Protein Alignment GRIK1 and Ir75a

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 764
• Identity: 156/764 - (20%)
• Similarity: 270/764 - (35%)
• Gaps: 257/764 - (33%)

Human   225 FYVIFDC-----SHETAAEILKQI--LFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRL 282
            |.|:|.|     |.:.|.:.:|.|  :.:      ||.|                  |.|.|  :
  Fly    21 FIVLFHCWQSDESLKFAQQFMKPIHPILV------YHQF------------------VQMRG--V 59

Human   283 LNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQ 347
            ||            ||  .|:         |..|..|:..|   |:|:..........|..:|.:
  Fly    60 LN------------WS--HLE---------LSYMGHTQPTL---AIYVDIKCDQTQDLLEEASRE 98

Human   348 --CHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGL-RKDFDLDIISLKE---EGTEKAAGE 406
              .::|..|.|             .|....:.|....|| ....|.|:..:||   :..:..|..
  Fly    99 QIYNQHYHWLL-------------VGNQSKLEFYDLFGLFNISIDADVSYVKEQIQDNNDSVAYA 150

Human   407 VSKHLYKVWKKIGIWNSNSGLNMTDSN--------------------KDKSSN---ITDSLANRT 448
            | ..:|...|.||     ..||:|.|:                    :.|..|   :||.:....
  Fly   151 V-HDVYNNGKIIG-----GQLNVTGSHEMSCDPFVCRRTRHLSSLQKRSKYGNREQLTDVVLRVA 209

Human   449 LIVT----TILEEPYVMY--RKSDKPLYGNDRFEGYCLDLLKELSNI-LGFIYDVKLVPDGKYGA 506
            .:||    |:.::..:.:  :::|..:....||..:...:|::|.:. :.||:
  Fly   210 TVVTQRPLTLSDDELIRFLSQENDTHIDSLARFGFHLTLILRDLLHCKMKFIF------------ 262

Human   507 QNDKGEWN------GMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI--SI-LYRKPNG 562
               ...|:      |.|..::|..|||...|...|..|.|   :....:..|.  |: ::|.|:
  Fly   263 ---SDSWSKSDVVGGSVGAVVDQTADLTATPSLATEGRLK---YLSAIIETGFFRSVCIFRTPH- 320

Human   563 TNPGVFS--FLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYE-----W---YNPHPCNPDSDVV 617
             |.|:..  ||.|.||.:| |:....|.:..||..|..:...:     |   |.|
  Fly   321 -NAGLRGDVFLQPFSPLVW-YLFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLP---------- 373

Human   618 ENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS-----SYTANLAAFLTVE 677
                :||::|....||...|.|.|:|::...|::     :|.|.:||     .||:.:.:.|...
  Fly   374 ----SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYNYYTSVVVSSLLSS 429

Human   678 RMESPIDSADDLAKQ-----------TK--IEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQ 729
            .::|.|.:...||:.           ||  :.|..:.:   :..|.|.||.         |..|.
  Fly   430 PVKSKIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPE---IHLFIKRKIE---------SQTQN 482

Human   730 TALVRNSDEGIQRVL-TTDYALLMESTS----IE--YVTQRNCNLTQIGGLIDSKGYGVGTPI-- 785
            ..|...:::|:.||. ...|..:.|::|    :|  :..|..|:|.::....:...|   |.:
  Fly   483 PELWLPAEQGVLRVRDNPGYVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY---THLHR 544

Human   786 GSPYRDKITIAILQLQEEG------------KLHMMKEKWWRGNGCPEEDNKEASALGVENIGGI 838
            .|.|::...:..|::.|.|            |||.:.:.:             ...:|:|.:..:
  Fly   545 NSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHCVAQNF-------------VITVGMEYVAPL 596

Human   839 FIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRIRFYFRNKVRFH 887
            .::|....:|.|.:.:.|..:|                ||:.|: :.||
  Fly   597 LLMLICADILVVVILLVELAWK----------------RFFTRH-LTFH 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	46/218 (21%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	92/433 (21%)
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	27/131 (21%)