Protein Alignment GRIK1 and GluRIID

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Alignment Length: 935
• Identity: 336/935 - (35%)
• Similarity: 503/935 - (53%)
• Gaps: 120/935 - (12%)

Human    35 QVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQ 99
            |.:|:|    .:.::..:.....|:.|::.:| |...:|   |..:.:::...:|.:|..:.|..
  Fly    32 QSIRLG----LITDDATDRIRQTFEHAISVVN-NELGVP---LVGETEQVAYGNSVQAFAQLCRL 88

Human   100 LALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPS-VDNKDLFYINLYPDYAAISRAILD 163
            :..||.|:|||:...:.|.:.:.|::.::|.|   :.|.| ..|.|.|  ||:|....|:.|:.|
  Fly    89 MQSGVGAVFGPAARHTASHLLNACDSKDIPFI---YPHLSWGSNPDGF--NLHPSPEDIANALYD 148

Human   164 LVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIK---IKIRQLPSG-NKDAKPLLKEMKKGKE 224
            :|..:.|......||.:..|..|..|:   :||.||   ||:.:.... |.:.|.:|:.::|.::
  Fly   149 IVNQFEWSRFIFCYESAEYLKILDHLM---TRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSED 210

Human   225 FYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPH 289
            ..::...|....||:|:|...:|:|.|.|.|....|:|...|||.|:||..|:||.|:.:.|...
  Fly   211 SRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEE 275

Human   290 VSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVA-IASHRASQLTVSSLQC-HRH- 351
            |..::||...|..::.| ..:|  ...:|.|.||.||||.::| ...|...|  ...|.| .||
  Fly   276 VRDLMEKLHQELGESEP-VNSG--STFITMEMALTYDAVRVIAETTKHLPYQ--PQMLNCSERHD 335

Human   352 --KPWRLGPRFMNLIK--EARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLY 412
              :|  .|..|.|.::  |.:...:||.|.|.  ..:||.|..|:|.|:..|.
  Fly   336 NVQP--DGSTFRNYMRSLEIKEKTITGRIYFE--GNVRKGFTFDVIELQTSGL------------ 384

Human   413 KVWKKIGIWNSNSGLNMTDSNKDKSSNITD----SLANRTLIV-TTILEEPYVMYRKSDKPLYGN 472
               .|:|.|  ..|.:.......::.|..|    ||.|:|.|| .::..:||....:|...|.||
  Fly   385 ---VKVGTW--EEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGN 444

Human   473 DRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWN-------GMVKELIDHRADLAVA 530
            ::|:||.:||:|||::.|||.:..:   ||    .||.|.:|       ||:||:::.|||||:.
  Fly   445 NQFQGYGVDLIKELADKLGFNFTFR---DG----GNDYGSFNKTTNSTSGMLKEIVEGRADLAIT 502

Human   531 PLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFV 595
            .||||..||:|||||.|||.|||:|||.||....|.:|||::|.|.::|:|:.:|.||||...|:
  Fly   503 DLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFI 567

Human   596 IARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL 660
            |.|.:|.||.||:||..:.:.:||.||:.||.||..|||:|||||:.|||||||.:..|||||||
  Fly   568 IGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTL 632

Human   661 IIISSYTANLAAFLTVERMESPIDSADDLA-KQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFM 724
            |::||||||||||||:|...|||:|..||| .:..::|||.|.|||..||..|:...|.||..::
  Fly   633 IMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL 697

Human   725 SSRQQTALVRNSDEGIQRVLT-TDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSP 788
            ::..: .|:.|:.:|:.:|.: |.||.||||||||:.|.|.||||::|..:|.||||:......|
  Fly   698 NAHPE-MLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWP 761

Human   789 YRDKITIAILQLQEEGKLHMMKEKWWRGNGC----PEEDNKEASALGVENIGGIFIVLAAGLVLS 849
            ||||...|:|:|||:|.|..:|.|||...|.    .:.|:...|.|||:|:.||::||..|.::|
  Fly   762 YRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIIS 826

Human   850 VFVAI---GEFIYKSRKNNDI-------EQKGKSSRIRFYFRNKVRFHGRKKQSLGVEKCLSFNA 904
            :.::|   ..|:||..||.::       |:          ||..:||...::
  Fly   827 IIISILCWCYFVYKKAKNYEVPFCDALAEE----------FRIVIRFSENER------------- 868

Human   905 IMEELGISLKNQKKIKKKSRTKGKS 929
                   .||:.:.|..:||...:|
  Fly   869 -------PLKSAQSIYSRSRNSSQS 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	113/404 (28%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	187/378 (49%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	113/406 (28%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	187/378 (49%)
		Lig_chan	547..819	CDD:459656	134/272 (49%)