Protein Alignment GRIK1 and clumsy

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Alignment Length: 969
• Identity: 338/969 - (34%)
• Similarity: 540/969 - (55%)
• Gaps: 109/969 - (11%)

Human    21 LLYFLCYILPQTAP---QVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQ 82
            |.:||...||..|.   ....:|.||.:.::|    .|:||:   |:::|...|..|..|...:.
  Fly     6 LTHFLLIALPVLADIDRSQFMVGSIFTSDKDE----SEIAFR---TAVDRANILERNVELVPIVV 63

Human    83 RINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW-KHPSVDNKD-- 144
            ..|..|||...:..|:.::.||.|:||||..||...:.|||:.|::|||...| .:.|:.:::
  Fly    64 YANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHS 128

Human   145 LFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGN 209
            ...:|::||...:|:.:.::|..:.|::.|||||....|.:||::::.....:....::||..|:
  Fly   129 TMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGD 193

Human   210 KDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDL-ELYRYS 273
             |.:|.|||:|...:..:|..|:.:...:||:|...:.|:.||...|...||..::|. ||   |
  Fly   194 -DHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGEL---S 254

Human   274 GV--NMTGFRLLNIDNPHVSSIIEKWSMERLQAPPR-----PETGLLDGMMTTEAALMYDAVYMV 331
            ||  |:|..||::..:.||.:::..|. ||.:...|     |      ..:.::..|:.|||::.
  Fly   255 GVEANITTVRLMDPSDFHVKNVVHDWE-EREKREGRYFKVDP------NRVKSQMILLNDAVWLF 312

Human   332 AIASHRA---SQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDII 393
            :......   .:||...|:|.|.|||..|.|.:..||....:..||.|.||: ||.|..|.|..:
  Fly   313 SKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFM 376

Human   394 SLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEP 458
            .|..:|               :..:..|:..:||::.:.:::....:...|:|:|.||::.|..|
  Fly   377 ELNSDG---------------FLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAP 426

Human   459 YVMYRKSDKP--LYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGE-WNGMVKEL 520
            ::..|:..:.  |.||.|:|||.:||:.|::.:|.|.::.::.|||||||.|...: |:|:|::|
  Fly   427 FLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQL 491

Human   521 IDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLA 585
            ||..|||.:..||:|..|.:.:||:.||||||||||:.||......:||||:|.|.|:|:|:..|
  Fly   492 IDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSA 556

Human   586 CLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRI 650
            .|.:|.:||.:||..|.:|.|||||. :.:.|||.::::|:.|..:|:||.||.:::|||.|||:
  Fly   557 YLFISLLLFALARMAPDDWENPHPCK-EPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRL 620

Human   651 VGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIS 715
            |.|:||||.|::::|||||||||||..|..:.|:||:|||.|:||:|||:..||||.||:.|..|
  Fly   621 VTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFS 685

Human   716 TYEKMWAFMSSRQQTALVRNSDEGIQRVLTTD--YALLMESTSIEYVTQRNCNLTQIGGLIDSKG 778
            ||:|||..|.|...:...:.:|||::||....  ||.|||||::||..:|.|:|.||||.:|.|.
  Fly   686 TYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKS 750

Human   779 YGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR----GNGC--PEEDNKEASALGVENIGG 837
            ||:..|..||||.:|:.|:|:|.|.|:|..:|.|||:    |..|  .:||..:...||:||:||
  Fly   751 YGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGG 815

Human   838 IFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRIRFYFRNKVRF---------------- 886
            :|:||..||:.::.:...||:: :.|:..||:|   ..::..|:::..|
  Fly   816 VFLVLGLGLLSAMVLGCTEFLW-NVKSVAIEEK---ISLKEAFKSEALFAARIWITTKPVHTSSE 876

Human   887 ---------------HGRKKQSLGVEKC---------LSFNAIMEELG--ISLKNQKKI 919
                           |..|.|.|.::..         .|.::.::::|  .|||:||.:
  Fly   877 SGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTV 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	117/406 (29%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	179/373 (48%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	117/403 (29%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	179/373 (48%)