DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lap3 and S-Lap4

DIOPT Version :9

Sequence 1:	NP_001011910.1	Gene:	Lap3 / 289668	RGDID:	1307985	Length:	519	Species:	Rattus norvegicus
Sequence 2:	NP_729613.1	Gene:	S-Lap4 / 326188	FlyBaseID:	FBgn0052064	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	219/518 - (42%)
Similarity:	309/518 - (59%)	Gaps:	24/518 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 VALRRLGVRGLWDRGLSTA-----DMTKGLVLGIYSKDKDDDVPQFTSAGENFNKLVSGRLREML 71
            |..|||.|..|..  :.||     ..:||||:|:|.|:.|:| |:.|.|||..|..:.|:|:||:
  Fly    11 VVQRRLPVSHLIQ--IRTACGGESKSSKGLVVGVYQKENDND-PKLTPAGEKVNDRLHGKLQEMI 72

  Rat    72 ---NISGPPLKAGKTRTFYGLHQDFPSVVVVGLGKRSAGVDDQENWHEGKENIRAAVAAGCRQVQ 133
               .|:|   ..|:.:.|..:..:|.|:.|||:|....|.::.|...||.||:|.|...|.|.:|
  Fly    73 CQSKITG---HLGRGKIFNNIDPEFRSMAVVGVGLEGIGFNELEMLDEGMENVRVAAGIGARSLQ 134

  Rat   134 DLELPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKVAVSAK--LHGSGDLEAWEKGVLFASGQ 196
            ::.:..|.||....|:.|||||||.::.|.|:..|:|.....|  |:.|.|.|.|.:||..|..|
  Fly   135 EIGVSEVFVDGMDYAEQAAEGAVLAVWRYCDMNSKRKPPHIPKLELYESPDYEGWTRGVFKAEAQ 199

  Rat   197 NLARQLMESPANEMTPTRFAEVIEKNLKSASSKTEVHIRTKSWIEEQEMGSFLSVAKGSEEPPVF 261
            ||||::.::||..||||.||:.....|  ......|.|||..|||:|.:.|||.:||||.||||.
  Fly   200 NLARRMCDTPACCMTPTLFAQATVDAL--CPCGITVEIRTMEWIEQQRLHSFLMIAKGSCEPPVL 262

  Rat   262 LEIHYTGSPNATEAPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPI 326
            :||.|.|: |..:.|::|:||||||:||.::::....|:..||.|.|||:..:.:...|.|.|||
  Fly   263 MEITYCGT-NPEDKPILFLGKGITFNSGAMNLRKCRGMEEYRACMSGAASCVAMMRCVAALALPI 326

  Rat   327 NIIGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAH-TFNPKVIINAA 390
            |:..:.|||||||||.|.||||||...|.|::.|.|.|..|.:::||.|.|.. |:.|:::::.|
  Fly   327 NVCCIIPLCENMPSGMACKPGDVVTLMNHKSMAVRNLDKAGVVVMADPLLYGQSTYKPRLVVDVA 391

  Rat   391 TLTGAMDVALGSGATGVFTNSSWLWNKLFEASVETGDRVWRMPLFEHYTRQVIDCQLADVNNLGK 455
            ||...:..|.|.||||:|:||.::|.:...|...|||||||:||:.:|.:|:.|....|::|.|:
  Fly   392 TLGSGVKKAFGGGATGIFSNSHYIWKQFQSAGALTGDRVWRLPLWNYYRKQITDEMGYDLSNDGR 456

  Rat   456 YRSAGACTAAAFLREFVTHTKWAHLDI--AGVMTNKDEIPYL-RKGMSGRPTRTLIEFLLRFS 515
             ..|.:|.|||.|.|.|....|||||.  .|::|....:||| .|.|:|||||||.:||.:.:
  Fly   457 -GLANSCLAAAVLHELVPCVDWAHLDTRGTGLLTKYGLVPYLTAKYMTGRPTRTLAQFLYQMA 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lap3	NP_001011910.1	Peptidase_M17	33..511	CDD:238247	209/486 (43%)
S-Lap4	NP_729613.1	PRK00913	31..514	CDD:234863	209/490 (43%)
S-Lap4	NP_729613.1	Peptidase_M17	35..514	CDD:238247	209/486 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354148
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	O	PTHR11963
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X713
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710