Protein Alignment GRIK1 and Ir85a

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Alignment Length: 722
• Identity: 132/722 - (18%)
• Similarity: 225/722 - (31%)
• Gaps: 265/722 - (36%)

Human   223 KEFYVIFD--CSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALD--LELYRYSGVNMTGFRL- 282
            |..:|.|:  .|||...:|||::              |..|:...:  ||..:..|:.|....:
  Fly    50 KVLFVYFENQTSHEHTGQILKEV--------------TKCDISNQNTPLEAVKDDGILMYMVMIT 100

Human   283 LNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDA-------------VYMVAIA 334
            .||..|...|:|.|.|    .|..|....||    ..:|..:.||             :..:.|.
  Fly   101 TNISQPLELSLIRKKS----AAKHRSHVFLL----VRDADTVSDAWMRASFRQFWKIWLLNIVIL 157

Human   335 SHRASQLTVSSLQCHRHKPWRLGPRFMN--LIKEARWDGLTGHITFNKTN---GLRKDFDLDIIS 394
            ..|..:     |..:|:.|      ||:  ||.           ..||.|   .|.:.|...|.:
  Fly   158 YWRDGR-----LNAYRYNP------FMDNYLIP-----------VDNKPNEVPTLEQLFPKTIPN 200

Human   395 LKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSL--------ANRTLIV 451
            ::.:.....       :||...:...|...:.|.            ||.|        .|.|:::
  Fly   201 MQRKPLRMC-------IYKDDVRAIFWRQGTILG------------TDGLLAAYVAERLNATMMI 246

Human   452 TTILEEPYVMYRKSDKPLYGNDRFEG-YC-LDLLKELSNI---LGFIYDVKLVPDGKYGAQNDKG 511
            |    .|:         .|.|..... .| |::.||..::   :.|     ||||
  Fly   247 T----RPH---------SYNNHNLSSDICFLEVAKEYVDVAMNIRF-----LVPD---------- 283

Human   512 EWNGMVKELIDH-RADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS 575
            .:....:..:.| |.||.|           ::..:|                |.|..::......
  Fly   284 TFRKQAESTVSHTRDDLCV-----------IVPKAK----------------TAPTFWNIFRSFG 321

Human   576 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSE 640
            ..:|..:|::.|..:...:::                .|:|......|.      .|||....::
  Fly   322 SLVWALILVSVLVANVFCYIL----------------KSEVGRVPMQLF------AGALTMPMTQ 364

Human   641 LMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ-----------TK 694
            :.|.. |.|:....|.:|.|:|.|::..||.:.:..:.....|:....||:.           ..
  Fly   365 IPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALARSHYHIIIRPRHVKH 428

Human   695 IEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYAL--------- 750
            |::       .:|...|.:....|:|.. :|..|...::||:|  |:......|.:
  Fly   429 IQH-------FLTLGHKHESRIREQMLE-VSDTQMYEMMRNND--IRFAYLEKYHIARFQVNSRV 483

Human   751 ----------LMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGK 805
                      ||.|..:.:      :...|            .|.||||...:...|....|.|
  Fly   484 HMHLGRPLFHLMNSCLVPF------HAVYI------------VPYGSPYLGFLDSLIRSSHEFG- 529

Human   806 LHMMKEKWW-------------------RGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVF 851
                .|::|                   ||:|     |.|...|.:::...:|.:...|:.::..
  Fly   530 ----FERYWDRIMNSAFIKSGVKVVNRRRGSG-----NDEPVVLKLQHFHAVFALWLVGIGMACI 585

Human   852 VAIGEFI 858
            |...|.:
  Fly   586 VLAWEHL 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	48/230 (21%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	71/423 (17%)
Ir85a	NP_649833.1	None