Protein Alignment GRIK1 and Ir75c

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_649013.3
• Gene: Ir75c / 39983
• FlyBaseID: FBgn0261401
• Length: 623
• Species: Drosophila melanogaster
• Alignment Length: 760
• Identity: 143/760 - (18%)
• Similarity: 245/760 - (32%)
• Gaps: 274/760 - (36%)

Human   210 KDAKPLLKEMKKGKEFYVIFDCSH-ETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL------ 267
            |:|.||::.:.:...|....|..: :..|.:.|         ||.......|.:| |||
  Fly    31 KEAFPLVEMLNQNGIFSQYIDVQNPDNLANVHK---------EYLDSDLVRLGVF-LDLGCDKAE 85

Human   268 ---------ELYR--------------------YSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQ 303
                     .||.                    :.|.|::    ||.|..:||...|
  Fly    86 LVTNQSSRARLYNQNLHWLLYDEAGNFTKLTQLFEGANLS----LNADVTYVSREDE-------- 138

Human   304 APPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVS---SLQCHRH--------KPWRLG 357
                            |..:::| ||..  .||...:|.::   :|||:|.        ....|.
  Fly   139 ----------------ERFILHD-VYNK--GSHLGGKLNITVDQTLQCNRSHCQVKEYLSELHLR 184

Human   358 PRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWN 422
            ||                        |:...||..::                 :::...:.:..
  Fly   185 PR------------------------LQHRMDLSSVT-----------------FRLAALVSVLP 208

Human   423 SNSG----LNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLL 483
            .||.    |...:|::|...:....:.||                                  |:
  Fly   209 INSSEEELLEFLNSDRDSHMDSISRIGNR----------------------------------LI 239

Human   484 KELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPF 548
            .....||||  .:..:..|.:..|:..|   |.:..|.:..|:|...|...::.|   :.:..|
  Fly   240 MHTQEILGF--KLHYIWCGTWSVQDAFG---GAIGMLTNESAELCTTPFVPSWNR---LHYLHP- 295

Human   549 MT----LGISILYRKPNGTNPGVFSFLNPLSPDIWMYV--LLACLGVSC-VLFVIAR-------- 598
            ||    .....::|.|:........||.|..|.:|...  ||...||.. ::|.:.|
  Fly   296 MTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSVWFAFAGLLIFAGVLLWMIFHLERHWMQRCLD 360

Human   599 FTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIII 663
            |.|                    :||:|.....||...|||.||||:...|:.      |..:::
  Fly   361 FIP--------------------SLLSSCLISFGAACIQGSYLMPKSAGGRLA------FIAVML 399

Human   664 SS------YTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIST------ 716
            :|      ||:.:.:.|....:.|.|.:...|| .:.::.|.    .|:.|.|...:|:
  Fly   400 TSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLA-DSSLDVGF----DTVPFTKTYLVSSPRPDIR 459

Human   717 --YEKMWAFMSSRQQTALVRNSDEGIQR-------VLTTDYALLMESTSIEYVTQRNCNLTQIGG 772
              |::  ...|.|...::..:.:||:.|       |.|::.:.:.......|:.:...:|.:|..
  Fly   460 SLYKQ--KVESKRDPNSVWLSPEEGVIRVRDQPGFVYTSEASFMYHFVEKHYLPREISDLNEIIL 522

Human   773 LIDSKGYGVGTPIGSPYRDKITIAILQLQEEG------------KLHMMKEKWWRGNGCPEEDNK 825
            ..:|..||: ..:.|.||..:|...:::.|.|            |||..             .|.
  Fly   523 RPESAVYGM-VHLNSTYRQLLTQLQVRMLETGITSKQSRFFSKTKLHTF-------------SNS 573

Human   826 EASALGVENIGGIFIVLAAGLVLSVFVAIGEFI---YKSRKNNDI 867
            ....:|:|....:||.|.....|::.:.|.|..   |..:|.:.|
  Fly   574 FVIQVGMEYAAPLFISLLVAYFLALLILILEICWARYAKKKFSTI 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	45/271 (17%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	84/416 (20%)
Ir75c	NP_649013.3	Lig_chan	328..>508	CDD:459656	44/212 (21%)