DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment REM1 and Rgk1

DIOPT Version :9

Sequence 1:	XP_005260461.1	Gene:	REM1 / 28954	HGNCID:	15922	Length:	306	Species:	Homo sapiens
Sequence 2:	NP_725875.3	Gene:	Rgk1 / 14462605	FlyBaseID:	FBgn0264753	Length:	1379	Species:	Drosophila melanogaster

Alignment Length:	392	Identity:	114/392 - (29%)
Similarity:	165/392 - (42%)	Gaps:	113/392 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     7 QEAKTPLHRRASTP----LPLSPRGHQPGRLSTVPST--QSQHPRL-------------GQS--- 49
            |..|.|..|.:..|    ||     .|..|::::|:|  :.::.||             |.|
  Fly  1009 QSVKMPGSRASGRPNQLCLP-----QQRSRVASMPNTGVEEEYYRLRHFSITGKGVVNRGDSLKS 1068

Human    50 ---------ASLNP-----PTQKPSPAPDD-------WSSESSDSEGSWEALYRVVLLGDPGVGK 93
                     ||.|.     .||:...||..       .||..|.:.......|||::||.|.|||
  Fly  1069 RRSRSNNSVASSNSSTEHLTTQQQLSAPASVSARTSLASSRESSTSNPGNGPYRVLMLGGPAVGK 1133

Human    94 TSLASLFAGKQ-----ERDLHEQLGDPALPSVAEDVYERTLTVDGEDTTLVVVDTWEAEKLDKSW 153
            :||.|.|...:     :..:.::.|:.|:          ::.:.||::.|:.:|....|     .
  Fly  1134 SSLVSQFMTSEYLHAYDTSIDDESGEKAV----------SVLLSGEESELIFIDHGYTE-----M 1183

Human   154 SQESCLQG--GSAYVIVYSIADRGSFESASELRIQLRRTHQ-ADHVPIILVGNKADLARCREVSV 215
            :.:.||..  ...|.::||.|||.|| |.:|..:|:..|:| .....:|||.|||||||.|.|:.
  Fly  1184 TPDECLTNYDPHGYCVIYSAADRSSF-SVAEQVLQVLWTNQNIAQKAVILVSNKADLARSRLVTS 1247

Human   216 EEGRACAVVFDCKFIETSATLQHNVAELFEGVVRQLRLR-----------RRDSAAKE------- 262
            |||:|.|..:||||||||..:.|||.||..|::.|:||:           |:.|..|.
  Fly  1248 EEGKAMATAYDCKFIETSVGINHNVDELLVGLLSQIRLKLENPEKSRDLFRKRSIRKSKRRACSP 1312

Human   263 ----------PPAP------RRPASLAQRARRFLARLTARSARRRALKAR-------SKSCHNLA 304
                      |..|      ..|.|.....|::....|:.|.:.:.|..|       ||||.||.
  Fly  1313 LNAGCLNANTPLGPLGEAVATPPGSAQSSPRKYRGSRTSTSLKVKGLLGRVWTRDSKSKSCENLH 1377

Human   305 VL 306
            ||
  Fly  1378 VL 1379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REM1	XP_005260461.1	RGK	81..306	CDD:206715	87/273 (32%)
REM1	XP_005260461.1	small_GTPase	81..245	CDD:197466	65/171 (38%)
Rgk1	NP_725875.3	DUF2967	459..715	CDD:288079
		P-loop_NTPase	1121..1379	CDD:304359	87/273 (32%)
		small_GTPase	1121..1286	CDD:197466	68/180 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D301527at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45775
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5084
SonicParanoid	1	1.000	-	-		X743
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.050