DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACAD9 and Acox57D-d

DIOPT Version :9

Sequence 1:	NP_054768.2	Gene:	ACAD9 / 28976	HGNCID:	21497	Length:	621	Species:	Homo sapiens
Sequence 2:	NP_523803.1	Gene:	Acox57D-d / 37446	FlyBaseID:	FBgn0034629	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	722	Identity:	139/722 - (19%)
Similarity:	228/722 - (31%)	Gaps:	260/722 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    18 RGLVVSTANRRLLRTSPPVRAFAKELFL------GKIKKKEVFPFPEVSQDELNEINQFLGPVEK 76
            :.|:.||.|..|.:.........:|...      .|:|||.     |:.:...:::....|...:
  Fly     5 KNLIPSTVNPDLQKERAAAEFHVEEFSAWWHGGQDKLKKKR-----EIEKAIFSDLEDGYGLNHE 64

Human    77 FFT-EEVDSRKIDQEGKIPDETLEKLKSL--------------GLFGLQVPEEYGGLGFSNTMYS 126
            :.: |||.:..:    |...|...|||:|              |||..|   .:|....::.:.:
  Fly    65 YMSHEEVYNSTV----KKVAEAAVKLKALQNKLNPGGTDIWPGGLFNAQ---SFGLFPANHPIAT 122

Human   127 RLGEIISMDGSITVTLAAHQAIGLKGIILAGTEEQKAKYLPKLASGEHIAAFCLTEPASGSDAAS 191
            .:...:.:               :||   .||.||..|:.....:...|..:..||.|.|::...
  Fly   123 HITMFVDV---------------IKG---QGTAEQVEKWGKAAENCNIIGTYAQTELAHGTNVRG 169

Human   192 IRSRATLSEDKKHYILN-----GSKVWITNGGL---ANIFTVFAKTEVVDSDGSVKDKITAFIVE 248
            :.:||........::||     ..|.|  .|||   ||...|.|:..:.|    |...:..|||.
  Fly   170 LATRADFDPKTDEFVLNTPNLEAYKWW--PGGLGHTANHAMVVAQLYIAD----VHHGVQMFIVP 228

Human   249 -RD------FGGVTNGKPEDKLGIRGSNTCEVHFENTKIPVENILGEVG----DG-FKVA----M 297
             ||      ..||..|:...|||:...|...:...:.:||..|:|.:..    || ||.:    :
  Fly   229 LRDSETHMPLPGVDIGEIGKKLGMASVNQGFLGLNHVRIPRTNMLMKFAKVERDGTFKASPASRI 293

Human   298 NILNS--GRFSMGSVVAGLLKRLIEMTAEYACTRKQ---------------FNKRLSEFGLIQEK 345
            |.|..  .|..:.|..:.||.....:...|:..|:|               ..:||..|..|...
  Fly   294 NYLTMVYTRCLIVSQNSTLLLAAATIATRYSAVRRQSPIEPNQPEPQIIDHVTQRLKLFPEIATG 358

Human   346 FA--LMAQKAYVMESMTYLTAGMLDQPGFPD-----CSIEA------------------------ 379
            .|  |..:..:.|.:.|...|........||     |:::.
  Fly   359 IAYHLATEYMWEMYAQTVQEANNGKFERLPDMHILSCALKVLCTTDGCAGIEKLRLSTGGHGYLI 423

Human   380 ------------------------------AMVKVFSS--------------------------E 388
                                          |:||.::|                          :
  Fly   424 AANLSNIYGNAVAAYTYEGENTVLLLQIGRALVKAWASFVDKKPLSASYSYFASSMQLKEFPKWD 488

Human   389 AAWQCVSEALQILG----------------------------GLGYT-------RDYPYERIL-- 416
            .:|||:.:|||...                            |:..|       |.:..:..|
  Fly   489 DSWQCIIKALQYTAAHKTRIAFENLANRMASGQSQGVAANNTGIELTRAAELHGRQFVCQTFLEQ 553

Human   417 --------RDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHELKQAKVSTVMDTVGRRLRD 473
                    |...:..|.|   .:|.:::..|.|.:...||  |..:|..|.:.::.    :||.|
  Fly   554 ITGAKAQKRSPALNKILE---NVLELFLVQTVLNNLNDIL--RFIKLSDADLRSLQ----KRLED 609

Human   474 SLG-----------------RTVDLGLTGNHGVVHPSLADSANKFEENTYCFGRTVETLLLRFGK 521
            ||.                 |.::..|....|.|:|.|.|||.:...|.    :.|:|....:.|
  Fly   610 SLAQFRPNAVAICDGFEFHDRVLNSVLGSYDGNVYPRLFDSAKRSTMNQ----KPVQTSFETYLK 670

Human   522 TIMEEQL 528
            .:|:.:|
  Fly   671 PLMKAKL 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACAD9	NP_054768.2	VLCAD	38..445	CDD:173850	109/600 (18%)
Acox57D-d	NP_523803.1	ACAD	14..653	CDD:299127	129/683 (19%)
Acox57D-d	NP_523803.1	PLN02443	16..677	CDD:178062	134/709 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810