------ATASSSEVSDPLEKDDYN 311

Human   366 ----AHWE---------------------GLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTW 405
                .||.                     |||          ...:......|.:.|....:..|
  Fly   312 WLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLT----------FAVNISAGYYSSEHEAKTDLAAW 366

Human   406 DPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSD------KPLYGNDRFEGYCI 464
            .....:.:        .|.|.|.:.|...:.|....|:...::.:      :...|...:|||||
  Fly   367 SSVGEMRL--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCI 423

Human   465 DLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDF 529
            |.:..||..|.|.:||...|.|..|..::. |:|:|:|.:|:..:.|.|:|.|.:...||:||||
  Fly   424 DFIIRLSQKLNFEFEIVAPEVGHMGELNEL-GEWDGVVGDLVRGETDFAIAALKMYSEREEVIDF 487

Human   530 SKPFM-TLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYN-- 591
            ..|:. ..||||..||| .....:|.|:..|..::|:.|:.|.:|.:.:::.:.::|||...|  
  Fly   488 LPPYYEQTGISIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNR 551

Human   592 ---PHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 653
               |:.|        ..|||..||||.:.:...||....|||:|.|::...:|.|.:::::::||
  Fly   552 QAYPYAC--------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTA 608

Human   654 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIS--TYDKMW---AFMSSR- 712
            |||||||||||::|:.|.:.||:|::|.|..|:|..|..:|...|.:  |..:||   |..:|: 
  Fly   609 NLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKD 673

Human   713 ----------------------RQSVLVKSNEEGIQRV---LTSDYAFLMESTTIEFVTQRNCNL 752
                                  ..|..|...:||...|   ..:||||:.:|..|::...|||||
  Fly   674 FKKFRIWDYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNL 738

Human   753 TQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN---GCPEEESKEASA 814
            |::|.:...:.|.|....||...|:::.|||:||::.....:|.|:|..:   .||..|.:|...
  Fly   739 TEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGIT 803

Human   815 LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELR------------- 866
            |  :::||:||....||||::.....|.||..||...||        :.::|             
  Fly   804 L--ESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE--------ITQVRPVNDSSGSGGNSS 858

Human   867 ----MSLKCQRRLKHKP-----QAPVIVKTEEVINMHTFNDRRLPGKETM 907
                .:....::..|.|     :.|..|.........||..::||.:.|:
  Fly   859 TAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARITL 908

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 72/444 (16%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 131/412 (32%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)