Protein Alignment GRIK1 and GluRIB

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 978
• Identity: 331/978 - (33%)
• Similarity: 506/978 - (51%)
• Gaps: 192/978 - (19%)

Human    39 IGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQR----INLFDSFEASRRACDQ 99
            :|.|||...:|    .:.|||:|:.:.|.|     .::..:::|.    ||..|:|:.||..|:|
  Fly    44 LGAIFEQGTDE----VQSAFKYAMLNHNLN-----VSSRRFELQAYVDVINTADAFKLSRLICNQ 99

Human   100 LALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW-----KHPSVDNKDLFYINLYPDYAAISR 159
            .:.||.::.|.....|...:.|..|..::|.: |.|     ..||....| |.:::.|||   .:
  Fly   100 FSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFV-TPWFPEKVLTPSSGFLD-FALSMRPDY---HQ 159

Human   160 AILDLVLYYNWKTVTVVYEDSTGLIRLQELIKA--PSRYNIKIKIRQLPSGNKDAKPLLKEMKKG 222
            ||:|.:.:|.|:.:..:|:...||:|||::.:.  |...:.::::.:..|....|...|..:::.
  Fly   160 AIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTLEQI 224

Human   223 KEF---YVIFDCSHETAAEILKQ---ILFMGMMTEYYHYFFTTL---DLFALDLELYRYSGVNMT 278
            ..|   :::.||..|.|.:||.|   .|.:|..|  |||..:.|   |.:  :.|:..:..:|:|
  Fly   225 GRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRT--YHYLLSGLVMDDRW--ESEIIEFGAINIT 285

Human   279 GFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIA--------- 334
            |||:::.:...|....:.|  :||.  |:...|.....::.:||||||||:::..|
  Fly   286 GFRIVDTNRRLVREFYDSW--KRLD--PQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKP 346

Human   335 -------SHRASQLTVS-------------------------------------------SLQCH 349
                   ..|:..|.|:                                           :|.|:
  Fly   347 DQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCN 411

Human   350 RHK----PWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKH 410
            ..|    .|..|.:....:::...:||||.|.|| .:|.|.::.|.::    |.|..:|
  Fly   412 TAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFN-DDGRRVNYTLHVV----EMTVNSA------ 465

Human   411 LYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRK--SDKPLYGND 473
                ..|:..||.::||...::...:.....:...|||.||||:|||||:|.::  ..:.|:||:
  Fly   466 ----MVKVAEWNDDAGLQPLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNN 526

Human   474 RFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDK--GEWNGMVKELIDHRADLAVAPLTITY 536
            ||||||.||...|:..||..|:::||.||.||::...  |.|:|||.||:...||:|:|.:|||.
  Fly   527 RFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITA 591

Human   537 VREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTP 601
            .||:|||||||||:|||||:.:||....||||||:||||.:||:.|:.:.:|||.|||.::||:|
  Fly   592 ERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSP 656

Human   602 YEWY------------NPH--------------------PCNP---------------------- 612
            :||.            :||                    |..|
  Fly   657 HEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSA 721

Human   613 -------DSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 670
                   .|..|.|.|::.|||||.:.|.||||.:|.|:::|.||....|:|||||:||||||||
  Fly   722 GSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANL 786

Human   671 AAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRN 735
            |||||||||.:||:|.:|||.||:::||.:..|||..||::|:|..:.|||.:|:||:. ..|..
  Fly   787 AAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRKH-VFVPT 850

Human   736 SDEGIQRVLTT--DYALLMESTSIEYVTQRN-CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797
            .||||:||..:  .||||:||...|||..|. |:..::|..:|:||:|:.||:||..:|.|.:|:
  Fly   851 YDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAV 915

Human   798 LQLQEEGKLHMMKEKWWRGNG-CPEEDNKEA--SALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859
            |.|:|.|:|..::.|||.... |....:.|.  |.|.:.|:.|||.:|..||::||||||.|:.:
  Fly   916 LTLKENGELIKLRNKWWYEKAECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCF 980

Human   860 KSR 862
            :||
  Fly   981 RSR 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	114/474 (24%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	196/436 (45%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	114/472 (24%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	197/441 (45%)
		Lig_chan	630..966	CDD:459656	131/336 (39%)