Protein Alignment GRIK1 and GluRIIE

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Alignment Length: 960
• Identity: 333/960 - (34%)
• Similarity: 496/960 - (51%)
• Gaps: 130/960 - (13%)

Human    19 WALLYFLCYILPQTAPQVLRIGGI--FETVENEPV------NVEE--LAFKFAVTSINRNRTLMP 73
            |:|  |..:|....| |....||.  ::::|:.|:      |.|:  :.|..|:...|:.    .
  Fly    10 WSL--FSIHISVNWA-QYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----V 67

Human    74 NTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHP 138
            .|:||...:.:|..|::::..:.|..|..|:|.:||||...:...:.|||:|:::|||.:...
  Fly    68 GTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS-- 130

Human   139 SVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQEL---------IKAPS 194
              :|.:.|  ||:|..|.:::|:..|:..:||.....:||.:..|..|.||         :....
  Fly   131 --ENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVL 191

Human   195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTT 259
            ||::::        |.:.|.:|:.::|..:..::...|.||..|.|.|...:|::.|.|.|....
  Fly   192 RYDMQL--------NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGN 248

Human   260 LDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGM--MTTEAA 322
            ||..:.|||.|:||..|:||.||.:.:...|..::.|...      |..:....:|.  :|.|.|
  Fly   249 LDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVEMA 307

Human   323 LMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRL------------GPRFMNLIKEARWDG--LT 373
            |.||||           ||...:|:....||...            |..|.|.::..|...  ||
  Fly   308 LTYDAV-----------QLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLT 361

Human   374 GHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSN-----SGLNMTDSN 433
            |.|.|.  ..:||.:.||:|.|:..|.               .|:|.|:.:     ..|..|.:.
  Fly   362 GPIYFE--GNVRKGYHLDVIELQPSGI---------------VKVGTWDEDRQYRPQRLAPTTAQ 409

Human   434 KDKSSNITDSLANRT-LIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVK 497
            .|   ::.:||||:| :|:.::..:||....::.|.|.||.::|||.:||:|||::.|||  :..
  Fly   410 FD---SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGF--NFT 469

Human   498 LVPDGK-YGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKP 560
            .|..|. ||:.| ...|..||::|::..|||||:..||||..||:.:||:.|||.|||:|||.||
  Fly   470 FVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKP 534

Human   561 NGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLN 625
            ....|.:|:|::|.|.::|.::..:.||||...|::.|.:|.||.||:||..:.:.:||.|||.|
  Fly   535 QKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGN 599

Human   626 SFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA 690
            |.||..|||:|||||:.|||||||.|...|||||||::||||||||||||:|:.:|.|:|.||||
  Fly   600 SIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLA 664

Human   691 -KQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLT-TDYALLME 753
             .:..:.|||.:.|||..||..|....|:||..|||...| .|..::.||:.||.| |.||.|||
  Fly   665 DNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLME 728

Human   754 STSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR--G 816
            ||||||.|:|.|||.:||..:|.||||:......|:|.|...|:|:|||:|.|..||.|||.  |
  Fly   729 STSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVG 793

Human   817 NG--CPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRIRFY 879
            .|  ..:||..:|:.|.:.|:.|:|.||..|...::...|..::....|        |:...|..
  Fly   794 TGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMK--------KAHHYRVP 850

Human   880 FRNKVRFHGRKKQSLGVEKCLSFNAIMEELGISLKNQKKIKKKSRTKGKS 929
            .|:.::..        .:..:.||..:.    .|||...|..:||....|
  Fly   851 LRDALKEE--------FQFVIDFNNYVR----VLKNSASIYSRSRQSSMS 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	111/432 (26%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	184/373 (49%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	107/413 (26%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	184/373 (49%)
		Lig_chan	551..824	CDD:459656	138/273 (51%)