Protein Alignment GRIK1 and Ir68b

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_648548.1
• Gene: Ir68b / 39378
• FlyBaseID: FBgn0036250
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 107/633 - (16%)
• Similarity: 199/633 - (31%)
• Gaps: 181/633 - (28%)

Human   261 DLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMY 325
            |..||:|:|||     ..|.||         .:|.: :||..:..|...|..|
  Fly    50 DYSALELDLYR-----CVGSRL---------PVITR-NMEAHELEPFRRTDSL------------ 87

Human   326 DAVYMVAIASHRAS-------QLTVSSLQCHRHK---PWRLGPRFMNL-IKEARWDG--LTGHIT 377
             :::.:..|....|       .|.....:.|.||   .|....|...| :....|..  |.|...
  Fly    88 -SIFQIPAAEKGDSLVRRILDMLNPHQRRKHMHKYLFVWPNAGRHQLLRLFRGSWAKKLLYGLAI 151

Human   378 FNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITD 442
            ..:.||   .||.|..:                          |.....:...|.....:..:.|
  Fly   152 TGRENG---TFDFDPFA--------------------------WGGLQVIQRLDGEVPYARKVKD 187

Human   443 SLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNI-LGFIYDVKLVPDG--KY 504
             |....|.. ::..:|.:...:|.....|....:|....::.|:.|. :.:::     |:.  .|
  Fly   188 -LRGYPLRF-SMFTDPLMAMPRSPVETAGYQAVDGVAARVVGEMLNASVTYVF-----PEDNESY 245

Human   505 GAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS 569
            |.....|.:.|:|.:::......|.....:.......::...|:....:.::. ..:...|....
  Fly   246 GRCLPNGNYTGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVV-PASAIQPEYLI 309

Human   570 FLNPLSPDIWMYVLLACLGVSCVLFVIARFT-----------PYEWYNPHPCNPDSDVVENNFTL 623
            |:......:|..:|:..|.|..|.:|:.|..           ...||         :::|
  Fly   310 FVRVFRRTVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWY---------EILE----- 360

Human   624 LNSFWFGVGALMQQGSELMP-KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSAD 687
                .||...:.:....|.. .::.|.::|  |..|:.::.:.|.|.|.:.......|..:|..|
  Fly   361 ----MFGKTHVGEPAGRLSSFSSMRTFLMG--WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVD 419

Human   688 DL------------------AKQTKIEYGAV---------------------------------- 700
            ||                  :..|:.:||.:
  Fly   420 DLVHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIMRDF 484

Human   701 --RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQR 763
              ||...:|:..:::...|.....::.|...|.::......:.| |.:.|:..:|....|:..|.
  Fly   485 HARDFLAITYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHR-LESLYSGFLEHGFFEHWRQM 548

Human   764 NCNLTQIGGLIDSK------GYGVGTPIGS---PYRDK---ITIAILQ 799
            :. :|::|...|::      |....|..||   ..|:|   :|:.|||
  Fly   549 DL-ITRVGASPDAEEFLEDLGDQTDTDSGSNELAIRNKKVVLTLDILQ 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	34/182 (19%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	70/435 (16%)
Ir68b	NP_648548.1	None