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Protein Alignment GRIK1 and GluRIIC

DIOPT Version :9

Sequence 1:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	930	Identity:	275/930 - (29%)
Similarity:	461/930 - (49%)	Gaps:	121/930 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    12 LWTR----DTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLM 72
            :|.|    ...|: .:|:|    ::..|.:.||..|...|.|    .|..|...|.:||...:
  Fly     1 MWQRILLLGCMWS-AFFMC----RSRGQQINIGAFFYDDELE----LEKEFMTVVNAINGPES-- 54

Human    73 PNTTLTYD-IQRINLFD-SFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW 135
            ..|...|. |:|:...| |......|||.:..||||:||||..::...|..:||:..:|||:...
  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDI 119

Human   136 KHPSVD----NKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVY--EDSTGLIRLQELIKAPS 194
            ....:.    |..: .:||||..|.:|:|..|:|..:.|:..|:||  :|:....|||:|::...
  Fly   120 SDEGIQAEKPNHQM-TLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLRE 183

Human   195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTT 259
            .:|..:::|:... :.|.:.:.|.::  .|..|:.||......|:|......|:..:|.|.|.|.
  Fly   184 VHNDVVRVRKFHK-DDDFRVMWKSIR--GERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTN 245

Human   260 LDLF-------ALDLELYRYSGVNMTGFRLL-NIDNPHVS----------SIIEKWSMERLQAPP 306
            |:.:       |.|.|.:   .||:|..||| |.|.|..|          :|:.:.|     .||
  Fly   246 LETYTDHLEELAADNETF---AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESS-----DPP 302

Human   307 RPETGLLDGMMTTEAALMYDAVYMVAIASHRAS-----QLTVSSLQC----HRHKPWRLGPRFMN 362
            |          |....|::||:.:.|.:...||     ::.|..:.|    ...:.|.:|.....
  Fly   303 R----------TLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLAR 357

Human   363 LIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIG--IWNSNS 425
            |:|     |.:|   .|.||     |...|:...|:| ::....:  .:|.....||  ||:...
  Fly   358 LMK-----GTSG---VNNTN-----FRTSILQFDEDG-QRITFNI--EVYDPLDGIGIAIWDPRG 406

Human   426 GLNMTDSNKDKSSNITDSLANRTLI--VTTILEEPYVMYRKSDKP--LYGNDRFEGYCLDLLKEL 486
              .:|..|       .|..|.:.:|  |.|.:..||..|.::.:.  |.||..::||.:||:..:
  Fly   407 --QITQLN-------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAI 462

Human   487 SNILGFIYDVKLVPDGKYG-AQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMT 550
            :..:||.|....|.|.:|| ...:..:|||::.|:|::.|.:.:..||||..|:..:||:.|||.
  Fly   463 ARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQ 527

Human   551 LGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS 614
            ||:||| |:.|: ....:.::|.|...::|:::|::...::.:..::||.:..:|.||||||.|.
  Fly   528 LGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDP 591

Human   615 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERM 679
            :|:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:|||||||||||..:|
  Fly   592 EVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKM 656

Human   680 ESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVL 744
            |..|.:..||:.|.|:::|.:..|||......|..:.|...:..|::...:|..:::.||:.||.
  Fly   657 EGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVR 721

Human   745 TT--DYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 807
            ..  ||..|||:|::||..::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|:|:
  Fly   722 KNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELY 786

Human   808 MMKEKWWR--GNGCPEEDNKEASA-LGVENIGGIFIVLAAGLVLSVFVAIGEF-IYKSRKNNDIE 868
            .:|:|||:  ...|.||.:.:|:. :..|.:.|||..|.||::::..:.|.|| :|       ::
  Fly   787 DLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY-------VQ 844

Human   869 QKGKSSRIRF--YFRNKVRF 886
            |.....|:.|  .|:.::||
  Fly   845 QVALEERLTFKDAFKKEIRF 864

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.