Protein Alignment GRIK1 and Ir93a

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Alignment Length: 953
• Identity: 191/953 - (20%)
• Similarity: 342/953 - (35%)
• Gaps: 265/953 - (27%)

Human    42 IFETVENEPVNVEELAFK-----------FAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRR 95
            |.|.:.|..:||:..::.           ..||..........||..| .|..|.:.||
  Fly    69 IRENLRNGGINVKYFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQET-SILLIAITDS------ 126

Human    96 ACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRA 160
            .|.:|.|..|.:.                             |.|:|.|.|           .:.
  Fly   127 DCPRLPLNRALMV-----------------------------PIVENGDEF-----------PQL 151

Human   161 ILDLVL--YYNWKTVTVVYEDSTGLIRLQELIKAPSRYNI-----------------------KI 200
            |||..:  ..|||| .||:.|.|.|.....|:|:....:|                       ::
  Fly   152 ILDAKVQQILNWKT-AVVFVDQTILEENALLVKSIVHESITNHITPISLILYEINDSLRGQQKRV 215

Human   201 KIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH----YFFTTLD 261
            .:||..|   ...|  |:.::.::.:::....||...||.:.:       ..:|    :....||
  Fly   216 ALRQALS---QFAP--KKHEEMRQQFLVISAFHEDIIEIAETL-------NMFHVGNQWMIFVLD 268

Human   262 LFALDLE-----LYRYSGVNMTGFRLLNIDNPH----VSSIIEKWSMERLQAPPRPETGLLDGMM 317
            :.|.|.:     :....|.|:.  ..||..:|:    ::..|.:.|:..:.|..:         :
  Fly   269 MVARDFDAGTVTINLDEGANIA--FALNETDPNCQDSLNCTISEISLALVNAISK---------I 322

Human   318 TTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKE-----------ARWDG 371
            |.|...:|..   ::.....|.:.|....|.          ..:..:||           |||..
  Fly   323 TVEEESIYGE---ISDEEWEAIRFTKQEKQA----------EILEYMKEFLKTNAKCSSCARWRV 374

Human   372 LTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDK 436
            .|. ||:.|:...||.........|....|             :..||.|....|....:.   .
  Fly   375 ETA-ITWGKSQENRKFRSTPQRDAKNRNFE-------------FINIGYWTPVLGFVCQEL---A 422

Human   437 SSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPD 501
            ..:|.....|.|:.:.|:...|:.:..|:...:....:  |..::::||||..|.|.|.:.....
  Fly   423 FPHIEHHFRNITMDILTVHNPPWQILTKNSNGVIVEHK--GIVMEIVKELSRALNFSYYLHEASA 485

Human   502 GK-------YGAQNDKGEWNGMVKELIDHRA---------DLAVAPLTITYVREKVIDFSKPFMT 550
            .|       ....|:..|..|.:...|.:|.         .:|....|:....:|..::::|...
  Fly   486 WKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISV 550

Human   551 LGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSD 615
            ...|.:.|||:..: .::.|..|.:.:.|..::...|..:..|:.|.|..|.:         :..
  Fly   551 QKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAPLK---------EMR 605

Human   616 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERME 680
            :|..: |:.:.||:..|||:|||...:|.|.|.|:|.|.||...::::::|..||.||||..:.:
  Fly   606 IVGLS-TVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQ 669

Human   681 SPIDSADDLAKQTKI-EYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNS--DEGIQR 742
            ..:|..:.|.....| :|| :|:|   |||::...||..:.:.....|   |.:..|  :|.|:.
  Fly   670 PGVDYLNQLEDHKDIVQYG-LRNG---TFFERYVQSTTREDFKHYLER---AKIYGSAQEEDIEA 727

Human   743 V-----LTTDYALLMESTSIEYVTQRN------CNLTQIG--GLIDSKGYGVGTPIGSPYRDKIT 794
            |     :..|:.:     :::.:.||:      |:.. :|  ..:|.:
  Fly   728 VKRGERINIDWRI-----NLQLIVQRHFEREKECHFA-LGRESFVDEQ----------------- 769

Human   795 IAILQLQEEGKLHMMK------------EKW--------WRGNGCPEEDNKEASALGVENIGGIF 839
            ||::...:...||::.            |:|        .:.||...:.......:.::::.|.|
  Fly   770 IAMIVPAQSAYLHLVNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCF 834

Human   840 IVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRIRFYFRN 882
            :||..|..|::.:..|||.|:         :.::||.|..|.|
  Fly   835 LVLLLGFTLALLIVCGEFWYR---------RFRASRKRRQFTN 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	83/448 (19%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	90/420 (21%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:473866	70/284 (25%)
		Lig_chan	574..836	CDD:459656	65/301 (22%)