DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACAD9 and CG7461

DIOPT Version :9

Sequence 1:	NP_054768.2	Gene:	ACAD9 / 28976	HGNCID:	21497	Length:	621	Species:	Homo sapiens
Sequence 2:	NP_001286611.1	Gene:	CG7461 / 37217	FlyBaseID:	FBgn0034432	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	621	Identity:	280/621 - (45%)
Similarity:	384/621 - (61%)	Gaps:	25/621 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    14 ARACRGLVV------STANRRLLRTSPPVRAFAKELFLGKIKKKEVFPFPEVSQDELNEI-NQFL 71
            |..||.:..      :.:||...:.|.. .:|...:|.|.:...:|||:|:|...|..|: |..:
  Fly    16 ASLCRQIATHSPKLGAESNRSKEKASEN-ESFMANIFRGSLVSSQVFPYPDVLTAEQKELTNSLI 79

Human    72 GPVEKFFTEEVDSRKIDQEGKIPDETLEKLKSLGLFGLQVPEEYGGLGFSNTMYSRLGEIISM-D 135
            .|.|:||::..|:.:.|...||.|.|...|..||.||:|||.|:||||.:||.|.||..|:.: |
  Fly    80 DPFERFFSDVNDAARNDANSKIDDTTSTALWELGAFGIQVPSEFGGLGLNNTQYGRLCAIVGVND 144

Human   136 GSITVTLAAHQAIGLKGIILAGTEEQKAKYLPKLASGEHIAAFCLTEPASGSDAASIRSRATLSE 200
            ..:.:|:.|||:||.|||:|.||.|||.|||||:|:.:..|||.||||:|||||.|||.||..|.
  Fly   145 LGLGITIGAHQSIGFKGILLYGTPEQKEKYLPKVAAEQVYAAFALTEPSSGSDAGSIRCRAVKSA 209

Human   201 DKKHYILNGSKVWITNGGLANIFTVFAKTEVVD-SDGSVKDKITAFIVERDFGGVTNGKPEDKLG 264
            |.|||:|||||:||:|||:|.|.||||:||.|| ..|..|||:|||||||.|||||||.||.|:|
  Fly   210 DGKHYVLNGSKIWISNGGIAEIMTVFAQTEQVDPKTGEKKDKVTAFIVERSFGGVTNGPPEKKMG 274

Human   265 IRGSNTCEVHFENTKIPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTR 329
            |:.|||.||:||:.|||:||:||:.||||||||||||:|||.||:.::|.:|:.||...|:|..|
  Fly   275 IKASNTAEVYFEDVKIPIENVLGKEGDGFKVAMNILNNGRFGMGATLSGTMKKCIEQATEHANNR 339

Human   330 KQFNKRLSEFGLIQEKFALMAQKAYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQCV 394
            .||.::|..:|.||||.|.|....|..|||.:..:..:| .|..|..:|||:.|:::||:||...
  Fly   340 VQFGQKLKNYGSIQEKLAQMNILQYATESMAFTISQNMD-AGSKDYHLEAAISKIYASESAWYVC 403

Human   395 SEALQILGGLGYTRDYPYERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHELKQ-- 457
            .||:|||||:||..|...||:|||.||..||||||:|||::|||||:|:||    :.:.||::
  Fly   404 DEAIQILGGMGYMVDNGLERVLRDLRIFRIFEGTNDILRLFIALTGIQYAG----SHLKELQRAF 464

Human   458 ----AKVSTVMDTVGRRLRDSLGRTVDLGLTGNHGVVHPSLADSANKFEENTYCFGRTVETLLLR 518
                |.:..:.....||    ...||.||.|...|.|...|...|.|.......||::||.||||
  Fly   465 KNPSANLGLIFKEASRR----AASTVGLGGTDLSGHVVGELLPYAKKTAHCIDLFGQSVEELLLR 525

Human   519 FGKTIMEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLRNHDHEVLLANTFCVEAYLQNLFSL 583
            :.|.|:.||::|.|:||..|::|.|....||:||::.:.|....||:.:.....::|..:.:.:|
  Fly   526 YNKNIVNEQILLTRLANAAIDIYAMVVTQSRSSRAVNLNLPTAQHELNMTKALTIQASDRVIKNL 590

Human   584 SQLDKYAPENLDEQIKKVSQQILEKRAYICAHPLDR 619
            .........:|:|:|..:::..||.........||:
  Fly   591 QAATSSHHRSLNEKISTIAKTTLENGGVTTTGILDQ 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACAD9	NP_054768.2	VLCAD	38..445	CDD:173850	222/409 (54%)
CG7461	NP_001286611.1	VLCAD	45..454	CDD:173850	222/409 (54%)
CG7461	NP_001286611.1	CaiA	67..446	CDD:224871	208/379 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56772
OrthoDB	1	1.010	-	-		D163462at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X967
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730