Protein Alignment GRIK1 and Ir41a

DIOPT Version :10

• Sequence 1: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Sequence 2: NP_995744.4
• Gene: Ir41a / 2768714
• FlyBaseID: FBgn0040849
• Length: 648
• Species: Drosophila melanogaster
• Alignment Length: 602
• Identity: 107/602 - (17%)
• Similarity: 201/602 - (33%)
• Gaps: 156/602 - (25%)

Human   359 RFMNLIKEAR----WDGLTGHITF----NKTNGLRKDFDLD---IISLKEEGTEKAAGEVSKHLY 412
            ||:|...:|.    |..|.....|    |::...|..|..|   |:.:..:.:..::.::
  Fly   106 RFVNAFNKASVYSIWRSLHNKFVFAHIANESPESRNHFFEDQPNILFVVRDHSSASSFDI----- 165

Human   413 KVWKKIGIWNSN-SGLNMTDS----------NKDKSSNITDSLANRTLIVTTILEEPYVMYRKS- 465
            |..|.:|....| |.:.:.|.          .|...::..::|..|.:|:......||.:.:.:
  Fly   166 KTNKFVGRKAENPSQMILVDRYLASEQRFQFGKSLFADKLNNLQGREVIIAGFDYPPYTVIKHNM 230

Human   466 -----DKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGE------WNGMVKE 519
                 |..:.|...|:...:| ..|...:|.|.............|.||.|:      .:|.:..
  Fly   231 STNAQDMGVSGESDFKNVYID-GTETRIVLNFCEQFNCTIQIDSSAANDWGKVYPNMSGDGALGM 294

Human   520 LIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSP---DIWMY 581
            ||:.:||:.:..:...|.....:|.|...:..||:.|...|    ..:.|:..||.|   .:|..
  Fly   295 LINRKADICIGAMYSWYEDYTYLDLSMYLVRSGITCLVPAP----LRLTSWYLPLEPFKETLWAA 355

Human   582 VLLACLGVSC-----------VLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALM 635
            :|| ||....           .|:|:..:....|    .|        .:|.:..:|    ...:
  Fly   356 ILL-CLCAEATGLVLAYKSEQALYVLPGYREGWW----TC--------TSFGVCTTF----KLFI 403

Human   636 QQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAV 700
            .|.......:|:.|::....:...|||.|.|...||:.||:..|:...|:.      |::.:
  Fly   404 SQSGNSKAYSLTVRVLLFACFLNDLIITSIYGGGLASILTIPSMDEAADTV------TRLRF--- 459

Human   701 RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNC 765
                            :...|| .:|....:.:|.|||.:.:.:..::.:..:...:.....::
  Fly   460 ----------------HRLQWA-ANSEAWVSAIRASDEALVKDILYNFHIYSDDELLRLAQDQH- 506

Human   766 NLTQIGGLIDSKGYG---VGTPIGS--------------------------PYRDKITIAILQLQ 801
              .:||..::...:|   :|..:|.                          |..||:...|....
  Fly   507 --MRIGFTVERLPFGHFAIGNYLGPQAIDQLVIMKDDIYFQYTVAFVPRLWPLLDKLNTLIYSWH 569

Human   802 EEGKLHMMKEKWWRGNGCPEEDNKEAS----------------ALGVENIGGIFIVLAAGLVLSV 850
            ..|     .:|:|......:..|.:..                .||:.|..|..||...|..::.
  Fly   570 SSG-----FDKYWEYRVVADNLNLKIQQQVQETMTGTKDIGPVPLGMSNFAGFIIVWILGSAIAT 629

Human   851 FVAIGE--FIYKSRKNN 865
            ...:.|  ..|..:::|
  Fly   630 LTFLLELSLTYILKQSN 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	17/83 (20%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	75/423 (18%)
Ir41a	NP_995744.4	None