Protein Alignment GRIK1 and Ir25a

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 984
• Identity: 260/984 - (26%)
• Similarity: 420/984 - (42%)
• Gaps: 237/984 - (24%)

Human    12 LWTRDTSWALLYFL----CYILPQTAPQVLRIGGIF-ETVENEPVNVEELAFKFAVTSINRNRTL 71
            ||       ||.||    .:.|...|.....|..:| ..|:|||.   ..|.:..:|.:.:|
  Fly    12 LW-------LLGFLSLLSSFSLEIAAQTTQNINVLFINEVDNEPA---AKAVEVVLTYLKKN--- 63

Human    72 MPNTTLTYDIQRINLFDSFEASR--------RACDQLALGVAALFGP-----SHSSSVSA--VQS 121
                 :.|.:. :.| ||.||::        ..|::.|..:.....|     :..|.:::  |:|
  Fly    64 -----IRYGLS-VQL-DSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETVKS 121

Human   122 ICNALEVPHIQT---------RWKHPSVDN-KDLFYINLYPDYAAISRAILDLVLYYNWKTVTVV 176
            ...||.:|.|..         :|:  .:|. |..:.:.:.|....|..||..:|::.|.....::
  Fly   122 FTQALGLPTISASYGQQGDLRQWR--DLDEAKQKYLLQVMPPADIIPEAIRSIVIHMNITNAAIL 184

Human   177 YEDSTGL----------IRLQELIKAPSRYNIK------IKIRQLPSGN-------KDAKPLLKE 218
            |:||..:          |:.:.:|.|.::...:      .|:|.|...|       :..:.:|:.
  Fly   185 YDDSFVMDHKYKSLLQNIQTRHVITAIAKDGKREREEQIEKLRNLDINNFFILGTLQSIRMVLES 249

Human   219 MKKGK-EFYVIFDCSHETAAEILKQ-----ILFMGMMTEYYHY------FFTTLDL--------- 262
            :|... |....:....:...||..|     |:||..|. |..|      ..||.:|
  Fly   250 VKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMA-YTQYRDRLGLLRTTYNLNEEPQLSSA 313

Human   263 FALDLELYRY--------SGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGL-LDGMMT 318
            |..||.|..:        ||........||.|:              .|....|:..| |....|
  Fly   314 FYFDLALRSFLTIKEMLQSGAWPKDMEYLNCDD--------------FQGGNTPQRNLDLRDYFT 364

Human   319 --TEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKT 381
              ||.            .|:....|...|.|     |:                  .|| :|.|
  Fly   365 KITEP------------TSYGTFDLVTQSTQ-----PF------------------NGH-SFMK- 392

Human   382 NGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLAN 446
                  |::||..|:..|......          |.||.|.|.....:...::::..|:|   |:
  Fly   393 ------FEMDINVLQIRGGSSVNS----------KSIGKWISGLNSELIVKDEEQMKNLT---AD 438

Human   447 RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKG 511
            ....:.|:::.|::| |....|    ..::|||:||:.|::.|:.|.|.::.|.|||:|..::.|
  Fly   439 TVYRIFTVVQAPFIM-RDETAP----KGYKGYCIDLINEIAAIVHFDYTIQEVEDGKFGNMDENG 498

Human   512 EWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL-GISILYRKPNGTNPGVFSFLNPLS 575
            :|||:||:|:|.:||:.:..:::...||.||||:.|:..| ||:|:.::|:..: .:|.||..|.
  Fly   499 QWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-SLFKFLTVLE 562

Human   576 PDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSE 640
            .::|:.:|.|....|.::::..|::||.:.|......| |..:..|.|....||.:.:|..||..
  Fly   563 TNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKD-DEEKREFNLKECLWFCMTSLTPQGGG 626

Human   641 LMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGST 705
            ..||.||.|:|...||.|..|||:||||||||||||.|:::|::|.||||||.||.|..:...|.
  Fly   627 EAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLAKQYKILYAPLNGSSA 691

Human   706 MTFF--------------------------KKSKIST--------YEKMWAFMSSRQQTALVRNS 736
            ||:|                          ::||::.        |.|||..|   |:..|....
  Fly   692 MTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAM---QEAKLPATL 753

Human   737 DEGIQRV----LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAI 797
            ||.:.||    ..|.:|.|.::|.|.|:...||:|..:|.....|.|.:....||..:|:...||
  Fly   754 DEAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSHLKDQFNNAI 818

Human   798 LQLQEEGKLHMMKEKWWRGNGC------PEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGE 856
            |.|..:.:|..:|||||:.:..      ||:   ::..:.::||||:|||:..|:.::....:.|
  Fly   819 LTLLNKRQLEKLKEKWWKNDEALAKCDKPED---QSDGISIQNIGGVFIVIFVGIGMACITLVFE 880

Human   857 F-IYKSRKN 864
            : .|:.|||
  Fly   881 YWWYRYRKN 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	94/473 (20%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	139/407 (34%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	37..418	CDD:380606	92/463 (20%)
		PBP2_iGluR_putative	438..836	CDD:270435	139/407 (34%)