Protein Alignment GRIK1 and Ir64a

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_647962.1
• Gene: Ir64a / 38616
• FlyBaseID: FBgn0035604
• Length: 859
• Species: Drosophila melanogaster
• Alignment Length: 759
• Identity: 137/759 - (18%)
• Similarity: 249/759 - (32%)
• Gaps: 215/759 - (28%)

Human   305 PPRPETGLLDGMMTTEAALMYDAVYMVAIASHRA-SQLTVSSLQCHRHKPWRLGPRFMN------ 362
            |.||..|...|...|.:....::.::..:....| .|:.|..|.|     ..:..||:.
  Fly   118 PNRPGNGPTGGFSQTPSQAQSNSEWLEGVLRMEALRQIAVVDLAC-----GAVSRRFLELASAKM 177

Human   363 ---------LIKEARWDGLT-----------GHITFNKTNG--LRKDFDLDIISLKE-------- 397
                     ||::..|.|.|           |.:...:..|  ::...|.|:.|::.
  Fly   178 LYSEKFHWLLIEDFAWHGRTQTAEGSGKRDDGEMEEEEPPGQQIQATDDEDLPSIESFLGGMNLY 242

Human   398 EGTE----KAAGEVSKH-LYKVWK------------KIGIWNSNSGLNM-----TDSNKDKSSNI 440
            ..||    |...|.:.: |:.||.            :||.:....|:.:     |.|...:..::
  Fly   243 MNTELTLAKRMSEAAHYTLFDVWNPGLNYGGHVNLTEIGSFTPTEGIQLHTWFRTTSTVRRRMDM 307

Human   441 TDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYG 505
            ..:.....::||.......:||..:.......|....:..:||..:.::..:.:.:.......|
  Fly   308 QHARVRCMVVVTNKNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFVLSRTTSWGY- 371

Human   506 AQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSF 570
            .:|  |.::||:..||.:..|:..||:.....|.|.||.:....:.....::|.|..|......|
  Fly   372 VKN--GRFDGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRPCFIFRHPRSTQKDRIVF 434

Human   571 LNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEW-YNPH-------------------------- 608
            |.|.:.|:|  :|:...||..| |::...|..|| ..||
  Fly   435 LQPFTNDVW--ILIVGCGVLTV-FILWFLTTIEWKLVPHDGSALIKPKGGAPPRHHYQQQQQQEQ 496

Human   609 ---PCNP---------------------DSDVVE------------NNF---------------- 621
               |..|                     ||..::            |.:
  Fly   497 VEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLNKYIKDRKAKQKKAPERVG 561

Human   622 TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSA 686
            ..|.|..|.||.:.|||.......:|.|.:......|:..|...|:|::...|.:|:.:: |.:.
  Fly   562 LFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSASIVGTLLMEKPKT-IKTL 625

Human   687 DDLAKQTKIEYGA------------VRDGSTMTFFKK--SKISTYEKMWA--------------- 722
            .||. .:.::.|.            .:|..:|..:.|  :.:.|.::..|
  Fly   626 SDLV-HSSLKVGMEDILYNRDYFLHTKDPVSMELYAKKITSVPTTKENEADEDEPVDPNPVSTDP 689

Human   723 ------FMSSRQ----------------QTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNC 765
                  .:.|.:                :|.|:|:........:...|.::.|:.|    .|..|
  Fly   690 AKSYRDIVHSHETGAHAKDNAASNWLDPETGLLRHLGFAFHVDVAAAYKIIAETFS----EQDIC 750

Human   766 NLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKL--HMMKEKWWRGNGCPEEDNKEAS 828
            :||::......|...: ....||.|..|:..:.::.|.|.|  |.   ..|.....|.....|.|
  Fly   751 DLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGILTYHF---NVWHSRKPPCVKKIETS 811

Human   829 ALGV--ENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQK 870
            .|.|  :.:....::|.....:::.:...|.:| |:.:|.|:.|
  Fly   812 DLHVDMDTVSSALLILLFSYAITLMILGTEILY-SKWHNRIQLK 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	33/184 (18%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	89/500 (18%)
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:473866	28/119 (24%)
		Lig_chan	563..828	CDD:459656	51/274 (19%)