DRSC/TRiP Functional Genomics Resources

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Protein Alignment GRIK1 and Ir8a

DIOPT Version :9

Sequence 1:NP_001317923.1 Gene:GRIK1 / 2897 HGNCID:4579 Length:949 Species:Homo sapiens
Sequence 2:NP_727328.1 Gene:Ir8a / 31867 FlyBaseID:FBgn0052704 Length:936 Species:Drosophila melanogaster


Alignment Length:809 Identity:212/809 - (26%)
Similarity:346/809 - (42%) Gaps:152/809 - (18%)


- Green bases have known domain annotations that are detailed below.


Human   160 AILDLVLYYNWKT-VTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGN--------KDAKPL 215
            |::||. |.:|:. ..:|.....|.:||:.::: |........:||..:.|        :||...
  Fly    84 AVIDLT-YSHWEEGYNLVRSLGIGYVRLERIMR-PFLDMFGDFMRQKRANNVAMVFMNARDAVEA 146

Human   216 LKEMKKGKEF-YVIFDCSH-ETAAEILKQILFMGMMTEYYHYF------------FTTLDLFALD 266
            :::|..|..| .:|.|.|. :.....|::|..:.....|...|            ....|||...
  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRP 211

Human   267 LE-------------LYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMT 318
            ||             .||......|.|.|    ||...          .::.|.|:.....| .|
  Fly   212 LEWHFVFLDTRDRVFKYRRQAELCTRFTL----NPRAI----------CRSMPMPDLYCGSG-FT 261

Human   319 TEAALMYDAV------------YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDG 371
            .:.|::.:.:            |.:||  ::....|.||.:.  ..|  |.....|.:....|..
  Fly   262 MQRAMLLNVLRSLINAAQVSPGYPLAI--YQDCNATASSSEV--SDP--LEKDDYNWLDMVHWSN 320

Human   372 LTG------HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMT 430
            ...      ||        :..|...:..|.......|....|:|..|.  .:..|:|...:.:.
  Fly   321 FLAYAPPLPHI--------QDQFQSPVPGLTFAVNISAGYYSSEHEAKT--DLAAWSSVGEMRLL 375

Human   431 DSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD------KPLYGNDRFEGYCLDLLKELSNI 489
                    |.|.|.|.|...:.|....|:...|:.:      :...|...:||||:|.:..||..
  Fly   376 --------NETISPARRFFRIGTAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQK 432

Human   490 LGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFM-TLGI 553
            |.|.:::.....|..|..|:.|||:|:|.:|:....|.|:|.|.:...||:||||..|:. ..||
  Fly   433 LNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGI 497

Human   554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYN-----PHPCNPD 613
            ||..||| .....:|.|:..|..::|:.::.|.:|.:.:::.:.:::||...|     |:.|   
  Fly   498 SIAIRKP-VRRTSLFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC--- 558

Human   614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 678
                 ..|||..||||.:.:...||....|||:|.|::...:|.|.:::::::||||||||||||
  Fly   559 -----REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVER 618

Human   679 MESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIS--TYEKMW---AFMSSR----------- 727
            |::|:.|.:.||:|::|.|..|:|..|..:|...|.:  |..:||   |..:|:           
  Fly   619 MQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYP 683

Human   728 ------------QQTALVRNSDEGIQRV---LTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSK 777
                        ..:..|.::.||...|   ...|||.:.:|..|:|...||||||::|.:...:
  Fly   684 IKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVFAEQ 748

Human   778 GYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN---GCPEEDNKEASALGVENIGGIF 839
            .|.|....||...|:::.|||:||::.....:|.|:|..:   .||..:::|...|  |::||:|
  Fly   749 PYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGITL--ESLGGVF 811

Human   840 IVLAAGLVLSVFVAIGEFIYKSRKNNDIE 868
            |....||||::.....|.:|..:|.|.:|
  Fly   812 IATLFGLVLAMMTLGMEVLYYKKKQNALE 840

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GRIK1NP_001317923.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:324556 62/323 (19%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:328725 127/411 (31%)
Glutamate binding. /evidence=ECO:0000250 531..533 0/1 (0%)