Protein Alignment TRIB2 and KCC4

DIOPT Version :10

• Sequence 1: NP_067675.1
• Gene: TRIB2 / 28951
• HGNCID: 30809
• Length: 343
• Species: Homo sapiens
• Sequence 2: NP_009907.2
• Gene: KCC4 / 850334
• SGDID: S000000529
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 302
• Identity: 88/302 - (29%)
• Similarity: 137/302 - (45%)
• Gaps: 34/302 - (11%)

Human    50 ETPNLSHCVSCIGKYLLLEPL---EGDHVFRAVHLHSGEELVCKVFDISCY--------QESLAP 103
            ||.:.:...|.||.:.|.|.|   ....|..|.|..:|.....||...|.:        .:|:.|
Yeast     7 ETHSAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLP 71

Human   104 --------CFCLSAHSNINQITEIILGETKAYVFFE-RSYGDMHSFVRTCKKLREEEAARLFYQI 159
                    ...|.:|.|:..:.::.......|:..| ...|::.:.:.....|.|.||...|.||
Yeast    72 YNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQI 136

Human   160 ASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEIL 224
            ...:::||..|:|.||||....:.  :....:|:.....| .|:.|.|.|....|.|.|.:|||:
Yeast   137 IIGISYCHALGIVHRDLKPENLLL--DSFYNIKIADFGMA-ALQTDADLLETSCGSPHYAAPEIV 198

Human   225 NTSG-SYSGKAADVWSLGVMLYTMLVGRYPFHDIEPS--SLFSKIRRGQFNIPE--TLSPKAKCL 284
              || .|.|.|:||||.||:|:.:|.||.||.:...:  .|..|:::|||.:|.  .:|..|:.|
Yeast   199 --SGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDL 261

Human   285 IRSILRREPSERLTSQEILDHPWFSTDFSVSNSAYGAKEVSD 326
            |..||..:|.:|:..::||.||......::.:|    |.:.|
Yeast   262 IGKILVVDPRQRIKIRDILSHPLLKKYQTIKDS----KSIKD 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIB2	NP_067675.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..50		88/302 (29%)
		PK_TRB2	67..308	CDD:270924	79/265 (30%)
KCC4	NP_009907.2	Protein Kinases, catalytic domain	19..285	CDD:473864	81/270 (30%)
		Kcc4p_like_C	920..1034	CDD:213379